SNP Report

Basic Info

Name	rs10095694 dbSNP Ensembl
Location	chr8:32642221 - 32642221(1)
Variant Alleles	T/C
Ancestral Allele	C
Minor Allele	T
Minor Allele Frequence	0.359824
Functional Annotation	intron_variant; non_coding_transcript_variant.
Consequence to Transcript	intron_variant(ENST00000287842, ENST00000356819, ENST00000405005, ENST00000518104, ENST00000518206, ENST00000519301, ENST00000520407, ENST00000521670, ENST00000522569, ENST00000523079, ENST00000523534, ENST00000631040); non_coding_transcript_variant(ENST00000522569)
No. of Studies	1 (Positive: 1; Negative: 0; Trend: 0)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	NO

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Thomson, P. A., 2007			Individual P-value = 0.039 for BP, Individual P-value = 0.00...... Individual P-value = 0.039 for BP, Individual P-value = 0.006 for SCZ and BP More...	This marker is nominally significant in the combined sample This marker is nominally significant in the combined sample	Positive

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
NRG1	neuregulin 1	8p12	15(10/5/0)

SNPs in LD with rs10095694 (count: 2) View in gBrowse (chr8:32635066..32643507 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Literature-origin SNPs with LD	Functional Annotation	r²[population]
rs7012689		intron_variant; non_coding_transcript_variant; upstream_gene_variant	0.96[CEU]
rs10098373		intron_variant; non_coding_transcript_variant	0.885[CEU]

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Thomson, P. A., 2007	Individual P-value = 0.0087 for SCZ , Individual P-value = 0.006 for SCZ and BP	This marker is nominally significant in the combined sample	Positive

Overlap with MDD from cross-disorder studies (count: 0)