BDgene

SNP Report

Basic Info
Name rs4746720 dbSNP Ensembl
Location chr10:67917073 - 67917073(1)
Variant Alleles T/C
Ancestral Allele T
Minor Allele C
Minor Allele Frequence 0.115615
Functional Annotation 3_prime_UTR_variant; downstream_gene_variant.
Consequence to Transcript 3_prime_UTR_variant(ENST00000212015, ENST00000403579, ENST00000406900, ENST00000432464); downstream_gene_variant(ENST00000277817, ENST00000395198, ENST00000412272)
No. of Studies 1 (Positive: 0; Negative: 1; Trend: 0)
Source Literature
Overlap with SZ? YES
Overlap with MDD? NO

SNP related studies (count: 1)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Kishi, T.,2011(a) T/C For BP, X2 test: genotype, X2(2df)=2.2...... For BP, X2 test: genotype, X2(2df)=2.27, P-value = 0.322; allele, X2(2df)=0.97, P-value = 0.325 More... No significant association was observed. No significant association was observed. Negative

SNP related genes (count: 2)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 10q21.3 Mapped by Literature SNP
SIRT1 sirtuin 1 10q21 1(0/1/0)

SNPs in LD with rs4746720 (count: 4) View in gBrowse (chr10:67838066..67917073 )
The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 4)


Overlap with SZ from cross-disorder studies (count: 1)
Reference Statistical Result Description Result Category
Kishi, T.,2011(a) For SZ, X2 test:genotype, X2(2df)=8.07, P-value = 0.0177, corrected P-value = 0.142;allele, X2(2df)=6.75, P-value = 0.00947, , corrected P-value = 0.0758 Significant association was observed in SZ. Positive

Overlap with MDD from cross-disorder studies (count: 0)