SNP Report

Basic Info

Name	rs3752826 dbSNP Ensembl
Location	chrCHR_HSCHR17_2_CTG2:1264549 - 1264549(1)
Variant Alleles	A/C
Ancestral Allele	C
Minor Allele	A
Minor Allele Frequence	0.27496
Functional Annotation	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant.
Consequence to Transcript	downstream_gene_variant(ENST00000489287); intron_variant(ENST00000264335, ENST00000466227, ENST00000571732, ENST00000573026, ENST00000573196, ENST00000575977); NMD_transcript_variant(ENST00000466227, ENST00000573196); non_coding_transcript_exon_variant(ENST00000469398, ENST00000486241); non_coding_transcript_variant(ENST00000469398, ENST00000486241); upstream_gene_variant(ENST00000496706, ENST00000627099, ENST00000616643, ENST00000626999, ENST00000627231, ENST00000628106, ENST00000629090, ENST00000630606, ENST00000629090, ENST00000630606, ENST00000630045, ENST00000630699, ENST00000630045, ENST00000630699, ENST00000628059)
No. of Studies	1 (Positive: 0; Negative: 1; Trend: 0)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	YES

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Liu, J,2011(b)	A/G		For BD: allele, OR[95%CI]=1.09[0.97-1.23], P-value = 0.1651,...... For BD: allele, OR[95%CI]=1.09[0.97-1.23], P-value = 0.1651, P-permutation=0.8933; genotype, P-value = 0.3858, P-permutation=0.998 More...	No significant association was observed. No significant association was observed.	Negative

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon	17p13.3	1(0/1/0)

SNPs in LD with rs3752826 (count: 11) View in gBrowse (chrCHR_HSCHR17_2_CTG2:1249262..1296957 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Functional Annotation	r²[population]
rs7207904	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant	0.867[JPT]
rs9895157	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant	0.954[CHB]; 1.0[JPT]
rs2131432	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant	0.954[CHB]; 0.976[CHD]; 0.867[JPT]
rs9748126	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	0.954[CHB]; 0.909[JPT]
rs7213824	intron_variant; NMD_transcript_variant	0.953[CHB]; 0.976[CHD]; 0.906[JPT]
rs7212894	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant	1.0[CHB]; 1.0[JPT]
rs11655176	downstream_gene_variant; intron_variant; NMD_transcript_variant	1.0[CHB]; 1.0[CHD]; 1.0[JPT]
rs8067801	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	0.953[CHB]; 0.86[JPT]
rs7219635	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant	1.0[CHB]; 1.0[CHD]; 1.0[JPT]
rs9912147	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	0.954[CHB]; 0.867[JPT]
rs7212572	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant	1.0[CHB]; 1.0[JPT]

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Liu, J,2011(b)	For SZ:allele, OR[95%CI]=0.95[0.84-1.071], P-value = 0.38553, P-permutation=0.997;genotype, P-value = 0.04423, P-permutation=0.4343	Significant association was found, but the significance was lost after permutation.	Positive

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Liu, J,2011(b)	For MDD:allele, OR[95%CI]=1.1[0.97-1.24], P-value = 0.1254, P-permutation=0.7886;genotype, P-value = 0.29907, P-permutation=0.9841	No significant association was observed.	Negative