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Study Report
| Comment on Study | View All Comments on Study |
Basic Info
| Reference | Severinsen, J. E., 2006 (a) PMID: 16741940 |
|---|---|
| Citation | Severinsen, J. E., T. D. Als, et al. (2006). "Association analyses suggest GPR24 as a shared susceptibility gene for bipolar affective disorder and schizophrenia." Am J Med Genet B Neuropsychiatr Genet 141B(5): 524-533. |
| Disease Type | Bipolar Disorder & Schizophrenia |
| Study Design | case-control |
| Study Type | Candidate-gene association study |
| Sample Size | a Faeroese sample of 28 distantly related cases and 44 controls, 4 newly ascertained cases, and a casecontrol sample from Scotland comprising 103 individuals with SZ, 162 with BPD, and 200 controls |
| SNP/Region/Marker Size | 10 variants |
| Predominant Ethnicity | Caucasian |
| Population | Faroese and Scottish |
Detail Info
| Sample Diagnosis | ICD10 and DSMIV for patients from the Faeroe Islands, SADS-L interview and RDC and DSM-IV for the case-control sample from Scotland |
|---|---|
| Sample Status | For patients from the Faeroe Islands, the genealogy of the distantly related 17 individuals with BPD and the 11 individuals with SZ was deduced from information on birth, marriages, and deaths in church and civic records of the Faeroese, and could be tracked back to a common ancestor born around 1600. The average number of generations relating two patients in the genealogically shortest possibly way through one of the parents were six for patients with SZ and seven for patients with BPD. The case-control sample from Scotland were diagnosed using SADS-L interview and RDC and DSM-IV criteria. |
| Technique | direct sequencing on an ABI310 Genetic Analyzer, and genotyping using the ABI SNaP-shot kit and an ABI 310 Genetic Analyzer or a 3100 Avant Genetic Analyzer |
| Statistical Method | The data from the six polymorphic SNPs genotyped in the Faeroese sample and the new D22S279 genotypes were merged with the D22S279 genotypes produced by Jorgensen et al., and a test of association was performed as implemented in CLUMP. T1 is the standard Pearson chi-square statistics of the 2 N contingency table and T4 is obtained by reshuffling alleles or haplotypes of a 2*2 table until chi-square has reached a maximum, thereby comparing any combination of alleles or haplotypes with the rest. In the analysis of specific haplotypes, test of associations were performed using Fisher's Exact test. For each of the seven polymorphic SNPs genotyped in the Scottish sample Chi-square and Fisher's Exact test were used to assess allele and genotype distribution and the program Haplotype Trend Regression (HTR) was used to estimate the frequency and analyze the distribution of haplotypes. |
| Result Summary | In both samples significant associations were observed in both disorders with predominantly GPR24 SNPs and haplotypes. In the Faeroese sample overall P-values of 0.0009, 0.0054, and 0.0023 were found for haplotypes in BPD, SZ, and combined cases, respectively, and in the Scottish sample overall P-values of 0.0003, 0.0005, and 0.016 were observed for similar groupings. Specific haplotypes showed associations with lowest P-values of 7 x 10(-5) and 0.0006 in the combined group of cases from the Faeroe Islands and Scotland, respectively. The G protein-coupled receptor 24 encoded by GPR24 binds melanin-concentrating hormone (MCH) and has been implicated with feeding behavior, energy metabolism, and regulation of stress and mood. To our knowledge this is the first study reporting association between GPR24 and BPD and SZ, suggesting that GPR24 variants may confer susceptibility to both disorders. |
Genetic factors reported by this study for BD
| SNP | Related Gene(s) | Allele Change | Risk Allele | Statistical Values | Author Comments | Result Category |
|---|---|---|---|---|---|---|
| rs133068 | MCHR1 GAPDHP37 | C/G | CLUMP T1 P-value = 0.8365, CLUMP T4 P-value = 0.8365 for BPD; CLUMP T1 P-value = 0.1461, CLUMP T4 P-value = 0.1461 for BPD and SZ in the Faeroese Sample; Empirical overall P-value = 0.6757 for BPD in the Case-Control Sample From Scotland; Empirical overall P-value = 0.8538 for BPD and SZ in the Case-Control Sample From Scotland | Negative | ||
| rs133070 | MCHR1 GAPDHP37 | A/G | CLUMP T1 P-value = 0.0195, CLUMP T4 P-value = 0.0195 for BPD; CLUMP T1 P-value = 0.0116, CLUMP T4 P-value = 0.0116 for BPD and SZ in the Faeroese Sample; Empirical overall P-value = 0.9373 for BPD in the Case-Control Sample From Scotland; Empirical overall P-value = 0.6721 for BPD and SZ in the Case-Control Sample From Scotland | In BPD and BPD/SZ combined, single marker association was ob...... In BPD and BPD/SZ combined, single marker association was observed for rs909669 (ADSL) and rs133070 (GPR24) with P-values between 0.0036 and 0.037. More... | Positive | |
