Study Report

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Basic Info

Reference	Zeng, Z.,2011 PMID: 20733578
Citation	Zeng, Z., T. Wang, et al. (2011). "Common SNPs and haplotypes in DGKH are associated with bipolar disorder and schizophrenia in the Chinese Han population." Mol Psychiatry 16(5): 473-475.
Disease Type	Bipolar Disorder & Schizophrenia & Major Depressive Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	1139 unrelated BPD patients (645 type I BPD), 1122 unrelated SCZ patients, 1122 unrelated major depressive disorder patients and 1138 shared healthy controls
SNP/Region/Marker Size	13 SNPs
Predominant Ethnicity	Mongloid
Population	Chinese

Detail Info

Sample Diagnosis	DSM
Technique	genotyping
Statistical Method	Main association analyses were performed on Haploview 4.1.
Result Summary	After permutation, one SNP rs2122246 located in the 30-flank region of DGKH showed significant association in the type I BPD subgroup (OR = 0.799, 95% confidence interval (CI) = 0.693-0.921), and another SNP rs1170099 in the 30-flank region was strongly associated with SCZ (OR = 1.612, 95% CI = 1.231-2.112).In haplotypic association,Block1 were associated with both BPD and BPDI,moreover,Block1 and block3 were associated with SCZ. Results for major depressive disorder were totally negative. There was no nominally significant allelic or haplotypic association in any of the analyses.In summary, our results support DGKH as shared risk factor of BPD and SCZ in the Chinese Han population.

Genetic factors reported by this study for BD

SNPs reported by this study for BD (count: 13)

SNP	Related Gene(s)	Risk Allele	Statistical Values	Author Comments	Result Category
rs1012053	DGKH	A	Allelic association: P-value = 0.191, permutated P-value = 0.829 for BPD; P-value = 0.15, permutated P-value = 0.739 for BPDI	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs1170098	DGKH	C	Allelic association: P-value = 0.716, permutated P-value = 1 for BPD; P-value = 0.358, permutated P-value = 0.976 for BPDI	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs1170099	DGKH	A	Allelic association: P-value = 0.062, permutated P-value = 0.428 for BPD; P-value = 0.099, permutated P-value = 0.586 for BPDI	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs1170191	DGKH	C	Allelic association: P-value = 0.179, permutated P-value = 0.81 for BPD; P-value = 0.292, permutated P-value = 0.944 for BPDI	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs9315885	DGKH MAPK6PS3	T	Allelic association: P-value = 0.453, permutated P-value = 0.995 for BPD; P-value = 0.256, permutated P-value = 0.915 for BPDI	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs716934	DGKH	A	Allelic association: P-value = 0.069, permutated P-value = 0.462 for BPD; P-value = 0.022, permutated P-value = 0.188 for BPDI	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs347387	DGKH	C	Allelic association: P-value = 0.015, permutated P-value = 0.132 for BPD; P-value = 0.007, permutated P-value = 0.065 for BPDI	Significant association was found in BPD. Significant association was found in BPD.	Positive
rs2122246	DGKH	G	Allelic association: P-value = 0.056, permutated P-value = 0.399 for BPD; P-value = 0.002, permutated P-value = 0.0186 for BPDI	Significant association was found in BPDI. Significant association was found in BPDI.	Positive
rs9566931	DGKH	G	Allelic association: P-value = 0.523, permutated P-value = 0.999 for BPD; P-value = 0.262, permutated P-value = 0.922 for BPDI	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs9533042	DGKH	G	Allelic association: P-value = 0.94, permutated P-value = 1 for BPD; P-value = 0.635, permutated P-value = 1 for BPDI	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs9532988	DGKH MAPK6PS3	G	Allelic association: P-value = 0.12, permutated P-value = 0.656 for BPD; P-value = 0.196, permutated P-value = 0.831 for BPDI	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs9315897	DGKH	C	Allelic association: P-value = 0.089, permutated P-value = 0.547 for BPD; P-value = 0.122, permutated P-value = 0.669 for BPDI	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs9566940	DGKH	C	Allelic association: P-value = 0.466, permutated P-value = 0.996 for BPD; P-value = 0.533, permutated P-value = 0.999 for BPDI	No significant association was observed in BD. No significant association was observed in BD.	Negative

Haplotypes reported by this study for BD (count: 12)

