Meta-analysis Report

Reference	Shi, J., 2008 (a) PMID: 18023149
Citation	Shi, J., J. A. Badner, et al. (2008). "Allelic association of G72/G30 with schizophrenia and bipolar disorder: a comprehensive meta-analysis." Schizophr Res 98(1-3): 89-97.
Disease Type	Bipolar Disorder & Schizophrenia
Study Type	Candidate-gene association study

Samples	The present meta-analysis combined 18 association articles published before April of 2007. There were 19 independent studies of SCZ, with 4304 cases, 5423 controls, and 1384 families, and four independent studies of BP with 1145 cases, 1829 controls, and 174 families.
Statistic Method	Cochran's chi-square-based Q-statistic test was applied to assess between-study heterogeneity. Overall ORs and their 95% CIs were estimated under both the Mantel-Haenszel's fixed-effects. Significance of overall OR was examined using a Z-test, and the P-values were adjusted using Bonferroni correction when there were multiple tests. Evidence for publication bias was assessed using Egger's regression asymmetry statistics with a funnel plot of natural logarithm of OR (Ln(OR)) against inverse SE in each study. The meta-analyses were carried out using the program Meta-analysis with Interactive eXplanations (MIX, version 1.54)
Basic Result	Of 15 single nucleotide polymorphisms (SNPs) analyzed in the 95-kb G72/G30 gene region, M18/rs947267 and M22/rs778293 showed association with SCZ in Asians, and M24/rs1421292 with SCZ in Europeans. The associations of C allele at M18 and A allele at M22 with SCZ in Asians survived conservative Bonferroni correction for multiple testing for 15 markers and subgroup analysis (adjusted P=0.0000253 for M18; adjusted P=0.009 for M22). No single maker showed evidence of overall association with BP.