| rs133069 | MCHR1 GAPDHP37 | C/A | CLUMP T1 P-value = 0.6815, CLUMP T4 P-value = 0.6815 for BPD; CLUMP T1 P-value = 0.074, CLUMP T4 P-value = 0.074 for BPD and SZ in the Faeroese Sample; Empirical overall P-value = 0.6748 for BPD in the Case-Control Sample From Scotland; Empirical overall P-value = 0.7126 for BPD and SZ in the Case-Control Sample From Scotland | Negative | ||
| rs1573745 | ST13 | G/A | Empirical overall P-value = 0.1588 for BPD in the Case-Control Sample From Scotland; Empirical overall P-value = 0.7989 for BPD and SZ in the Case-Control Sample From Scotland | Negative | ||
| rs133073 | MCHR1 | T/C | CLUMP T1 P-value = 0.4217, CLUMP T4 P-value = 0.4217 for BPD; CLUMP T1 P-value = 0.0546, CLUMP T4 P-value = 0.0546 for BPD and SZ in the Faeroese Sample; Empirical overall P-value = 0.347 for BPD in the Case-Control Sample From Scotland; Empirical overall P-value = 0.5632 for BPD and SZ in the Case-Control Sample From Scotland | Negative | ||
| rs909669 | ADSL | C/T | CLUMP T1 P-value = 0.0373, CLUMP T4 P-value = 0.0373 for BPD; CLUMP T1 P-value = 0.0036, CLUMP T4 P-value = 0.0036 for BPD and SZ in the Faeroese Sample; Empirical overall P-value = 0.6833 for BPD in the Case-Control Sample From Scotland; Empirical overall P-value = 0.2189 for BPD and SZ in the Case-Control Sample From Scotland | In BPD and BPD/SZ combined, single marker association was ob...... In BPD and BPD/SZ combined, single marker association was observed for rs909669 (ADSL) and rs133070 (GPR24) with P-values between 0.0036 and 0.037. More... | Positive | |
| rs710193 | ST13 | C/T | CLUMP T1 P-value = 1, CLUMP T4 P-value = 1 for BPD; CLUMP T1 P-value = 0.7631, CLUMP T4 P-value = 0.7631 for BPD and SZ in the Faeroese Sample; Empirical overall P-value = 0.3292 for BPD in the Case-Control Sample From Scotland; Empirical overall P-value = 0.2317 for BPD and SZ in the Case-Control Sample From Scotland | Negative |
| Markers | Haplotype | Related Gene(s)/Region(s) | Statistical Values | Author Comments | Result Category |
|---|---|---|---|---|---|
| D22S279 - rs133068 - rs133069 - rs133070 - rs133073 | 7-C-C-A-T | MCHR1 | CLUMP P-value = 0.2868 in BPD, P-value = 0.0139 in BPD and SZ; risk haplotype | Positive | |
| D22S279 - rs909669 | ADSL | CLUMP T1 P-value = 0.0805, CLUMP T4 P-value = 0.0501 in BPD and SZ, CLUMP T1 P-value = 0.4799, CLUMP T4 P-value = 0.3873 in BPD; Empirical overall P-value = 0.049 in BPD and SZ, Empirical overall P-value = 0.058 in BPD | Similarly, comparing controls to the combined group of cases...... Similarly, comparing controls to the combined group of cases revealed significant associations with 2-, 3-, 4-, and 5-marker haplotypes spanning the SNPs in GPR24 as well as rs909669 in ADSL. More... | Positive | |
| rs909669 - D22S279 - rs133068 - rs133069 - rs133070 | C-6/7-C-C-A | MCHR1 ADSL | CLUMP P-value = 0.0026 in BPD, P-value = 7E-05 in BPD and SZ; risk haplotype | Positive | |
| rs909669 - D22S279 - rs133068 - rs133069 - rs133070 | C-6-C-C-A | MCHR1 ADSL | CLUMP P-value = 0.0406 in BPD, P-value = 0.3176 in BPD and SZ; risk haplotype | Positive | |
| rs1573745 - rs710193 - rs133073 | ST13 MCHR1 | Empirical overall P-value = 0.0632 in BPD and SZ, Empirical overall P-value = 0.123 in BPD | Negative | ||
| rs1573745 - rs710193 | ST13 | Empirical overall P-value = 0.4429 in BPD and SZ, Empirical overall P-value = 0.5903 in BPD | Negative | ||
| rs133069 - rs133068 - D22S279 - rs909669 | MCHR1 ADSL | CLUMP T1 P-value = 0.2672, CLUMP T4 P-value = 0.2064 in BPD and SZ, CLUMP T1 P-value = 0.7976, CLUMP T4 P-value = 0.5424 in BPD; Empirical overall P-value = 0.0591 in BPD and SZ, Empirical overall P-value = 0.5948 in BPD | Negative | ||
| rs133068 - D22S279 - rs909669 | MCHR1 ADSL | CLUMP T1 P-value = 0.4823, CLUMP T4 P-value = 0.3996 in BPD and SZ, CLUMP T1 P-value = 0.8745, CLUMP T4 P-value = 0.7353 in BPD; Empirical overall P-value = 0.0319 in BPD and SZ, Empirical overall P-value = 0.3278 in BPD | Similarly, comparing controls to the combined group of cases...... Similarly, comparing controls to the combined group of cases revealed significant associations with 2-, 3-, 4-, and 5-marker haplotypes spanning the SNPs in GPR24 as well as rs909669 in ADSL. More... | Positive | |
| rs909669 - D22S279 - rs133068 - rs133069 - rs133070 | C-7-C-C-A | MCHR1 ADSL | CLUMP P-value = 0.1179 in BPD, P-value = 0.0006 in BPD and SZ; risk haplotype | Positive | |
| rs133070 - rs133069 - rs133068 - D22S279 - rs909669 | MCHR1 ADSL | CLUMP T1 P-value = 0.0059, CLUMP T4 P-value = 0.0031 in BPD and SZ, CLUMP T1 P-value = 0.2957, CLUMP T4 P-value = 0.1557 in BPD; Empirical overall P-value = 0.339 in BPD and SZ, Empirical overall P-value = 0.4471 in BPD | Positive | ||
| rs710193 - rs133073 - rs133070 - rs133069 - rs133068 | ST13 MCHR1 | CLUMP T1 P-value = 0.1722, CLUMP T4 P-value = 0.239 in BPD and SZ, CLUMP T1 P-value = 0.1745, CLUMP T4 P-value = 0.2831 in BPD; Empirical overall P-value = 0.1895 in BPD and SZ, Empirical overall P-value = 0.0018 in BPD | Positive | ||
| rs710193 - rs133073 - rs133070 - rs133069 | ST13 MCHR1 | CLUMP T1 P-value = 0.1755, CLUMP T4 P-value = 0.2417 in BPD and SZ, CLUMP T1 P-value = 0.1753, CLUMP T4 P-value = 0.2821 in BPD; Empirical overall P-value = 0.079 in BPD and SZ, Empirical overall P-value = 0.0252 in BPD | Positive | ||
