BDgene

Study Report

Basic Info
Reference
Citation Severinsen, J. E., T. D. Als, et al. (2006). "Association analyses suggest GPR24 as a shared susceptibility gene for bipolar affective disorder and schizophrenia." Am J Med Genet B Neuropsychiatr Genet 141B(5): 524-533.
Disease Type Bipolar Disorder & Schizophrenia
Study Design case-control
Study Type Candidate-gene association study
Sample Size a Faeroese sample of 28 distantly related cases and 44 controls, 4 newly ascertained cases, and a casecontrol sample from Scotland comprising 103 individuals with SZ, 162 with BPD, and 200 controls
SNP/Region/Marker Size 10 variants
Predominant Ethnicity Caucasian
Population Faroese and Scottish

Detail Info

Genetic factors reported by this study for BD
SNPs reported by this study for BD (count: 7)

Haplotypes reported by this study for BD (count: 32)

Other variants reported by this study for BD (count: 1)

Genes reported by this study for BD (count: 3)

Gene-gene interactions reported by this study for BD (count: 2)

Genetic factors reported by this study for SZ and/or MDD
SNPs reported by this study for SZ/MDD
Disease SNP Related Gene(s) Statistical Values Description Result Category
SZ rs133073 MCHR1 CLUMP T1 P-value = 0.0083, CLUMP T4 P-value = 0.0083 for SZ; CLUMP T1 P-value = 0.0546, CLUMP T4 P-value = 0.0546 for BPD and SZ in the Faeroese Sample; Empirical overall P-value = 0.8469 for SZ in the Case-Control Sample From Scotland; Empirical overall P-value = 0.5632 for BPD and SZ in the Case-Control Sample From Scotland The three GPR24 SNPs rs133068, rs133069, and rs133073 showed association with SZ yielding P-values of 0.008-0.02. Positive
SZ rs1573745 ST13 Empirical overall P-value = 0.2879 for SZ in the Case-Control Sample From Scotland; Empirical overall P-value = 0.7989 for BPD and SZ in the Case-Control Sample From Scotland Negative
SZ rs710193 ST13 CLUMP T1 P-value = 0.7065, CLUMP T4 P-value = 0.7065 for SZ; CLUMP T1 P-value = 0.7631, CLUMP T4 P-value = 0.7631 for BPD and SZ in the Faeroese Sample; Empirical overall P-value = 0.2758 for SZ in the Case-Control Sample From Scotland; Empirical overall P-value = 0.2317 for BPD and SZ in the Case-Control Sample From Scotland Negative
SZ rs909669 ADSL CLUMP T1 P-value = 0.1178, CLUMP T4 P-value = 0.1178 for SZ; CLUMP T1 P-value = 0.0036, CLUMP T4 P-value = 0.0036 for BPD and SZ in the Faeroese Sample; Empirical overall P-value = 0.0655 for SZ in the Case-Control Sample From Scotland; Empirical overall P-value = 0.2189 for BPD and SZ in the Case-Control Sample From Scotland In BPD and BPD/SZ combined, single marker association was observed for rs909669 (ADSL) and rs133070 (GPR24) with P-values between 0.0036 and 0.037. Positive
SZ rs133068 MCHR1 GAPDHP37 CLUMP T1 P-value = 0.0197, CLUMP T4 P-value = 0.0197 for SZ; CLUMP T1 P-value = 0.1461, CLUMP T4 P-value = 0.1461 for BPD and SZ in the Faeroese Sample; Empirical overall P-value = 0.8145 for SZ in the Case-Control Sample From Scotland; Empirical overall P-value = 0.8538 for BPD and SZ in the Case-Control Sample From Scotland The three GPR24 SNPs rs133068, rs133069, and rs133073 showed association with SZ yielding P-values of 0.008-0.02. Positive
SZ rs133069 MCHR1 GAPDHP37 CLUMP T1 P-value = 0.01, CLUMP T4 P-value = 0.01 for SZ; CLUMP T1 P-value = 0.074, CLUMP T4 P-value = 0.074 for BPD and SZ in the Faeroese Sample; Empirical overall P-value = 0.8734 for SZ in the Case-Control Sample From Scotland; Empirical overall P-value = 0.7126 for BPD and SZ in the Case-Control Sample From Scotland The three GPR24 SNPs rs133068, rs133069, and rs133073 showed association with SZ yielding P-values of 0.008-0.02. Positive
SZ rs133070 MCHR1 GAPDHP37 CLUMP T1 P-value = 0.2107, CLUMP T4 P-value = 0.2107 for SZ; CLUMP T1 P-value = 0.0116, CLUMP T4 P-value = 0.0116 for BPD and SZ in the Faeroese Sample; Empirical overall P-value = 0.3638 for SZ in the Case-Control Sample From Scotland; Empirical overall P-value = 0.6721 for BPD and SZ in the Case-Control Sample From Scotland In BPD and BPD/SZ combined, single marker association was observed for rs909669 (ADSL) and rs133070 (GPR24) with P-values between 0.0036 and 0.037. Positive

