SNP Report

Basic Info

Name	rs11655548 dbSNP Ensembl
Location	chrCHR_HSCHR17_2_CTG2:1283483 - 1283483(1)
Variant Alleles	T/C
Ancestral Allele	T
Minor Allele	C
Minor Allele Frequence	0.330671
Functional Annotation	intron_variant; NMD_transcript_variant; non_coding_transcript_variant.
Consequence to Transcript	intron_variant(ENST00000264335, ENST00000469398, ENST00000486241, ENST00000489287, ENST00000571732, ENST00000573026, ENST00000573196, ENST00000575977); NMD_transcript_variant(ENST00000573196); non_coding_transcript_variant(ENST00000469398, ENST00000486241, ENST00000489287, ENST00000616643, ENST00000626999, ENST00000627099, ENST00000627231, ENST00000628106, ENST00000630045, ENST00000630606, ENST00000630699, ENST00000630606, ENST00000627099, ENST00000630045, ENST00000630699)
No. of Studies	1 (Positive: 0; Negative: 1; Trend: 0)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	YES

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Liu, J,2011(b)	G/T		For BD: allele, OR[95%CI]=0.99[0.87-1.12], P-value = 0.8782,...... For BD: allele, OR[95%CI]=0.99[0.87-1.12], P-value = 0.8782, P-permutation=1; genotype, P-value = 0.9883, P-permutation=1 More...	No significant association was observed. No significant association was observed.	Negative

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon	17p13.3	1(0/1/0)

SNPs in LD with rs11655548 (count: 7) View in gBrowse (chrCHR_HSCHR17_2_CTG2:1266957..1309732 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Functional Annotation	r²[population]
rs7214541	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant	0.815[CHB]; 0.831[CHD]
rs4790347	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	0.814[CHD]
rs7213811		0.895[CHB]; 0.901[CHD]; 0.84[JPT]
rs10521112	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	0.814[CHD]
rs7210877	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant	0.853[CHB]
rs4790084	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	0.834[CHD]
rs4790082	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	0.834[CHD]

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Liu, J,2011(b)	For SZ:allele, OR[95%CI]=0.94[0.83-1.07], P-value = 0.33275, P-permutation=0.9925;genotype, P-value = 0.53898, P-permutation=1	No significant association was observed.	Negative

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Liu, J,2011(b)	For MDD:allele, OR[95%CI]=0.94[0.83-1.07], P-value = 0.36063, P-permutation=0.9959;genotype, P-value = 0.63938, P-permutation=1	No significant association was observed.	Negative