SNP Report

Basic Info

Name	rs2282586 dbSNP Ensembl
Location	chr11:120987701 - 120987701(1)
Variant Alleles	G/A
Ancestral Allele	G
Minor Allele	A
Minor Allele Frequence	0.324081
Functional Annotation	3_prime_UTR_variant; downstream_gene_variant.
Consequence to Transcript	3_prime_UTR_variant(ENST00000527524); downstream_gene_variant(ENST00000438375)
No. of Studies	2 (Positive: 1; Negative: 1; Trend: 0)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	NO

SNP related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Pickard, B. S., 2006	A/G		P-value = 0.02 between BPD cases and controls; P-value = 0....... P-value = 0.02 between BPD cases and controls; P-value = 0.058 between all cases and controls More...	it was associated with bipolar disorder it was associated with bipolar disorder	Positive
Yosifova, A.,2009	A/G		Allelic association: P-value = 0.27 Allelic association: P-value = 0.27	No significant association was observed No significant association was observed	Negative

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
GRIK4	glutamate receptor, ionotropic, kainate 4	11q23.3	2(1/1/0)

SNPs in LD with rs2282586 (count: 5) View in gBrowse (chr11:120978353..120991380 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Functional Annotation	r²[population]
rs2298723	intron_variant	0.919[CEU]; 0.823[TSI]
rs4323878	intron_variant	0.88[CEU]
rs1008966	intron_variant	0.96[CEU]; 0.929[TSI]
rs2155094	intron_variant	0.96[CEU]
rs4935758	downstream_gene_variant	0.96[CEU]; 0.851[TSI]

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Pickard, B. S., 2006	P-value = 0.358 between SCZ cases and controls; P-value = 0.058 between all cases and controls		Negative

Overlap with MDD from cross-disorder studies (count: 0)