| rs1573745 - rs710193 - rs133073 - rs133070 - rs133069 | ST13 MCHR1 | Empirical overall P-value = 0.2604 in BPD and SZ, Empirical overall P-value = 0.1587 in BPD | Negative | ||
| rs1573745 - rs710193 - rs133073 - rs133070 | ST13 MCHR1 | Empirical overall P-value = 0.1346 in BPD and SZ, Empirical overall P-value = 0.3998 in BPD | Negative | ||
| rs710193 - rs133073 - rs133070 | ST13 MCHR1 | CLUMP T1 P-value = 0.1158, CLUMP T4 P-value = 0.1697 in BPD and SZ, CLUMP T1 P-value = 0.085, CLUMP T4 P-value = 0.194 in BPD; Empirical overall P-value = 0.0715 in BPD and SZ, Empirical overall P-value = 0.2251 in BPD | Negative | ||
| rs710193 - rs133073 | ST13 MCHR1 | CLUMP T1 P-value = 0.4522, CLUMP T4 P-value = 0.4361 in BPD and SZ, CLUMP T1 P-value = 0.8264, CLUMP T4 P-value = 0.86 in BPD; Empirical overall P-value = 0.1247 in BPD and SZ, Empirical overall P-value = 0.1197 in BPD | Negative | ||
| rs133069 - rs133068 - D22S279 | MCHR1 | CLUMP T1 P-value = 0.2017, CLUMP T4 P-value = 0.2023 in BPD and SZ, CLUMP T1 P-value = 0.5063, CLUMP T4 P-value = 0.4663 in BPD; Empirical overall P-value = 0.3066 in BPD and SZ, Empirical overall P-value = 0.7233 in BPD | Negative | ||
| rs133069 - rs133070 | A-G | MCHR1 | CLUMP P-value = 0.0393 in BPD, P-value = 0.0364 in BPD and SZ; protective haplotype | The overall signal in BPD was strongest for 2- and 3-marker ...... The overall signal in BPD was strongest for 2- and 3-marker haplotypes involving rs133069 to rs133073. The same specific 2- and 3-marker haplotypes covering rs133069 to rs133073 as seen in BPD showed P-values as low as 0.0183 in the combined sample. More... | Positive |
| rs133069 - rs133070 - rs133073 | A-G-C | MCHR1 | CLUMP P-value = 0.0307 in BPD, P-value = 0.0526 in BPD and SZ; protective haplotype | The overall signal in BPD was strongest for 2- and 3-marker ...... The overall signal in BPD was strongest for 2- and 3-marker haplotypes involving rs133069 to rs133073. The same specific 2- and 3-marker haplotypes covering rs133069 to rs133073 as seen in BPD showed P-values as low as 0.0183 in the combined sample. More... | Positive |
| rs133070 - rs133069 | MCHR1 | CLUMP T1 P-value = 0.0145, CLUMP T4 P-value = 0.0828 in BPD and SZ, CLUMP T1 P-value = 0.003, CLUMP T4 P-value = 0.0159 in BPD; Empirical overall P-value = 0.4592 in BPD and SZ, Empirical overall P-value = 0.1855 in BPD | The strongest signal was centered on 2-marker haplotypes fro...... The strongest signal was centered on 2-marker haplotypes from rs133069 to rs133073 in GPR24. Similarly, comparing controls to the combined group of cases revealed significant associations with 2-, 3-, 4-, and 5-marker haplotypes spanning the SNPs in GPR24 as well as rs909669 in ADSL. More... | Positive | |
| D22S279 - rs133068 - rs133069 - rs133070 - rs133073 | 6-C-C-A-T | MCHR1 | CLUMP P-value = 0.034 in BPD, P-value = 0.2166 in BPD and SZ; risk haplotype | Positive | |
| D22S279 - rs133068 - rs133069 - rs133070 - rs133073 | 6/7-C-C-A-T | MCHR1 | CLUMP P-value = 0.0076 in BPD, P-value = 0.0005 in BPD and SZ; risk haplotype | Positive | |
| rs133068 - D22S279 | MCHR1 | CLUMP T1 P-value = 0.1818, CLUMP T4 P-value = 0.127 in BPD and SZ, CLUMP T1 P-value = 0.4893, CLUMP T4 P-value = 0.5473 in BPD; Empirical overall P-value = 0.1821 in BPD and SZ, Empirical overall P-value = 0.6295 in BPD | Negative | ||
| rs133069 - rs133068 | MCHR1 | CLUMP T1 P-value = 0.0716, CLUMP T4 P-value = 0.1107 in BPD and SZ, CLUMP T1 P-value = 0.6484, CLUMP T4 P-value = 0.5936 in BPD; Empirical overall P-value = 0.1791 in BPD and SZ, Empirical overall P-value = 0.3582 in BPD | Negative | ||
| rs133073 - rs133070 | MCHR1 | CLUMP T1 P-value = 0.004, CLUMP T4 P-value = 0.0188 in BPD and SZ, CLUMP T1 P-value = 0.0009, CLUMP T4 P-value = 0.0093 in BPD; Empirical overall P-value = 0.0262 in BPD and SZ, Empirical overall P-value = 0.1471 in BPD | The strongest signal was centered on 2-marker haplotypes fro...... The strongest signal was centered on 2-marker haplotypes from rs133069 to rs133073 in GPR24. Similarly, comparing controls to the combined group of cases revealed significant associations with 2-, 3-, 4-, and 5-marker haplotypes spanning the SNPs in GPR24 as well as rs909669 in ADSL. More... | Positive | |
| rs133073 - rs133070 - rs133069 - rs133068 - D22S279 | MCHR1 | CLUMP T1 P-value = 0.0063, CLUMP T4 P-value = 0.0023 in BPD and SZ, CLUMP T1 P-value = 0.1521, CLUMP T4 P-value = 0.1056 in BPD; Empirical overall P-value = 0.1747 in BPD and SZ, Empirical overall P-value = 0.041 in BPD | Similarly, comparing controls to the combined group of cases...... Similarly, comparing controls to the combined group of cases revealed significant associations with 2-, 3-, 4-, and 5-marker haplotypes spanning the SNPs in GPR24 as well as rs909669 in ADSL. More... | Positive | |
