Gene Report

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Basic Info

Approved Symbol	AS3MT
Symbol Alias	CYT19
Approved Name	arsenite methyltransferase
Previous Name	arsenic (+3 oxidation state) methyltransferase
Location	10q24.33
Position	chr10:102869516-102901899, 1
External Links	HGNC: 17452 Entrez Gene: 57412 Ensembl: ENSG00000214435 UCSC: uc001kwk.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Cross-Disorder Group of the Psychiatric Genomics Consortium,2013	SNP: rs11191454	Significant association was observed in cross-disorder analysis.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 9)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0032259	methylation	biological process	IBA	6
GO:0030792	methylarsonite methyltransferase activity	molecular function	ISS	1
GO:0005739	mitochondrion	cellular component	IEA	75
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	molecular function	IBA	1
GO:0009404	toxin metabolic process	biological process	ISS	1
GO:0005737	cytoplasm	cellular component	IBA	322
GO:0005829	cytosol	cellular component	ISS	223
GO:0018872	arsonoacetate metabolic process	biological process	ISS	1
GO:0030791	arsenite methyltransferase activity	molecular function	ISS	1

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 5)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs11191454	chr10:102900247 - 102900247(1)	intron_variant; NMD_transcript_variant	1(1/0/0)

rs_ID	Location	Functional Annotation
rs11191425	chr10:102866213 - 102866213(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; upstream_gene_variant
rs7098825	chr10:102868477 - 102868477(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant
rs3740390	chr10:102878723 - 102878723(1)	intron_variant; NMD_transcript_variant
rs11191447	chr10:102892566 - 102892566(1)	intron_variant; NMD_transcript_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 10	chr10:0-133797422	3 (0/2/1)
10q24	chr10:95300000-104000000	4 (0/2/2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
23453885	Significant association was observed in cross-disorder analysis.	Positive

Gene relationship with MDD

Reference	Description	Category in MDD
23453885	Significant association was observed in cross-disorder analysis.	Positive

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Region: chr10:102869516..102901899 View in gBrowse