BDgene

SNP Report

Basic Info
Name rs1612902 dbSNP Ensembl
Location chr19:50995939 - 50995939(1)
Variant Alleles T/C
Ancestral Allele C
Minor Allele C
Minor Allele Frequence 0.386781
Functional Annotation downstream_gene_variant; intron_variant; non_coding_transcript_variant.
Consequence to Transcript downstream_gene_variant(ENST00000250366, ENST00000291726, ENST00000320838, ENST00000347619, ENST00000391806, ENST00000593490, ENST00000594669, ENST00000594914, ENST00000595238, ENST00000598195, ENST00000599166, ENST00000599710, ENST00000600767); intron_variant(ENST00000594512); non_coding_transcript_variant(ENST00000594512)
No. of Studies 1 (Positive: 1; Negative: 0; Trend: 0)
Source Literature
Overlap with SZ? YES
Overlap with MDD? YES

SNP related studies (count: 1)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Izumi, A., 2008 g. A5229>G Genotype frequency (df=2) X2=9.82 , P value=0.007...... Genotype frequency (df=2) X2=9.82 , P value=0.0073 . Allele frequency (df=1) X2=10.07 , P value=0.0015 in Patients with BD vs controls. More... A significant allelic association was found between SNP and ...... A significant allelic association was found between SNP and bipolar disorder More... Positive

SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
KLK8 kallikrein-related peptidase 8 19q13 1(1/0/0)

SNPs in LD with rs1612902 (count: 12) View in gBrowse (chr19:50992430..51011889 )
The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 12)


Overlap with SZ from cross-disorder studies (count: 1)
Reference Statistical Result Description Result Category
Izumi, A., 2008 Genotype frequency (df=2) X2=2.25, P value=0.32. Allele frequency (df=1) X2=2.13, P value=0.14 in Patients with SZ vs controls. There was no significant difference in genotype or allele distribution for any SNP between patients and controls for schizophrenia or major depression. Negative

Overlap with MDD from cross-disorder studies (count: 1)
Reference Statistical Result Description Result Category
Izumi, A., 2008 Genotype frequency (df=2) X2=0.56, P value=0.75 . Allele frequency (df=1) X2=0.56, P value=0.45 in Patients with MD vs controls. There was no significant difference in genotype or allele distribution for any SNP between patients and controls for schizophrenia or major depression. Negative