| rs133073 - rs133070 - rs133069 | MCHR1 | CLUMP T1 P-value = 0.0268, CLUMP T4 P-value = 0.0626 in BPD and SZ, CLUMP T1 P-value = 0.0042, CLUMP T4 P-value = 0.0303 in BPD; Empirical overall P-value = 0.0155 in BPD and SZ, Empirical overall P-value = 0.0053 in BPD | Similarly, comparing controls to the combined group of cases...... Similarly, comparing controls to the combined group of cases revealed significant associations with 2-, 3-, 4-, and 5-marker haplotypes spanning the SNPs in GPR24 as well as rs909669 in ADSL. More... | Positive | |
| rs133073 - rs133070 - rs133069 - rs133068 | MCHR1 | CLUMP T1 P-value = 0.0479, CLUMP T4 P-value = 0.1278 in BPD and SZ, CLUMP T1 P-value = 0.0433, CLUMP T4 P-value = 0.0997 in BPD; Empirical overall P-value = 0.0184 in BPD and SZ, Empirical overall P-value = 0.0003 in BPD | Similarly, comparing controls to the combined group of cases...... Similarly, comparing controls to the combined group of cases revealed significant associations with 2-, 3-, 4-, and 5-marker haplotypes spanning the SNPs in GPR24 as well as rs909669 in ADSL. More... | Positive | |
| rs133070 - rs133069 - rs133068 | MCHR1 | CLUMP T1 P-value = 0.0525, CLUMP T4 P-value = 0.1831 in BPD and SZ, CLUMP T1 P-value = 0.0316, CLUMP T4 P-value = 0.0972 in BPD; Empirical overall P-value = 0.5945 in BPD and SZ, Empirical overall P-value = 0.0779 in BPD | Similarly, comparing controls to the combined group of cases...... Similarly, comparing controls to the combined group of cases revealed significant associations with 2-, 3-, 4-, and 5-marker haplotypes spanning the SNPs in GPR24 as well as rs909669 in ADSL. More... | Positive | |
| rs133070 - rs133069 - rs133068 - D22S279 | MCHR1 | CLUMP T1 P-value = 0.0064, CLUMP T4 P-value = 0.0023 in BPD and SZ, CLUMP T1 P-value = 0.1531, CLUMP T4 P-value = 0.1076 in BPD; Empirical overall P-value = 0.3363 in BPD and SZ, Empirical overall P-value = 0.3612 in BPD | Similarly, comparing controls to the combined group of cases...... Similarly, comparing controls to the combined group of cases revealed significant associations with 2-, 3-, 4-, and 5-marker haplotypes spanning the SNPs in GPR24 as well as rs909669 in ADSL. More... | Positive | |
| rs133070 - rs133073 | A-C | MCHR1 | CLUMP P-value = 0.0048 in BPD, P-value = 0.0234 in BPD and SZ; risk haplotype | The overall signal in BPD was strongest for 2- and 3-marker ...... The overall signal in BPD was strongest for 2- and 3-marker haplotypes involving rs133069 to rs133073. The same specific 2- and 3-marker haplotypes covering rs133069 to rs133073 as seen in BPD showed P-values as low as 0.0183 in the combined sample. More... | Positive |
| rs133070 - rs133073 | G-C | MCHR1 | CLUMP P-value = 0.0165 in BPD, P-value = 0.0183 in BPD and SZ; protective haplotype | The overall signal in BPD was strongest for 2- and 3-marker ...... The overall signal in BPD was strongest for 2- and 3-marker haplotypes involving rs133069 to rs133073. The same specific 2- and 3-marker haplotypes covering rs133069 to rs133073 as seen in BPD showed P-values as low as 0.0183 in the combined sample. More... | Positive |
| Variant Name | Related Gene | Type | Allele Change | Risk Allele | Statistical Values | Author Comments | Result Category |
|---|---|---|---|---|---|---|---|
| D22S279 | microsatellite | CLUMP T1 P-value = 0.3548, CLUMP T4 P-value = 0.239 for BPD; CLUMP T1 P-value = 0.0705, CLUMP T4 P-value = 0.0268 for BPD and SZ in the Faeroese Sample; Empirical overall P-value = 0.5453 for BPD in the Case-Control Sample From Scotland; Empirical overall P-value = 0.4644 for BPD and SZ in the Case-Control Sample From Scotland | Positive |
| Gene | Statistical Values/Author Comments | Result Category |
|---|---|---|
| MCHR1 | Evidence from both samples suggested GPR24 as a susceptibility gene for both BPD and SZ. Evidence from both samples suggested GPR24 as a susceptibility gene for both BPD and SZ. | Positive |
| ST13 | 4-, 5- maker haplotypes spanning GPR24 and ST13 are associated with BD. 4-, 5- maker haplotypes spanning GPR24 and ST13 are associated with BD. | Positive |
| ADSL | one SNP and haplotypes are associated with BPD in this sample one SNP and haplotypes are associated with BPD in this sample | Positive |
| Gene Group | Markers | Statistical Values | Author Comments | Result Category |
|---|---|---|---|---|
| MCHR1 ADSL | rs133068 - D22S279 - rs909669; rs133069 - rs133068 - D22S279 - rs909669; rs133070 - rs133069 - rs133068 - D22S279 - rs909669; rs909669 - D22S279 - rs133068 - rs133069 - rs133070; rs909669 - D22S279 - rs133068 - rs133069 - rs133070; rs909669 - D22S279 - rs133068 - rs133069 - rs133070 | For markers "rs133068 - D22S279 - rs909669": CLUMP T1 P-value = 0.4823, CLUMP T4 P-value = 0.3996 in BPD and SZ, CLUMP T1 P-value = 0.8745, CLUMP T4 P-value = 0.7353 in BPD; Empirical overall P-value = 0.0319 in BPD and SZ, Empirical overall P-value = 0.3278 in BPD; For markers "rs133069 - rs133068 - D22S279 - rs909669": CLUMP T1 P-value = 0.2672, CLUMP T4 P-value = 0.2064 in BPD and SZ, CLUMP T1 P-value = 0.7976, CLUMP T4 P-value = 0.5424 in BPD; Empirical overall P-value = 0.0591 in BPD and SZ, Empirical overall P-value = 0.5948 