Haplotypes reported by this study for SZ/MDD
Disease Markers Haplotype Related Gene(s)/Region(s) Statistical Values Description Result Category
SZ D22S279 - rs909669 ADSL CLUMP T1 P-value = 0.0805, CLUMP T4 P-value = 0.0501 in BPD and SZ, CLUMP T1 P-value = 0.0447, CLUMP T4 P-value = 0.008 in SZ; Empirical overall P-value = 0.049 in BPD and SZ, Empirical overall P-value = 0.0012 in SZ Similarly, comparing controls to the combined group of cases revealed significant associations with 2-, 3-, 4-, and 5-marker haplotypes spanning the SNPs in GPR24 as well as rs909669 in ADSL. Positive
SZ rs133069 - rs133068 - D22S279 MCHR1 CLUMP T1 P-value = 0.2017, CLUMP T4 P-value = 0.2023 in BPD and SZ, CLUMP T1 P-value = 0.187, CLUMP T4 P-value = 0.1727 in SZ; Empirical overall P-value = 0.3066 in BPD and SZ, Empirical overall P-value = 0.0005 in SZ Similarly, comparing controls to the combined group of cases revealed significant associations with 2-, 3-, 4-, and 5-marker haplotypes spanning the SNPs in GPR24 as well as rs909669 in ADSL. Positive
SZ rs133069 - rs133068 MCHR1 CLUMP T1 P-value = 0.0716, CLUMP T4 P-value = 0.1107 in BPD and SZ, CLUMP T1 P-value = 0.0469, CLUMP T4 P-value = 0.0353 in SZ; Empirical overall P-value = 0.1791 in BPD and SZ, Empirical overall P-value = 0.1238 in SZ Similarly, comparing controls to the combined group of cases revealed significant associations with 2-, 3-, 4-, and 5-marker haplotypes spanning the SNPs in GPR24 as well as rs909669 in ADSL. Positive
SZ rs133069 - rs133070 - rs133073 A-G-C MCHR1 CLUMP P-value = 0.3279 in SZ, P-value = 0.0526 in BPD and SZ; protective haplotype The same specific 2- and 3-marker haplotypes covering rs133069 to rs133073 as seen in BPD showed P-values as low as 0.0183 in the combined sample. Negative
SZ rs133069 - rs133070 A-G MCHR1 CLUMP P-value = 0.3279 in SZ, P-value = 0.0364 in BPD and SZ; protective haplotype The same specific 2- and 3-marker haplotypes covering rs133069 to rs133073 as seen in BPD showed P-values as low as 0.0183 in the combined sample. Positive
SZ D22S279 - rs133068 - rs133069 - rs133070 - rs133073 6-C-C-A-T MCHR1 CLUMP P-value = 1 in SZ, P-value = 0.2166 in BPD and SZ; risk haplotype Negative
SZ D22S279 - rs133068 - rs133069 - rs133070 - rs133073 7-C-C-A-T MCHR1 CLUMP P-value = 0.0013 in SZ, P-value = 0.0139 in BPD and SZ; risk haplotype Positive
SZ rs133068 - D22S279 MCHR1 CLUMP T1 P-value = 0.1818, CLUMP T4 P-value = 0.127 in BPD and SZ, CLUMP T1 P-value = 0.0542, CLUMP T4 P-value = 0.0476 in SZ; Empirical overall P-value = 0.1821 in BPD and SZ, Empirical overall P-value = 0.0054 in SZ Positive
SZ D22S279 - rs133068 - rs133069 - rs133070 - rs133073 6/7-C-C-A-T MCHR1 CLUMP P-value = 0.0013 in SZ, P-value = 0.0005 in BPD and SZ; risk haplotype Positive
SZ rs133073 - rs133070 - rs133069 - rs133068 - D22S279 MCHR1 CLUMP T1 P-value = 0.0063, CLUMP T4 P-value = 0.0023 in BPD and SZ, CLUMP T1 P-value = 0.0432, CLUMP T4 P-value = 0.0375 in SZ; Empirical overall P-value = 0.1747 in BPD and SZ, Empirical overall P-value = 0.0189 in SZ Negative
