BDgene

SNP Report

Basic Info
Name rs3918342 dbSNP Ensembl
Location chr13:105533400 - 105533400(1)
Variant Alleles C/T
Ancestral Allele T
Minor Allele T
Minor Allele Frequence 0.466054
No. of Studies 11 (Positive: 4; Negative: 7; Trend: 0)
Source Literature
Overlap with SZ? YES
Overlap with MDD? YES

SNP related studies (count: 11)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Gawlik, M.,2010 C/T Armitage's trend test: P-value = 0.2 Armitage's trend test: P-value = 0.2 No significant association was observed in BD. No significant association was observed in BD. Negative
Detera-Wadleigh, S. D., 2006 C/T Fisher P-value = 0.0000 for all, P-value = 0.0309 for BP Onl...... Fisher P-value = 0.0000 for all, P-value = 0.0309 for BP Only More... When results are combined across studies and phenotypes, thi...... When results are combined across studies and phenotypes, this marker showed significant combined p value. Only three studies have been published in bipolar-disorder samples, but significant (p<0.05) combined results are seen for three markers spanning more than 74 kb. More... Positive
Schulze, T. G.,2005 T/C C For German group : All Patients With Bipolar Affective Disor...... For German group : All Patients With Bipolar Affective Disorder, P-value < 0.05 , OR=1.33, 95CI=1.06-1.68.Patients With a History of Psychotic Symptoms, P-value < 0.01 , OR=1.46, 95CI=1.12-1.91. Patients With No History of Psychotic Symptoms, P-value > 0.05 , OR=1.03, 95CI=0.73-1.46. For Polish group: All Patients With Bipolar Affective Disorder, P-value > 0.05 , OR=1.09, 95CI=0.86-1.39.Patients With a History of Psychotic Symptoms, P-value > 0.05 , OR=1.09, 95CI=0.79-1.49. Patients With No History of Psychotic Symptoms, P-value > 0.05 , OR=1.48, 95CI=0.96-2.28 More... Significant associations were found in German group. Significant associations were found in German group. Positive
Tan, J., 2014 T/C T vs. C: OR = 0.97, 95% CI = 0.87–1.08, P-value = 0.535 T vs. C: OR = 0.97, 95% CI = 0.87–1.08, P-value = 0.535 We did not obtain a significant association between M23 and ...... We did not obtain a significant association between M23 and BD. More... Negative
Bass, N. J.,2009 C/T chi-squared tests: for BP, allele, X2(1 d.f.)=4.2...... chi-squared tests: for BP, allele, X2(1 d.f.)=4.293, P-value = 0.038; for BP+SCZ, allele, X2(1 d.f.)=7.044, P-value = 0.008 More... Significant association was observed in allelic association ...... Significant association was observed in allelic association in BP and BP+SCZ samples. More... Positive
Gaysina, D.,2010 C/T chi-squared tests: allele P-value = 0.52 for UK sample; alle...... chi-squared tests: allele P-value = 0.52 for UK sample; allele P-value = 0.89 for Canadian sample. More... No significant association was observed in BD. No significant association was observed in BD. Negative
Zhang, Z.,2009(a) A/G Allelic association: Odds ratio (95% CI)=0.92(0.78-1.10), P-...... Allelic association: Odds ratio (95% CI)=0.92(0.78-1.10), P-value = 0.367 More... No significant association was observed No significant association was observed Negative
Maheshwari, M.,2009 C/T TDT: Raw TDT P-value = 0.942, Adaptive permutation corrected...... TDT: Raw TDT P-value = 0.942, Adaptive permutation corrected P-value = 0.258 More... No significant allelic association with BP was found No significant allelic association with BP was found Negative
Grigoroiu-Serbanescu, M.,2010 T/C Allelic association analysis: for non-psychotic patients, P-...... Allelic association analysis: for non-psychotic patients, P-value = 0.116, OR(95%CI)=1.57(0.87-2.84); for psychotic patients, P-value = 0.847, OR(95%CI)=0.97(0.71-1.32) More... No significant association was observed in BD. No significant association was observed in BD. Negative
Seifuddin, F.,2012 T/C Meta-analysis OR=1.14, 95% CI=1.01-1.30 , P-value = 0.050 Meta-analysis OR=1.14, 95% CI=1.01-1.30 , P-value = 0.050 No significance was found after correction for multiple test...... No significance was found after correction for multiple testing. More... Negative
Zuliani, R.,2009 C/T Gray matter density in the left temporal lobe pole: voxel le...... Gray matter density in the left temporal lobe pole: voxel level, T = 7.04, pFWE = 0.002, peak MNI coordinates = (-40, 11, -28); Gray matter density in the right amygdala at two peak voxels [peak 1: T = 3.45, pFWE = 0.031, peak MNI coordinates = (26, -7, -17); peak 2: T = 3.41, pFWE = 0.034, peakMNI coordinates = (25, -8, -16)] Post-hoc analyses : genotype-by-group interaction in the temporal lobe for M23 (F = 3.98, p = 0.021). More... Genetic variation at both the M23 loci in G72 were associate...... Genetic variation at both the M23 loci in G72 were associated with decreased gray matter density within the left temporal pole in people with bipolar disorder.M23 was also associated with reductions in right amygdala gray matter density.The genetic imaging associations were found only in patients with bipolar disorder. More... Positive

SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
DAOA D-amino acid oxidase activator 13q33.2 21(13/7/1)

SNPs in LD with rs3918342 (count: 27) View in gBrowse (chr13:105510133..105545526 )
The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 27)


Overlap with SZ from cross-disorder studies (count: 3)
Reference Statistical Result Description Result Category
Detera-Wadleigh, S. D., 2006 Fisher P-value = 0 for all, P-value = 0.0006 for SCZ Only When results are combined across studies and phenotypes, this marker showed significant combined p value. Combined results in schizophrenia are significant for several markers and are highly significant (p<0.001) for three markers spanning more than 82 kb. Positive
Bass, N. J.,2009 chi-squared tests:for SCZ, allele, X2(1 d.f.)=5.824, P-value = 0.016 Significant association was observed in allelic association in SCZ. Positive
Tan, J., 2014 T vs. C: OR= 0.99, 95% CI= 0.92–1.08, P-value= 0.893; TT+TC vs. CC: OR= 0.97, 95% CI= 0.87–1.08, P-value = 0.633; TT vs. TC+CC: OR= 1.03, 95% CI= 0.91–1.17, P-value = 0.6; TT vs. TC: OR = 1.03, 95%CI = 0.93–1.15, P-value = 0.532; TC vs. CC: OR = 0.96, 95%CI = 0.89–1.02, P-value = 0.202; TT vs. CC: OR= 1.01, 95% CI= 0.86–1.19, P-value = 0.893. The pooled ORs failed to indicate that M23 was significantly associated with SCZ in six models. Negative

Overlap with MDD from cross-disorder studies (count: 2)
Reference Statistical Result Description Result Category
Tan, J., 2014 T vs. C: OR = 0.93; 95% CI = 0.83–1.03; P-value = 0.179 Significant association between M23 and DD was not found. Negative
Gawlik, M.,2010 Armitage's trend test:P-value = 0.29 No significant association was observed. Negative