in BPD; For markers "rs133070 - rs133069 - rs133068 - D22S279 - rs909669": CLUMP T1 P-value = 0.0059, CLUMP T4 P-value = 0.0031 in BPD and SZ, CLUMP T1 P-value = 0.2957, CLUMP T4 P-value = 0.1557 in BPD; Empirical overall P-value = 0.339 in BPD and SZ, Empirical overall P-value = 0.4471 in BPD; For haplotype "rs909669 - D22S279 - rs133068 - rs133069 - rs133070(C-7-C-C-A)": CLUMP P-value = 0.1179 in BPD, P-value = 0.0006 in BPD and SZ; For risk haplotype "rs909669 - D22S279 - rs133068 -rs133069 - rs133070(C-6-C-C-A)": CLUMP P-value = 0.0406 in BPD, P-value = 0.3176 in BPD and SZ; For risk haplotype "rs909669 - D22S279 - rs133068 - rs133069 - rs133070(C-6/7-C-C-A)": CLUMP P-value = 0.0026 in BPD, P-value = 7E-05 in BPD and SZ. | Similarly, comparing controls to the combined group of cases...... Similarly, comparing controls to the combined group of cases revealed significant associations with 2-, 3-, 4-, and 5-marker haplotypes spanning the SNPs in GPR24 as well as rs909669 in ADSL. More... | Positive |
| ST13 MCHR1 | rs710193 - rs133073; rs710193 - rs133073 - rs133070; rs710193 - rs133073 - rs133070 - rs133069; rs710193 - rs133073 - rs133070 - rs133069 - rs133068; rs1573745 - rs710193 - rs133073; rs1573745 - rs710193 - rs133073 - rs133070; rs1573745 - rs710193 - rs133073 - rs133070 - rs133069 | For markers "rs710193 - rs133073 - rs133070 - rs133069", CLUMP T1 P-value = 0.1755, CLUMP T4 P-value = 0.2417 in BPD and SZ, CLUMP T1 P-value = 0.1753, CLUMP T4 P-value = 0.2821 in BPD; Empirical overall P-value = 0.079 in BPD and SZ, Empirical overall P-value = 0.0252 in BPD.For markers "rs710193 - rs133073 - rs133070 - rs133069 - rs133068", CLUMP T1 P-value = 0.1722, CLUMP T4 P-value = 0.239 in BPD and SZ, CLUMP T1 P-value = 0.1745, CLUMP T4 P-value = 0.2831 in BPD; Empirical overall P-value = 0.1895 in BPD and SZ, Empirical overall P-value = 0.0018 in BPD. | Positive |
Genetic factors reported by this study for SZ and/or MDD
| Disease | SNP | Related Gene(s) | Statistical Values | Description | Result Category |
|---|---|---|---|---|---|
| SZ | rs133073 | MCHR1 | CLUMP T1 P-value = 0.0083, CLUMP T4 P-value = 0.0083 for SZ; CLUMP T1 P-value = 0.0546, CLUMP T4 P-value = 0.0546 for BPD and SZ in the Faeroese Sample; Empirical overall P-value = 0.8469 for SZ in the Case-Control Sample From Scotland; Empirical overall P-value = 0.5632 for BPD and SZ in the Case-Control Sample From Scotland | The three GPR24 SNPs rs133068, rs133069, and rs133073 showed association with SZ yielding P-values of 0.008-0.02. | Positive |
| SZ | rs1573745 | ST13 | Empirical overall P-value = 0.2879 for SZ in the Case-Control Sample From Scotland; Empirical overall P-value = 0.7989 for BPD and SZ in the Case-Control Sample From Scotland | Negative | |
| SZ | rs710193 | ST13 | CLUMP T1 P-value = 0.7065, CLUMP T4 P-value = 0.7065 for SZ; CLUMP T1 P-value = 0.7631, CLUMP T4 P-value = 0.7631 for BPD and SZ in the Faeroese Sample; Empirical overall P-value = 0.2758 for SZ in the Case-Control Sample From Scotland; Empirical overall P-value = 0.2317 for BPD and SZ in the Case-Control Sample From Scotland | Negative | |
| SZ | rs909669 | ADSL | CLUMP T1 P-value = 0.1178, CLUMP T4 P-value = 0.1178 for SZ; CLUMP T1 P-value = 0.0036, CLUMP T4 P-value = 0.0036 for BPD and SZ in the Faeroese Sample; Empirical overall P-value = 0.0655 for SZ in the Case-Control Sample From Scotland; Empirical overall P-value = 0.2189 for BPD and SZ in the Case-Control Sample From Scotland | In BPD and BPD/SZ combined, single marker association was observed for rs909669 (ADSL) and rs133070 (GPR24) with P-values between 0.0036 and 0.037. | Positive |
| SZ | rs133068 | MCHR1 GAPDHP37 | CLUMP T1 P-value = 0.0197, CLUMP T4 P-value = 0.0197 for SZ; CLUMP T1 P-value = 0.1461, CLUMP T4 P-value = 0.1461 for BPD and SZ in the Faeroese Sample; Empirical overall P-value = 0.8145 for SZ in the Case-Control Sample From Scotland; Empirical overall P-value = 0.8538 for BPD and SZ in the Case-Control Sample From Scotland | The three GPR24 SNPs rs133068, rs133069, and rs133073 showed association with SZ yielding P-values of 0.008-0.02. | Positive |
| SZ | rs133069 | MCHR1 GAPDHP37 | CLUMP T1 P-value = 0.01, CLUMP T4 P-value = 0.01 for SZ; CLUMP T1 P-value = 0.074, CLUMP T4 P-value = 0.074 for BPD and SZ in the Faeroese Sample; Empirical overall P-value = 0.8734 for SZ in the Case-Control Sample From Scotland; Empirical overall P-value = 0.7126 for BPD and SZ in the Case-Control Sample From Scotland | The three GPR24 SNPs rs133068, rs133069, and rs133073 showed association with SZ yielding P-values of 0.008-0.02. | Positive |
| SZ | rs133070 | MCHR1 GAPDHP37 | CLUMP T1 P-value = 0.2107, CLUMP T4 P-value = 0.2107 for SZ; CLUMP T1 P-value = 0.0116, CLUMP T4 P-value = 0.0116 for BPD and SZ in the Faeroese Sample; Empirical overall P-value = 0.3638 for SZ in the Case-Control Sample From Scotland; Empirical overall P-value = 0.6721 for BPD and SZ in the Case-Control Sample From Scotland | In BPD and BPD/SZ combined, single marker association was observed for rs909669 (ADSL) and rs133070 (GPR24) with P-values between 0.0036 and 0.037. | Positive |
