BDgene

SNP Report

Basic Info
Name rs2241514 dbSNP Ensembl
Location chr11:125456130 - 125456130(1)
Variant Alleles C/T
Ancestral Allele C
Minor Allele T
Minor Allele Frequence 0.338658
Functional Annotation downstream_gene_variant; intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant.
Consequence to Transcript downstream_gene_variant(ENST00000534022); intron_variant(ENST00000278919, ENST00000392709, ENST00000527350, ENST00000533294, ENST00000577924); non_coding_transcript_exon_variant(ENST00000524427); non_coding_transcript_variant(ENST00000392709, ENST00000524427, ENST00000527350, ENST00000533294); upstream_gene_variant(ENST00000526507, ENST00000528863, ENST00000530096, ENST00000532778)
No. of Studies 2 (Positive: 0; Negative: 2; Trend: 0)
Source Literature
Overlap with SZ? YES
Overlap with MDD? NO

SNP related studies (count: 2)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Hodgkinson, C. A., 2007 C/T Allelic P-value = 0.369, genotypic P-value = 0.654 in Cauc...... Allelic P-value = 0.369, genotypic P-value = 0.654 in Caucasians. More... No association to bipolar disorder was found for any of the ...... No association to bipolar disorder was found for any of the nine markers typed in these populations at the allelic or the genotypic level. More... Negative
Yamada, K.,2004 G/A Association analysis: Fisher's exact test, allele P-value = ...... Association analysis: Fisher's exact test, allele P-value = 0.697, genotype P-value = 0.642 More... No significant association was observed in BD. No significant association was observed in BD. Negative

SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
FEZ1 fasciculation and elongation protein zeta 1 (zygin I) 11q24.2 2(0/2/0)

SNPs in LD with rs2241514 (count: 18) View in gBrowse (chr11:125414990..125472998 )
The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 18)


Overlap with SZ from cross-disorder studies (count: 2)
Reference Statistical Result Description Result Category
Hodgkinson, C. A., 2007 Allelic P-value = 0.510, genotypic P-value = 0.788 in Caucasians. Allelic P-value = 0.911, genotypic P-value = 0.964 in African Americans. No association to schizophrenia was found for any of the nine markers typed in these populations at the allelic or the genotypic level. Negative
Yamada, K.,2004 Association analysis:Fisher's exact test, allele P-value = 0.77, genotype P-value = 0.853 No significant association was observed in SZ. Negative

Overlap with MDD from cross-disorder studies (count: 0)

Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback Acknowledgements
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Last update: March 31, 2016