Markers	Haplotype	Related Gene(s)/Region(s)	Statistical Values	Author Comments	Result Category
rs9315885 - rs9532988 - rs1012053	T-G-A	DGKH	Haplotypic association:P-value = 0.316, permutated P-value = 0.968 for BPD; P-value = 0.45, permutated P-value = 0.996 for BPDI	No significant association was found . No significant association was found .	Negative
rs9315885 - rs9532988 - rs1012053	C-A-C	DGKH	Haplotypic association:P-value = 0.003, permutated P-value = 0.018 for BPD; P-value = 0.002, permutated P-value = 0.015 for BPDI	Significant association was found in both BPD and BPDI. Significant association was found in both BPD and BPDI.	Positive
rs9315885 - rs9532988 - rs1012053	T-A-A	DGKH	Haplotypic association:P-value = 0.233, permutated P-value = 0.911 for BPD; P-value = 0.571, permutated P-value = 1 for BPDI	No significant association was found . No significant association was found .	Negative
rs716934 - rs9566931 - rs9315897 - rs2122246	T-G-T-G	DGKH	Haplotypic association:P-value = 0.989, permutated P-value = 1 for BPD; P-value = 0.392, permutated P-value = 0.992 for BPDI	No significant association was found . No significant association was found .	Negative
rs9315885 - rs9532988 - rs1012053	C-A-A	DGKH	Haplotypic association:P-value = 0.00000387, permutated P-value = 0 for BPD; P-value = 0.0000259, permutated P-value = 0.0001 for BPDI	Significant association was found in both BPD and BPDI. Significant association was found in both BPD and BPDI.	Positive
rs716934 - rs9566931 - rs9315897 - rs2122246	T-A-T-A	DGKH	Haplotypic association:P-value = 0.058, permutated P-value = 0.367 for BPD; P-value = 0.005, permutated P-value = 0.036 for BPDI	Significant association was found in BPDI. Significant association was found in BPDI.	Positive
rs716934 - rs9566931 - rs9315897 - rs2122246	T-A-T-G	DGKH	Haplotypic association:P-value = 0.735, permutated P-value = 1 for BPD; P-value = 0.58, permutated P-value = 1 for BPDI	No significant association was found . No significant association was found .	Negative
rs716934 - rs9566931 - rs9315897 - rs2122246	A-A-T-G	DGKH	Haplotypic association:P-value = 0.37, permutated P-value = 0.994 for BPD; P-value = 0.089, permutated P-value = 0.554 for BPDI	No significant association was found . No significant association was found .	Negative
rs716934 - rs9566931 - rs9315897 - rs2122246	A-A-C-G	DGKH	Haplotypic association:P-value = 0.227, permutated P-value = 0.904 for BPD; P-value = 0.321, permutated P-value = 0.973 for BPDI	No significant association was found . No significant association was found .	Negative
rs1170099 - rs9566940	G-T	DGKH	Haplotypic association:P-value = 0.04, permutated P-value = 0.262 for BPD; P-value = 0.082, permutated P-value = 0.522 for BPDI	No significant association was found . No significant association was found .	Negative
rs1170099 - rs9566940	A-T	DGKH	Haplotypic association:P-value = 0.519, permutated P-value = 1 for BPD; P-value = 0.547, permutated P-value = 1 for BPDI	No significant association was found . No significant association was found .	Negative
rs1170099 - rs9566940	A-C	DGKH	Haplotypic association:P-value = 0.5, permutated P-value = 0.999 for BPD; P-value = 0.548, permutated P-value = 1 for BPDI	No significant association was found . No significant association was found .	Negative

Genes reported by this study for BD (count: 1)

Gene	Statistical Values/Author Comments	Result Category
DGKH	In summary, our results support DGKH as shared risk factor of BPD and SCZ in the Chinese Han populat...... In summary, our results support DGKH as shared risk factor of BPD and SCZ in the Chinese Han population. More...	Positive