| Disease | Markers | Haplotype | Related Gene(s)/Region(s) | Statistical Values | Description | Result Category |
|---|---|---|---|---|---|---|
| SZ | D22S279 - rs909669 | ADSL | CLUMP T1 P-value = 0.0805, CLUMP T4 P-value = 0.0501 in BPD and SZ, CLUMP T1 P-value = 0.0447, CLUMP T4 P-value = 0.008 in SZ; Empirical overall P-value = 0.049 in BPD and SZ, Empirical overall P-value = 0.0012 in SZ | Similarly, comparing controls to the combined group of cases revealed significant associations with 2-, 3-, 4-, and 5-marker haplotypes spanning the SNPs in GPR24 as well as rs909669 in ADSL. | Positive | |
| SZ | rs133069 - rs133068 - D22S279 | MCHR1 | CLUMP T1 P-value = 0.2017, CLUMP T4 P-value = 0.2023 in BPD and SZ, CLUMP T1 P-value = 0.187, CLUMP T4 P-value = 0.1727 in SZ; Empirical overall P-value = 0.3066 in BPD and SZ, Empirical overall P-value = 0.0005 in SZ | Similarly, comparing controls to the combined group of cases revealed significant associations with 2-, 3-, 4-, and 5-marker haplotypes spanning the SNPs in GPR24 as well as rs909669 in ADSL. | Positive | |
| SZ | rs133069 - rs133068 | MCHR1 | CLUMP T1 P-value = 0.0716, CLUMP T4 P-value = 0.1107 in BPD and SZ, CLUMP T1 P-value = 0.0469, CLUMP T4 P-value = 0.0353 in SZ; Empirical overall P-value = 0.1791 in BPD and SZ, Empirical overall P-value = 0.1238 in SZ | Similarly, comparing controls to the combined group of cases revealed significant associations with 2-, 3-, 4-, and 5-marker haplotypes spanning the SNPs in GPR24 as well as rs909669 in ADSL. | Positive | |
| SZ | rs133069 - rs133070 - rs133073 | A-G-C | MCHR1 | CLUMP P-value = 0.3279 in SZ, P-value = 0.0526 in BPD and SZ; protective haplotype | The same specific 2- and 3-marker haplotypes covering rs133069 to rs133073 as seen in BPD showed P-values as low as 0.0183 in the combined sample. | Negative |
| SZ | rs133069 - rs133070 | A-G | MCHR1 | CLUMP P-value = 0.3279 in SZ, P-value = 0.0364 in BPD and SZ; protective haplotype | The same specific 2- and 3-marker haplotypes covering rs133069 to rs133073 as seen in BPD showed P-values as low as 0.0183 in the combined sample. | Positive |
| SZ | D22S279 - rs133068 - rs133069 - rs133070 - rs133073 | 6-C-C-A-T | MCHR1 | CLUMP P-value = 1 in SZ, P-value = 0.2166 in BPD and SZ; risk haplotype | Negative | |
| SZ | D22S279 - rs133068 - rs133069 - rs133070 - rs133073 | 7-C-C-A-T | MCHR1 | CLUMP P-value = 0.0013 in SZ, P-value = 0.0139 in BPD and SZ; risk haplotype | Positive | |
| SZ | rs133068 - D22S279 | MCHR1 | CLUMP T1 P-value = 0.1818, CLUMP T4 P-value = 0.127 in BPD and SZ, CLUMP T1 P-value = 0.0542, CLUMP T4 P-value = 0.0476 in SZ; Empirical overall P-value = 0.1821 in BPD and SZ, Empirical overall P-value = 0.0054 in SZ | Positive | ||
| SZ | D22S279 - rs133068 - rs133069 - rs133070 - rs133073 | 6/7-C-C-A-T | MCHR1 | CLUMP P-value = 0.0013 in SZ, P-value = 0.0005 in BPD and SZ; risk haplotype | Positive | |
| SZ | rs133073 - rs133070 - rs133069 - rs133068 - D22S279 | MCHR1 | CLUMP T1 P-value = 0.0063, CLUMP T4 P-value = 0.0023 in BPD and SZ, CLUMP T1 P-value = 0.0432, CLUMP T4 P-value = 0.0375 in SZ; Empirical overall P-value = 0.1747 in BPD and SZ, Empirical overall P-value = 0.0189 in SZ | Negative | ||
| SZ | rs133073 - rs133070 - rs133069 | MCHR1 | CLUMP T1 P-value = 0.0268, CLUMP T4 P-value = 0.0626 in BPD and SZ, CLUMP T1 P-value = 0.3269, CLUMP T4 P-value = 0.3269 in SZ; Empirical overall P-value = 0.0155 in BPD and SZ, Empirical overall P-value = 0.0148 in SZ | Similarly, comparing controls to the combined group of cases revealed significant associations with 2-, 3-, 4-, and 5-marker haplotypes spanning the SNPs in GPR24 as well as rs909669 in ADSL. | Positive | |
| SZ | rs133070 - rs133073 | G-C | MCHR1 | CLUMP P-value = 0.3286 in SZ, P-value = 0.0183 in BPD and SZ; protective haplotype | The same specific 2- and 3-marker haplotypes covering rs133069 to rs133073 as seen in BPD showed P-values as low as 0.0183 in the combined sample. | Positive |
| SZ | rs133073 - rs133070 | MCHR1 | CLUMP T1 P-value = 0.004, CLUMP T4 P-value = 0.0188 in BPD and SZ, CLUMP T1 P-value = 0.5104, CLUMP T4 P-value = 0.5104 in SZ; Empirical overall P-value = 0.0262 in BPD and SZ, Empirical overall P-value = 0.1879 in SZ | Similarly, comparing controls to the combined group of cases revealed significant associations with 2-, 3-, 4-, and 5-marker haplotypes spanning the SNPs in GPR24 as well as rs909669 in ADSL. | Positive | |
| SZ | rs133070 - rs133069 - rs133068 - D22S279 | MCHR1 | CLUMP T1 P-value = 0.0064, CLUMP T4 P-value = 0.0023 in BPD and SZ, CLUMP T1 P-value = 0.0426, CLUMP T4 P-value = 0.0367 in SZ; Empirical overall P-value = 0.3363 in BPD and SZ, Empirical overall P-value = 0.0053 in SZ | Similarly, comparing controls to the combined group of cases revealed significant associations with 2-, 3-, 4-, and 5-marker haplotypes spanning the SNPs in GPR24 as well as rs909669 in ADSL. | Positive | |
