BDgene

Study Report

Basic Info
Reference
Citation Papiol, S., A. Rosa, et al. (2004). "Interleukin-1 cluster is associated with genetic risk for schizophrenia and bipolar disorder." J Med Genet 41(3): 219-223.
Disease Type Bipolar Disorder & Schizophrenia
Study Design case-control
Study Type Candidate-gene association study
Sample Size 78 schizophrenic patients, 88 bipolar disorder patients, and 176 healthy controls.
SNP/Region/Marker Size 2 variants
Predominant Ethnicity
Population Spanish
Age Group Adults : Mean age(SD)(year):44.8(14.9) for BD patients,31.1(7.5) for SZ patients and 39.82(10.35) for controls

Detail Info

Genetic factors reported by this study for BD
SNPs reported by this study for BD (count: 1)

Haplotypes reported by this study for BD (count: 1)

Other variants reported by this study for BD (count: 1)

Genes reported by this study for BD (count: 2)

Gene-gene interactions reported by this study for BD (count: 1)

Genetic factors reported by this study for SZ and/or MDD
SNPs reported by this study for SZ/MDD
Disease SNP Related Gene(s) Statistical Values Description Result Category
SZ rs16944 IL1B Association analysis:chi square test, Schizophrenia v controls: allele: chi square= 3.79, P-value = 0.051; OR = 1.50 (95% CI: 0.98 to 2.31); genotype: chi square= 4.26, P-value = 0.119. No significant association was observed in SZ. Negative

Haplotypes reported by this study for SZ/MDD
Disease Markers Haplotype Related Gene(s)/Region(s) Statistical Values Description Result Category
SZ rs16944 - (IL1RN_intron 2_VNTR) C-VNTR(A2) IL1B IL1RN Haplotype analysis:Schizophrenia v controls: chi square= 12.70, global P-value = 0.012; chi square= 9.99, individual P-value = 0.0015; OR = 2.49(95% CI: 1.33 to 4.64). Significant association was found in SZ. Positive

Other variants reported by this study for SZ/MDD
Disease Variant Name Related Gene Type Statistical Values Description Result Category
SZ IL1RN intron 2 VNTR IL1RN VNTR Association analysis:chi square test, Schizophrenia v controls: allele: chi square= 0.33, P-value = 0.84; genotype: chi square= 1.62, P-value = 0.65. No significant association was observed in SZ. Negative

Genes reported by this study for SZ/MDD
Disease Gene Description Result Category
SZ IL1RN IL-1 cluster genetic variability may represent a shared genetic susceptibility factor both for schizophrenia and bipolar disorder. Positive
SZ IL1B IL-1 cluster genetic variability may represent a shared genetic susceptibility factor both for schizophrenia and bipolar disorder. Positive

Gene-gene interactions reported by this study for SZ/MDD
Disease Gene Group Markers Statistical Values Description Result Category
SZ rs16944 - (IL1RN_intron 2_VNTR) Haplotype analysis:Schizophrenia v controls: chi square= 12.70, global P-value = 0.012; chi square= 9.99, individual P-value = 0.0015; OR = 2.49(95% CI: 1.33 to 4.64). Significant association was found in SZ. Positive