SNP Report

Basic Info

Name	rs3757930 dbSNP Ensembl
Location	chr8:32731600 - 32731600(1)
Variant Alleles	C/T
Ancestral Allele	T
Minor Allele	T
Minor Allele Frequence	0.375399
Functional Annotation	downstream_gene_variant; intron_variant; non_coding_transcript_variant.
Consequence to Transcript	downstream_gene_variant(ENST00000631040); intron_variant(ENST00000287842, ENST00000356819, ENST00000405005, ENST00000518084, ENST00000518104, ENST00000518206, ENST00000519240, ENST00000519301, ENST00000520407, ENST00000520502, ENST00000521670, ENST00000522402, ENST00000522569, ENST00000523041, ENST00000523079, ENST00000523534, ENST00000539990); non_coding_transcript_variant(ENST00000522569)
No. of Studies	2 (Positive: 0; Negative: 2; Trend: 0)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	NO

SNP related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Thomson, P. A., 2007			Individual P-value = 0.16 for BP, Individual P-value = 0.116...... Individual P-value = 0.16 for BP, Individual P-value = 0.1164 for SCZ and BP More...	It is nominally (P<0.05) significant in the single SNP analy...... It is nominally (P<0.05) significant in the single SNP analysis by FBAT and HBAT, More...	Negative
Walker, R. M.,2010			X² test: P-value = 0.16 for Scottish 1, P-value =...... X² test: P-value = 0.16 for Scottish 1, P-value = 0.57 for Scottish 2, P-value = 0.35 for German, P-value = 0.17 for merged Scottish, P-value = 0.7 for merged all More...	No significant association was observed in BD. No significant association was observed in BD.	Negative

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
NRG1	neuregulin 1	8p12	15(10/5/0)

SNPs in LD with rs3757930 (count: 1) View in gBrowse (chr8:32731600..32744874 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Literature-origin SNPs with LD	Functional Annotation	r²[population]
rs7007436		downstream_gene_variant; intron_variant; non_coding_transcript_variant; upstream_gene_variant	0.892[CEU]; 0.854[TSI]

Overlap with SZ from cross-disorder studies (count: 2)

Reference	Statistical Result	Description	Result Category
Walker, R. M.,2010	X² test:P-value = 0.2 for Scottish 1, P-value = 0.69 for Scottish 2, P-value = 0.16 for German, P-value = 0.17 for merged Scottish, P-value = 0.85 for merged all	No significant association was observed.	Negative
Thomson, P. A., 2007	Individual P-value = 0.2035 for SCZ , Individual P-value = 0.1164 for SCZ and BP		Negative

Overlap with MDD from cross-disorder studies (count: 0)