Gene Report

Basic Info
Approved Symbol KLK8
Previous Symbol PRSS19
Symbol Alias HNP, TADG14, neuropsin, ovasin
Approved Name kallikrein-related peptidase 8
Previous Name kallikrein 8 (neuropsin/ovasin)
Location 19q13
Position chr19:50996007-51002711, -1
External Links HGNC: 6369
Entrez Gene: 11202
Ensembl: ENSG00000129455
UCSC: uc002pur.1
No. of Studies 1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Izumi, A., 2008 SNP: rs1612902, rs1701946, rs1701947, rs1722550, rs55909231 Genetic variation of the hNP gene may contribute to molecular mechanisms of bipolar disorder and some aspects of memory and intelligence. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 14)

GO terms by PBA (count: 0)

GO terms by database search (count: 14)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors
Gene related SNPs (count: 21)

Literature-origin SNPs (count: 5)

LD-proxies (count: 16)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Overlap with MDD from candidate gene intersection analysis (count: 0)

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Region: chr19:50996007..51002711 View in gBrowse
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