| SZ | rs133070 - rs133073 | A-C | MCHR1 | CLUMP P-value = 1 in SZ, P-value = 0.0234 in BPD and SZ; risk haplotype | The same specific 2- and 3-marker haplotypes covering rs133069 to rs133073 as seen in BPD showed P-values as low as 0.0183 in the combined sample. | Positive |
| SZ | rs133070 - rs133069 | MCHR1 | CLUMP T1 P-value = 0.0145, CLUMP T4 P-value = 0.0828 in BPD and SZ, CLUMP T1 P-value = 0.3299, CLUMP T4 P-value = 0.3299 in SZ; Empirical overall P-value = 0.4592 in BPD and SZ, Empirical overall P-value = 0.0618 in SZ | Similarly, comparing controls to the combined group of cases revealed significant associations with 2-, 3-, 4-, and 5-marker haplotypes spanning the SNPs in GPR24 as well as rs909669 in ADSL. | Positive | |
| SZ | rs133070 - rs133069 - rs133068 | MCHR1 | CLUMP T1 P-value = 0.0525, CLUMP T4 P-value = 0.1831 in BPD and SZ, CLUMP T1 P-value = 0.4456, CLUMP T4 P-value = 0.4456 in SZ; Empirical overall P-value = 0.5945 in BPD and SZ, Empirical overall P-value = 0.0691 in SZ | Negative | ||
| SZ | rs909669 - D22S279 - rs133068 - rs133069 - rs133070 | C-6/7-C-C-A | MCHR1 ADSL | CLUMP P-value = 0.0002 in SZ, P-value = 7E-05 in BPD and SZ; risk haplotype | The specific 5-marker haplotype straddling rs909660 to rs133070 as seen inSZ (C7CCA) showed aP-value of 0.0006 in the combined sample, and together with a variant of this haplotype (C6CCA) the haplotypes C-6/7-CCA were over-represented in cases with a frequency of 75% against only 22% in controls. | Positive |
| SZ | rs1573745 - rs710193 | ST13 | Empirical overall P-value = 0.4429 in BPD and SZ, Empirical overall P-value = 0.1394 in SZ | Negative | ||
| SZ | rs909669 - D22S279 - rs133068 - rs133069 - rs133070 | C-7-C-C-A | MCHR1 ADSL | CLUMP P-value = 5E-06 in SZ, P-value = 0.0006 in BPD and SZ; risk haplotype | The specific 5-marker haplotype straddling rs909660 to rs133070 as seen inSZ (C7CCA) showed aP-value of 0.0006 in the combined sample, and together with a variant of this haplotype (C6CCA) the haplotypes C-6/7-CCA were over-represented in cases with a frequency of 75% against only 22% in controls. | Positive |
| SZ | rs909669 - D22S279 - rs133068 - rs133069 - rs133070 | C-6-C-C-A | MCHR1 ADSL | CLUMP P-value = 0.5569 in SZ, P-value = 0.3176 in BPD and SZ; risk haplotype | The specific 5-marker haplotype straddling rs909660 to rs133070 as seen inSZ (C7CCA) showed aP-value of 0.0006 in the combined sample, and together with a variant of this haplotype (C6CCA) the haplotypes C-6/7-CCA were over-represented in cases with a frequency of 75% against only 22% in controls. | Negative |
| SZ | rs133069 - rs133068 - D22S279 - rs909669 | MCHR1 ADSL | CLUMP T1 P-value = 0.2672, CLUMP T4 P-value = 0.2064 in BPD and SZ, CLUMP T1 P-value = 0.1481, CLUMP T4 P-value = 0.0495 in SZ; Empirical overall P-value = 0.0591 in BPD and SZ, Empirical overall P-value = 0.0012 in SZ | Similarly, comparing controls to the combined group of cases revealed significant associations with 2-, 3-, 4-, and 5-marker haplotypes spanning the SNPs in GPR24 as well as rs909669 in ADSL. | Positive | |
| SZ | rs133070 - rs133069 - rs133068 - D22S279 - rs909669 | MCHR1 ADSL | CLUMP T1 P-value = 0.0059, CLUMP T4 P-value = 0.0031 in BPD and SZ, CLUMP T1 P-value = 0.0156, CLUMP T4 P-value = 0.0054 in SZ; Empirical overall P-value = 0.339 in BPD and SZ, Empirical overall P-value = 0.0497 in SZ | When comparing controls to SZ unequal haplotype distribution was observed for 2-, 3-, 4-, and 5-marker haplotypes spanning all four SNPs in GPR24 in addition to rs909669 in ADSL with a 5- marker haplotype showing a T4 P-value of 0.0054. | Positive | |
| SZ | rs133073 - rs133070 - rs133069 - rs133068 | MCHR1 | CLUMP T1 P-value = 0.0479, CLUMP T4 P-value = 0.1278 in BPD and SZ, CLUMP T1 P-value = 0.4486, CLUMP T4 P-value = 0.4486 in SZ; Empirical overall P-value = 0.0184 in BPD and SZ, Empirical overall P-value = 0.0135 in SZ | Similarly, comparing controls to the combined group of cases revealed significant associations with 2-, 3-, 4-, and 5-marker haplotypes spanning the SNPs in GPR24 as well as rs909669 in ADSL. | Positive | |
| SZ | rs133068 - D22S279 - rs909669 | MCHR1 ADSL | CLUMP T1 P-value = 0.4823, CLUMP T4 P-value = 0.3996 in BPD and SZ, CLUMP T1 P-value = 0.099, CLUMP T4 P-value = 0.0353 in SZ; Empirical overall P-value = 0.0319 in BPD and SZ, Empirical overall P-value = 0.0015 in SZ | Similarly, comparing controls to the combined group of cases revealed significant associations with 2-, 3-, 4-, and 5-marker haplotypes spanning the SNPs in GPR24 as well as rs909669 in ADSL. | Positive | |
| SZ | rs710193 - rs133073 - rs133070 - rs133069 - rs133068 | ST13 MCHR1 | CLUMP T1 P-value = 0.1722, CLUMP T4 P-value = 0.239 in BPD and SZ, CLUMP T1 P-value = 0.3932, CLUMP T4 P-value = 0.5852 in SZ; Empirical overall P-value = 0.1895 in BPD and SZ, Empirical overall P-value = 0.146 in SZ | Negative | ||
| SZ | rs710193 - rs133073 - rs133070 - rs133069 | ST13 MCHR1 | CLUMP T1 P-value = 0.1755, CLUMP T4 P-value = 0.2417 in BPD and SZ, CLUMP T1 P-value = 0.3957, CLUMP T4 P-value = 0.5862 in SZ; Empirical overall P-value = 0.079 in BPD and SZ, Empirical overall P-value = 0.1069 in SZ | Negative | ||