Genetic factors reported by this study for SZ and/or MDD

SNPs reported by this study for SZ/MDD

Disease	SNP	Related Gene(s)	Statistical Values	Description	Result Category
SZ	rs1170098	DGKH	Allelic association:P-value = 0.628, permutated P-value = 1 for SCZ	No significant association was observed after permutation.	Negative
SZ	rs1012053	DGKH	Allelic association:P-value = 0.074, permutated P-value = 0.494 for SCZ	No significant association was observed after permutation.	Negative
SZ	rs9566940	DGKH	Allelic association:P-value = 0.281, permutated P-value = 0.941 for SCZ	No significant association was observed after permutation.	Negative
SZ	rs9566931	DGKH	Allelic association:P-value = 0.874, permutated P-value = 1 for SCZ	No significant association was observed after permutation.	Negative
SZ	rs9533042	DGKH	Allelic association:P-value = 0.009, permutated P-value = 0.086 for SCZ	No significant association was observed after permutation.	Negative
SZ	rs347387	DGKH	Allelic association:P-value = 0.404, permutated P-value = 0.989 for SCZ	No significant association was observed after permutation.	Negative
SZ	rs2122246	DGKH	Allelic association:P-value = 0.069, permutated P-value = 0.472 for SCZ	No significant association was observed after permutation.	Negative
SZ	rs1170191	DGKH	Allelic association:P-value = 0.052, permutated P-value = 0.385 for SCZ	No significant association was observed after permutation.	Negative
SZ	rs1170099	DGKH	Allelic association:P-value = 0.0005, permutated P-value = 0.005 for SCZ	Significant association was found.	Positive
SZ	rs9532988	DGKH MAPK6PS3	Allelic association:P-value = 0.282, permutated P-value = 0.942 for SCZ	No significant association was observed after permutation.	Negative
SZ	rs9315897	DGKH	Allelic association:P-value = 0.583, permutated P-value = 1 for SCZ	No significant association was observed after permutation.	Negative
SZ	rs9315885	DGKH MAPK6PS3	Allelic association:P-value = 0.014, permutated P-value = 0.127 for SCZ	No significant association was observed after permutation.	Negative
SZ	rs716934	DGKH	Allelic association:P-value = 0.658, permutated P-value = 1 for SCZ	No significant association was observed after permutation.	Negative
MDD	rs1170098	DGKH	Allelic association:P-value > 0.05 for MDD.	No significant association was observed after permutation.	Negative
MDD	rs1012053	DGKH	Allelic association:P-value > 0.05 for MDD.	No significant association was observed after permutation.	Negative
MDD	rs9566940	DGKH	Allelic association:P-value > 0.05 for MDD.	No significant association was observed after permutation.	Negative
MDD	rs9566931	DGKH	Allelic association:P-value > 0.05 for MDD.	No significant association was observed after permutation.	Negative
MDD	rs9533042	DGKH	Allelic association:P-value > 0.05 for MDD.	No significant association was observed after permutation.	Negative
MDD	rs347387	DGKH	Allelic association:P-value > 0.05 for MDD.	No significant association was observed after permutation.	Negative
MDD	rs2122246	DGKH	Allelic association:P-value > 0.05 for MDD.	No significant association was observed after permutation.	Negative
MDD	rs1170191	DGKH	Allelic association:P-value > 0.05 for MDD.	No significant association was observed after permutation.	Negative
MDD	rs1170099	DGKH	Allelic association:P-value > 0.05 for MDD.	No significant association was observed after permutation.	Negative
MDD	rs9532988	DGKH MAPK6PS3	Allelic association:P-value > 0.05 for MDD.	No significant association was observed after permutation.	Negative
MDD	rs9315897	DGKH	Allelic association:P-value > 0.05 for MDD.	No significant association was observed after permutation.	Negative
MDD	rs9315885	DGKH MAPK6PS3	Allelic association:P-value > 0.05 for MDD.	No significant association was observed after permutation.	Negative
MDD	rs716934	DGKH	Allelic association:P-value > 0.05 for MDD.	No significant association was observed after permutation.	Negative

