BDgene

SNP Report

Basic Info
Name rs4279178 dbSNP Ensembl
Location chr4:47066563 - 47066563(1)
Variant Alleles G/A
Ancestral Allele A
Minor Allele A
Minor Allele Frequence 0.485823
Functional Annotation intron_variant; NMD_transcript_variant.
Consequence to Transcript intron_variant(ENST00000295454, ENST00000510909, ENST00000513567); NMD_transcript_variant(ENST00000510909)
No. of Studies 2 (Positive: 1; Negative: 0; Trend: 1)
Source Literature
Overlap with SZ? YES
Overlap with MDD? YES

SNP related studies (count: 2)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Hamshere, M. L.,2009 lambda-corrected Cochran-Armitage trend test: P-value = 2.49...... lambda-corrected Cochran-Armitage trend test: P-value = 2.49E-06 More... one of independently associated SNPs that exceed a significa...... one of independently associated SNPs that exceed a significance threshold of P-value E-05(all of which have good quality clusterplots) More... Trend
Huang, J.,2010 A/G Omnibus GWAS Test: P-value = 0.0000000393, best-fit model is...... Omnibus GWAS Test: P-value = 0.0000000393, best-fit model is Bipolar II specific More... Significant association was found in BD-II. Significant association was found in BD-II. Positive

SNP related genes (count: 2)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 4p12 3(2/0/1)
ADM adrenomedullin 11p15.4 1(1/0/0)

SNPs in LD with rs4279178 (count: 3) View in gBrowse (chr4:47066563..47083300 )
The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 3)


Overlap with SZ from cross-disorder studies (count: 1)
Reference Statistical Result Description Result Category
Huang, J.,2010 Omnibus GWAS Test:P-value > 5E-05 No significant association was observed. Negative

Overlap with MDD from cross-disorder studies (count: 1)
Reference Statistical Result Description Result Category
Huang, J.,2010 Omnibus GWAS Test:P-value > 5E-05 No significant association was observed. Negative