SNP Report

Basic Info

Name	rs946903 dbSNP Ensembl
Location	chr1:147625465 - 147625465(1)
Variant Alleles	T/C
Ancestral Allele	T
Minor Allele	C
Minor Allele Frequence	0.304313
Functional Annotation	3_prime_UTR_variant; downstream_gene_variant.
Consequence to Transcript	3_prime_UTR_variant(ENST00000234739); downstream_gene_variant(ENST00000609196)
No. of Studies	1 (Positive: 0; Negative: 1; Trend: 0)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	YES

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Li, J.,2011(b)	C/T		Third-Stage Sample: for BPD, allele association P-value = 0....... Third-Stage Sample: for BPD, allele association P-value = 0.52, OR(95%CI)=0.96(0.83-1.10) More...	No significant association was observed. No significant association was observed.	Negative

SNP related genes (count: 2)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
ACP6	acid phosphatase 6, lysophosphatidic	1q21	1(1/0/0)
BCL9	B-cell CLL/lymphoma 9	1q21	1(1/0/0)

SNPs in LD with rs946903 (count: 6) View in gBrowse (chr1:147610227..147633200 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Functional Annotation	r²[population]
rs12409268	intron_variant	0.951[JPT]
rs6675828	downstream_gene_variant; intron_variant; non_coding_transcript_variant	0.808[CHB]; 0.803[CHD]; 0.907[JPT]
rs7512513	downstream_gene_variant; intron_variant; non_coding_transcript_variant	0.878[CHB]; 0.812[CHD]; 0.907[JPT]
rs12132534	downstream_gene_variant	0.877[CHB]; 0.905[JPT]
rs12122799	intron_variant; non_coding_transcript_variant; upstream_gene_variant	0.803[CHD]; 0.907[JPT]
rs17160476	intron_variant	0.873[CHB]; 0.907[JPT]

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Li, J.,2011(b)	Third-Stage Sample:for SZ, allele association P-value = 0.47, OR(95%CI)=0.95(0.83-1.10);Combined Third-Stage Sample, allele association P-value = 0.16, OR(98%CI)=0.95(0.89-1.02)	No significant association was observed.	Negative

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Li, J.,2011(b)	Third-Stage Sample:for MDD, allele association P-value = 0.006, OR(95%CI)=0.82(0.71-0.95)	Significant association was observed in MDD.	Positive