Haplotypes reported by this study for SZ/MDD

Disease	Markers	Haplotype	Related Gene(s)/Region(s)	Statistical Values	Description	Result Category
SZ	rs9315885 - rs9532988 - rs1012053	C-A-C	DGKH	Haplotypic association:P-value = 0.116, permutated P-value = 0.719 for SCZ	No significant association was observed in SZ.	Negative
SZ	rs9315885 - rs9532988 - rs1012053	C-A-A	DGKH	Haplotypic association:P-value = 0.018, permutated P-value = 0.147 for SCZ	No significant association was observed in SZ.	Negative
SZ	rs9315885 - rs9532988 - rs1012053	T-G-A	DGKH	Haplotypic association:P-value = 0.446, permutated P-value = 0.998 for SCZ	No significant association was observed in SZ.	Negative
SZ	rs9315885 - rs9532988 - rs1012053	T-A-A	DGKH	Haplotypic association:P-value = 0.0005, permutated P-value = 0.005 for SCZ	Significant association was observed in SZ.	Positive
SZ	rs716934 - rs9566931 - rs9315897 - rs2122246	A-A-T-G	DGKH	Haplotypic association:P-value = 0.623, permutated P-value = 1 for SCZ	No significant association was observed in SZ.	Negative
SZ	rs716934 - rs9566931 - rs9315897 - rs2122246	T-A-T-A	DGKH	Haplotypic association:P-value = 0.243, permutated P-value = 0.945 for SCZ	No significant association was observed in SZ.	Negative
SZ	rs716934 - rs9566931 - rs9315897 - rs2122246	T-A-T-G	DGKH	Haplotypic association:P-value = 0.219, permutated P-value = 0.924 for SCZ	No significant association was observed in SZ.	Negative
SZ	rs716934 - rs9566931 - rs9315897 - rs2122246	T-G-T-G	DGKH	Haplotypic association:P-value = 0.297, permutated P-value = 0.976 for SCZ	No significant association was observed in SZ.	Negative
SZ	rs1170099 - rs9566940	A-C	DGKH	Haplotypic association:P-value = 0.364, permutated P-value = 0.993 for SCZ	No significant association was observed in SZ.	Negative
SZ	rs1170099 - rs9566940	A-T	DGKH	Haplotypic association:P-value = 0.179, permutated P-value = 0.859 for SCZ	No significant association was observed in SZ.	Negative
SZ	rs1170099 - rs9566940	G-T	DGKH	Haplotypic association:P-value = 0.0002, permutated P-value = 0.002 for SCZ	Significant association was observed in SZ.	Positive
SZ	rs716934 - rs9566931 - rs9315897 - rs2122246	A-A-C-G	DGKH	Haplotypic association:P-value = 1, permutated P-value = 1 for SCZ	No significant association was observed in SZ.	Negative
MDD	rs9315885 - rs9532988 - rs1012053	C-A-C	DGKH	Haplotypic association:P-value > 0.05 for MDD	No significant association was observed in MDD.	Negative
MDD	rs9315885 - rs9532988 - rs1012053	C-A-A	DGKH	Haplotypic association:P-value > 0.05 for MDD	No significant association was observed in MDD.	Negative
MDD	rs9315885 - rs9532988 - rs1012053	T-G-A	DGKH	Haplotypic association:P-value > 0.05 for MDD	No significant association was observed in MDD.	Negative
MDD	rs9315885 - rs9532988 - rs1012053	T-A-A	DGKH	Haplotypic association:P-value > 0.05 for MDD	No significant association was observed in MDD.	Negative
MDD	rs716934 - rs9566931 - rs9315897 - rs2122246	A-A-T-G	DGKH	Haplotypic association:P-value > 0.05 for MDD	No significant association was observed in MDD.	Negative
MDD	rs716934 - rs9566931 - rs9315897 - rs2122246	T-A-T-A	DGKH	Haplotypic association:P-value > 0.05 for MDD	No significant association was observed in MDD.	Negative
MDD	rs716934 - rs9566931 - rs9315897 - rs2122246	T-A-T-G	DGKH	Haplotypic association:P-value > 0.05 for MDD	No significant association was observed in MDD.	Negative
MDD	rs716934 - rs9566931 - rs9315897 - rs2122246	T-G-T-G	DGKH	Haplotypic association:P-value > 0.05 for MDD	No significant association was observed in MDD.	Negative
MDD	rs1170099 - rs9566940	A-C	DGKH	Haplotypic association:P-value > 0.05 for MDD	No significant association was observed in MDD.	Negative
MDD	rs1170099 - rs9566940	A-T	DGKH	Haplotypic association:P-value > 0.05 for MDD	No significant association was observed in MDD.	Negative
MDD	rs1170099 - rs9566940	G-T	DGKH	Haplotypic association:P-value > 0.05 for MDD	No significant association was observed in MDD.	Negative
MDD	rs716934 - rs9566931 - rs9315897 - rs2122246	A-A-C-G	DGKH	Haplotypic association:P-value > 0.05 for MDD	No significant association was observed in MDD.	Negative

Genes reported by this study for SZ/MDD

Disease	Gene	Description	Result Category
SZ	DGKH	In summary, our results support DGKH as shared risk factor of BPD and SCZ in the Chinese Han population.	Positive
MDD	DGKH	Results for major depressive disorder were totally negative. There was no nominally significant allelic or haplotypic association in any of the analyses.	Negative