Meta-analysis Report

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Basic Info

Reference	Tan, J., 2014 PMID: 24447945
Citation	Tan, J., et al. (2014). "Association between DAOA gene polymorphisms and the risk of schizophrenia, bipolar disorder and depressive disorder." Prog Neuropsychopharmacol Biol Psychiatry 51C: 89-98.
Disease Type	Bipolar Disorder & Schizophrenia & MDD
Study Type	Candidate-gene association study

Detail Info

Samples	46 published studies up to July 2013, including 17,515 cases and 25,189 controls..
Statistic Method	The distributions of genotypes were tested for Hardyâ€“Weinberg equilibriumin control groups. Six genetic models were applied to calculate the pooled ORs and 95% confidence intervals (CI) with either the fixed-effects (FE) model or the random-effects (RE) model depending on heterogeneity: allele frequencies model (A-allele vs. a-allele), dominant model (AA+Aa vs. aa), recessive model (AA vs. Aa+aa), co-dominant model 1 (AA vs. Aa), co-dominant model 2 (Aa vs. aa), and homozygous genes model (AA vs. aa). The heterogeneity between studies was assessed by Cochran's chi-square-based Q statistic and the inconsistency index (I2), and was considered statistically significant if P b 0.10 or I2 N 50%. Stratified analyses were performed with stratification of ethnicity to estimate the separate associations. The funnel plot and Egger's test were applied for publication bias. Reliable evidences of publication bias were an asymmetric funnel plot and a P value of Egger's test below 0.05. Sensitivity analyses were performed by removing each study in turn and calculating the remaining pooled ORs and 95% CI. Cumulative meta-analyses in which studies were assorted chronologically according to publication year were conducted to estimate the trend of pooled ORs as evidence accumulated. All analyses were accomplished with the Stata Statistical Package (Version 11.0).
Basic Result	DAOA genetic polymorphisms (M15, M18 and M23) were not found to confer a statistically significant increased risk of SCZ, BD or DD in the overall sample, or in Caucasians and Asians following subgroup analysis.

Genetic factors reported by this study for BD

SNPs reported by this study for BD (count: 3)

SNP	Related Gene(s)	Allele Change	Statistical Values	Author Comments	Result Category
rs2391191	DAOA DAOA-AS1	A/G	A vs. G: OR= 1.00; 95% CI= 0.95â€“1.07; P-value= 0.831	We did not obtain a significant association between M15 and ...... We did not obtain a significant association between M15 and BD. The combined samples revealed no significant heterogeneity. More...	Negative
rs3918342	DAOA	T/C	T vs. C: OR = 0.97, 95% CI = 0.87â€“1.08, P-value = 0.535	We did not obtain a significant association between M23 and ...... We did not obtain a significant association between M23 and BD. More...	Negative
rs947267	DAOA DAOA-AS1	C/A	C vs. A: OR= 0.98; 95%CI= 0.89â€“1.09; P-value = 0.739	We failed to obtain a significant association between M18 an...... We failed to obtain a significant association between M18 and BD More...	Negative

Genes reported by this study for BD (count: 1)

Gene	Statistical Values/Author Comments	Result Category
DAOA	DAOA genetic polymorphisms (M15, M18 and M23) were not found to confer a statistically significant i...... DAOA genetic polymorphisms (M15, M18 and M23) were not found to confer a statistically significant increased risk of SCZ, BD or DD in the overall sample, or in Caucasians and Asians following subgroup analysis. More...	Negative

Genetic factors reported by this study for SZ and/or MDD

SNPs reported by this study for SZ/MDD

Disease	SNP	Related Gene(s)	Statistical Values	Description	Result Category
SZ	rs3918342	DAOA	T vs. C: OR= 0.99, 95% CI= 0.92â€“1.08, P-value= 0.893; TT+TC vs. CC: OR= 0.97, 95% CI= 0.87â€“1.08, P-value = 0.633; TT vs. TC+CC: OR= 1.03, 95% CI= 0.91â€“1.17, P-value = 0.6; TT vs. TC: OR = 1.03, 95%CI = 0.93â€“1.15, P-value = 0.532; TC vs. CC: OR = 0.96, 95%CI = 0.89â€“1.02, P-value = 0.202; TT vs. CC: OR= 1.01, 95% CI= 0.86â€“1.19, P-value = 0.893.	The pooled ORs failed to indicate that M23 was significantly associated with SCZ in six models.	Negative
SZ	rs2391191	DAOA DAOA-AS1	A vs. G: OR=0.99, 95% CI= 0.94â€“1.05, P-value= 0.829; AA+AG vs. GG: OR=0.99, 95% CI= 0.91â€“1.08, P-value= 0.825; AA vs. AG+GG: OR= 1.01, 95% CI = 0.98â€“1.17, P-value= 0.806; AA vs. AG: OR = 1.01, 95% CI = 0.94â€“1.08, p = 0.764; AG vs. GG: OR = 0.99, 95% CI = 0.94â€“1.06, P-value= 0.872; AA vs. GG: OR>= 0.98, 95% CI= 0.87â€“1.11, P-value= 0.768.	The pooled ORs failed to indicate thatM15 was significantly associated with an increased risk of SCZ in six models	Negative
SZ	rs947267	DAOA DAOA-AS1	C vs. A: OR = 1.00, 95% CI = 0.89â€“1.11, P-value = 0.98; CC+CA vs. AA: OR = 0.97, 95% CI = 0.84â€“1.12, P-value = 0.675; CC vs. CA+AA: OR = 1.00, 95% CI= 0.87â€“1.15, P-value = 0.998; CC vs. CA: OR=1.01, 95% CI= 0.88â€“1.17, P-value = 0.864; CA vs. AA: OR= 0.97, 95%CI= 0.87â€“1.08, P-value = 0.584; CC vs. AA: OR= 0.98, 95% CI= 0.78â€“1.24, P-value = 0.857	The pooled ORs failed to suggest that M18 was significantly associated with SCZ in six models	Negative
MDD	rs3918342	DAOA	T vs. C: OR = 0.93; 95% CI = 0.83â€“1.03; P-value = 0.179	Significant association between M23 and DD was not found.	Negative
MDD	rs2391191	DAOA DAOA-AS1	A vs. G: OR = 0.98; 95% CI = 0.77â€“1.24; P-value = 0.855	No significant association was found between M15 and DD.	Negative
MDD	rs947267	DAOA DAOA-AS1	C vs. A: OR= 1.05, 95% CI = 0.91â€“1.22, P-value = 0.476; CC+CA vs. AA: OR = 1.09, 95%CI = 0.88â€“1.34, P-value = 0.43; CC vs. CA+AA: OR = 1.05, 95% CI = 0.79â€“1.40, P-value = 0.748; CC vs. CA: OR = 1.01, 95% CI = 0.75â€“1.37, P-value = 0.941; CA vs. AA: OR = 1.08, 95% CI = 0.87â€“1.35, P-value = 0.475; CC vs. AA: OR= 1.10, 95% CI= 0.80â€“1.51, P-value = 0.544.	No significant association was found between M18 and DD in six models.	Negative

Genes reported by this study for SZ/MDD

Disease	Gene	Description	Result Category
SZ	DAOA	DAOA genetic polymorphisms (M15, M18 andM23) were not found to confer a statistically significant increased risk of SCZ, BD or DD in the overall sample, or in Caucasians and Asians following subgroup analysis.	Negative
MDD	DAOA	DAOA genetic polymorphisms (M15, M18 andM23) were not found to confer a statistically significant increased risk of SCZ, BD or DD in the overall sample, or in Caucasians and Asians following subgroup analysis.	Negative