BDgene

SNP Report

Basic Info
Name rs3135730 dbSNP Ensembl
Location chr10:121566280 - 121566280(1)
Variant Alleles T/C
Ancestral Allele T
Minor Allele C
Minor Allele Frequence 0.175319
Functional Annotation intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant.
Consequence to Transcript intron_variant(ENST00000336553, ENST00000346997, ENST00000351936, ENST00000356226, ENST00000357555, ENST00000358487, ENST00000359354, ENST00000360144, ENST00000369056, ENST00000369058, ENST00000369059, ENST00000369060, ENST00000369061, ENST00000457416, ENST00000490349, ENST00000604236, ENST00000611527, ENST00000613048, ENST00000613324, ENST00000636922); NMD_transcript_variant(ENST00000604236); non_coding_transcript_variant(ENST00000490349); upstream_gene_variant(ENST00000491475)
No. of Studies 1 (Positive: 0; Negative: 1; Trend: 0)
Source Literature
Overlap with SZ? YES
Overlap with MDD? YES

SNP related studies (count: 1)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Wang, T.,2012 A/G Allelic association results: P-value = 0.142, Permutated P-v...... Allelic association results: P-value = 0.142, Permutated P-value = 0.784 More... No significant association was observed in BD. No significant association was observed in BD. Negative

SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
FGFR2 fibroblast growth factor receptor 2 10q25.3-q26 2(1/1/0)

SNPs in LD with rs3135730 (count: 12) View in gBrowse (chr10:121548220..121566280 )
The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 12)


Overlap with SZ from cross-disorder studies (count: 1)
Reference Statistical Result Description Result Category
Wang, T.,2012 Allelic association results:P-value = 0.765, Permutated P-value = 1 No significant association was observed in SZ. Negative

Overlap with MDD from cross-disorder studies (count: 1)
Reference Statistical Result Description Result Category
Wang, T.,2012 Allelic association results:P-value = 0.214, Permutated P-value = 0.909 No significant association was observed in MDD Negative