BDgene

Study Report

Basic Info
Reference
Citation Steinberg, S., et al. (2012). "Common variant at 16p11.2 conferring risk of psychosis." Mol Psychiatry.
Disease Type Bipolar Disorder & Schizophrenia
Study Design case-control
Study Type Genome-wide association study
Sample Size Here we consider a mixed schizophrenia and bipolar disorder (psychosis) phenotype (addition of 7469 bipolar disorder cases, 1535 schizophrenia cases, 333 other psychosis cases, 808 unaffected family members and 46 160 controls)
Predominant Ethnicity

Detail Info

Genetic factors reported by this study for BD
SNPs reported by this study for BD (count: 9)

Genes reported by this study for BD (count: 4)

Genetic factors reported by this study for SZ and/or MDD
SNPs reported by this study for SZ/MDD
Disease SNP Related Gene(s) Statistical Values Description Result Category
SZ rs9960767 TCF4 TCF7L2 Association results in schizophrenia follow-up samples(10,671 cases; 23,900 controls):OR(95% CI) = 1.14 (1.06, 1.23),P-value = 0.00057 No significant association was observed. Negative
SZ rs4309482 TCF7L2 Association results in schizophrenia follow-up samples(10,671 cases; 23,900 controls):OR(95% CI) = 1.08 (1.04, 1.12),P-value = 1.7 x 10-5 No significant association was observed. Negative
SZ rs3131296 NOTCH4 Association results in schizophrenia follow-up samples(10,671 cases; 23,900 controls):OR(95% CI) = 1.15 (1.08, 1.21),P-value = 1.4 x 10-6 Suggestive association was found. Trend
SZ rs13211507 PGBD1 Association results in schizophrenia follow-up samples(10,671 cases; 23,900 controls):OR(95% CI) = 1.22 (1.14, 1.31),P-value = 5.2 x 10-9 The SNP showed a significant association with SZ. Positive
SZ rs4583255 TMEM219 TAOK2 Association results in schizophrenia follow-up samples(10,671 cases; 23,900 controls):OR(95% CI) = 1.06 (1.02, 1.10),P-value = 0.0011 No significant association was observed. Negative
SZ rs12807809 NRGN Association results in schizophrenia follow-up samples(10,671 cases; 23,900 controls):OR(95% CI) = 1.09 (1.04, 1.15),P-value = 0.00034 No significant association was observed. Negative
SZ rs2312147 VRK2 Association results in schizophrenia follow-up samples(10,671 cases; 23,900 controls):OR(95% CI) = 1.07 (1.03, 1.11),P-value = 0.00023 No significant association was observed. Negative
SZ rs6932590 POM121L2 Association results in schizophrenia follow-up samples(10,671 cases; 23,900 controls):OR(95% CI) = 1.10 (1.05, 1.14),P-value = 2.5 x 10-5 No significant association was observed. Negative
SZ rs6913660 HIST1H2BJ Association results in schizophrenia follow-up samples(10,671 cases; 23,900 controls):OR(95% CI) = 1.11 (1.06, 1.17),P-value = 2.3 x 10-5 No significant association was observed. Negative

Genes reported by this study for SZ/MDD
Disease Gene Description Result Category
SZ TAOK2 Association results in schizophrenia follow-up samples(10,671 cases; 23,900 controls):OR(95% CI) = 1.06 (1.02, 1.10),P-value = 0.0011. No significant association was observed. Negative
SZ VRK2 Association results in schizophrenia follow-up samples(10,671 cases; 23,900 controls):OR(95% CI) = 1.07 (1.03, 1.11),P-value = 0.00023. No significant association was observed. Negative
SZ NRGN Association results in schizophrenia follow-up samples(10,671 cases; 23,900 controls):OR(95% CI) = 1.09 (1.04, 1.15),P-value = 0.00034. No significant association was observed. Negative
SZ TCF4 Association results in schizophrenia follow-up samples(10,671 cases; 23,900 controls):OR(95% CI) = 1.08 (1.04, 1.12),P-value = 1.7 x 10-5. No significant association was observed. Negative