| SZ | rs710193 - rs133073 - rs133070 | ST13 MCHR1 | CLUMP T1 P-value = 0.1158, CLUMP T4 P-value = 0.1697 in BPD and SZ, CLUMP T1 P-value = 0.3917, CLUMP T4 P-value = 0.5842 in SZ; Empirical overall P-value = 0.0715 in BPD and SZ, Empirical overall P-value = 0.224 in SZ | Negative | ||
| SZ | rs710193 - rs133073 | ST13 MCHR1 | CLUMP T1 P-value = 0.4522, CLUMP T4 P-value = 0.4361 in BPD and SZ, CLUMP T1 P-value = 0.3844, CLUMP T4 P-value = 0.3368 in SZ; Empirical overall P-value = 0.1247 in BPD and SZ, Empirical overall P-value = 0.3269 in SZ | Negative | ||
| SZ | rs1573745 - rs710193 - rs133073 - rs133070 - rs133069 | ST13 MCHR1 | Empirical overall P-value = 0.2604 in BPD and SZ, Empirical overall P-value = 0.1871 in SZ | Negative | ||
| SZ | rs1573745 - rs710193 - rs133073 - rs133070 | ST13 MCHR1 | Empirical overall P-value = 0.1346 in BPD and SZ, Empirical overall P-value = 0.2465 in SZ | Negative | ||
| SZ | rs1573745 - rs710193 - rs133073 | ST13 MCHR1 | Empirical overall P-value = 0.0632 in BPD and SZ, Empirical overall P-value = 0.2105 in SZ | Negative |
| Disease | Variant Name | Related Gene | Type | Statistical Values | Description | Result Category |
|---|---|---|---|---|---|---|
| SZ | D22S279 | microsatellite | CLUMP T1 P-value = 0.0322, CLUMP T4 P-value = 0.0174 for SZ; CLUMP T1 P-value = 0.0705, CLUMP T4 P-value = 0.0268 for BPD and SZ in the Faeroese Sample; Empirical overall P-value = 0.0277 for SZ in the Case-Control Sample From Scotland; Empirical overall P-value = 0.4644 for BPD and SZ in the Case-Control Sample From Scotland | In the Scottish sample only D22S279 showed significant single marker association with SZ | Positive |
| Disease | Gene | Description | Result Category |
|---|---|---|---|
| SZ | MCHR1 | Evidence from both samples suggested GPR24 as a susceptibility gene for both BPD and SZ. | Positive |
| SZ | ADSL | one SNP and haplotypes are associated with SZ in this sample | Positive |
| SZ | ST13 | no significant association was found in this study | Negative |
| Disease | Gene Group | Markers | Statistical Values | Description | Result Category |
|---|---|---|---|---|---|
| SZ | rs133068 - D22S279 - rs909669; rs133069 - rs133068 - D22S279 - rs909669; rs133070 - rs133069 - rs133068 - D22S279 - rs909669; rs909669 - D22S279 - rs133068 - rs133069 - rs133070; rs909669 - D22S279 - rs133068 - rs133069 - rs133070; rs909669 - D22S279 - rs133068 - rs133069 - rs133070 | For markers "rs133068 - D22S279 - rs909669", CLUMP T1 P-value = 0.4823, CLUMP T4 P-value = 0.3996 in BPD and SZ, CLUMP T1 P-value = 0.099, CLUMP T4 P-value = 0.0353 in SZ; Empirical overall P-value = 0.0319 in BPD and SZ, Empirical overall P-value = 0.0015 in SZ; For markers "rs133069 - rs133068 - D22S279 - rs909669", CLUMP T1 P-value = 0.2672, CLUMP T4 P-value = 0.2064 in BPD and SZ, CLUMP T1 P-value = 0.1481, CLUMP T4 P-value = 0.0495 in SZ; Empirical overall P-value = 0.0591 in BPD and SZ, Empirical overall P-value = 0.0012 in SZ; For markers "rs133070 - rs133069 - rs133068 - D22S279 - rs909669", CLUMP T1 P-value = 0.0059, CLUMP T4 P-value = 0.0031 in BPD and SZ, CLUMP T1 P-value = 0.0156, CLUMP T4 P-value = 0.0054 in SZ; Empirical overall P-value = 0.339 in BPD and SZ, Empirical overall P-value = 0.0497 in SZ; For risk haplotype "rs909669 - D22S279 - rs133068 - rs133069 - rs133070(C-7-C-C-A)", CLUMP P-value = 5E-06 in SZ, P-value = 0.0006 in BPD and SZ; For risk haplotype "rs909669 - D22S279 - rs133068 - rs133069 - rs133070(C-6-C-C-A)", CLUMP P-value = 0.5569 in SZ, P-value = 0.3176 in BPD and SZ; For risk haplotype "rs909669 - D22S279 - rs133068 - rs133069 - rs133070(C-6/7-C-C-A)", CLUMP P-value = 0.0002 in SZ, P-value = 7E-05 in BPD and SZ. | Similarly, comparing controls to the combined group of cases revealed significant associations with 2-, 3-, 4-, and 5-marker haplotypes spanning the SNPs in GPR24 as well as rs909669 in ADSL. | Positive | |
| SZ | rs710193 - rs133073; rs710193 - rs133073 - rs133070; rs710193 - rs133073 - rs133070 - rs133069; rs710193 - rs133073 - rs133070 - rs133069 - rs133068; rs1573745 - rs710193 - rs133073; rs1573745 - rs710193 - rs133073 - rs133070; rs1573745 - rs710193 - rs133073 - rs133070 - rs133069 | For markers "rs710193 - rs133073 - rs133070 - rs133069", CLUMP T1 P-value = 0.1755, CLUMP T4 P-value = 0.2417 in BPD and SZ, CLUMP T1 P-value = 0.3957, CLUMP T4 P-value = 0.5862 in SZ; Empirical overall P-value = 0.079 in BPD and SZ, Empirical overall P-value = 0.1069 in SZ. For markers "rs710193 - rs133073 - rs133070 - rs133069 - rs133068", CLUMP T1 P-value = 0.1722, CLUMP T4 P-value = 0.239 in BPD and SZ, CLUMP T1 P-value = 0.3932, CLUMP T4 P-value = 0.5852 in SZ; Empirical overall P-value = 0.1895 in BPD and SZ, Empirical overall P-value = 0.146 in SZ. | Negative |
Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
Acknowledgements
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Last update: March 31, 2016