SZ rs133073 - rs133070 - rs133069 MCHR1 CLUMP T1 P-value = 0.0268, CLUMP T4 P-value = 0.0626 in BPD and SZ, CLUMP T1 P-value = 0.3269, CLUMP T4 P-value = 0.3269 in SZ; Empirical overall P-value = 0.0155 in BPD and SZ, Empirical overall P-value = 0.0148 in SZ Similarly, comparing controls to the combined group of cases revealed significant associations with 2-, 3-, 4-, and 5-marker haplotypes spanning the SNPs in GPR24 as well as rs909669 in ADSL. Positive
SZ rs133070 - rs133073 G-C MCHR1 CLUMP P-value = 0.3286 in SZ, P-value = 0.0183 in BPD and SZ; protective haplotype The same specific 2- and 3-marker haplotypes covering rs133069 to rs133073 as seen in BPD showed P-values as low as 0.0183 in the combined sample. Positive
SZ rs133073 - rs133070 MCHR1 CLUMP T1 P-value = 0.004, CLUMP T4 P-value = 0.0188 in BPD and SZ, CLUMP T1 P-value = 0.5104, CLUMP T4 P-value = 0.5104 in SZ; Empirical overall P-value = 0.0262 in BPD and SZ, Empirical overall P-value = 0.1879 in SZ Similarly, comparing controls to the combined group of cases revealed significant associations with 2-, 3-, 4-, and 5-marker haplotypes spanning the SNPs in GPR24 as well as rs909669 in ADSL. Positive
SZ rs133070 - rs133069 - rs133068 - D22S279 MCHR1 CLUMP T1 P-value = 0.0064, CLUMP T4 P-value = 0.0023 in BPD and SZ, CLUMP T1 P-value = 0.0426, CLUMP T4 P-value = 0.0367 in SZ; Empirical overall P-value = 0.3363 in BPD and SZ, Empirical overall P-value = 0.0053 in SZ Similarly, comparing controls to the combined group of cases revealed significant associations with 2-, 3-, 4-, and 5-marker haplotypes spanning the SNPs in GPR24 as well as rs909669 in ADSL. Positive
SZ rs133070 - rs133073 A-C MCHR1 CLUMP P-value = 1 in SZ, P-value = 0.0234 in BPD and SZ; risk haplotype The same specific 2- and 3-marker haplotypes covering rs133069 to rs133073 as seen in BPD showed P-values as low as 0.0183 in the combined sample. Positive
SZ rs133070 - rs133069 MCHR1 CLUMP T1 P-value = 0.0145, CLUMP T4 P-value = 0.0828 in BPD and SZ, CLUMP T1 P-value = 0.3299, CLUMP T4 P-value = 0.3299 in SZ; Empirical overall P-value = 0.4592 in BPD and SZ, Empirical overall P-value = 0.0618 in SZ Similarly, comparing controls to the combined group of cases revealed significant associations with 2-, 3-, 4-, and 5-marker haplotypes spanning the SNPs in GPR24 as well as rs909669 in ADSL. Positive
SZ rs133070 - rs133069 - rs133068 MCHR1 CLUMP T1 P-value = 0.0525, CLUMP T4 P-value = 0.1831 in BPD and SZ, CLUMP T1 P-value = 0.4456, CLUMP T4 P-value = 0.4456 in SZ; Empirical overall P-value = 0.5945 in BPD and SZ, Empirical overall P-value = 0.0691 in SZ Negative
SZ rs909669 - D22S279 - rs133068 - rs133069 - rs133070 C-6/7-C-C-A MCHR1 ADSL CLUMP P-value = 0.0002 in SZ, P-value = 7E-05 in BPD and SZ; risk haplotype The specific 5-marker haplotype straddling rs909660 to rs133070 as seen inSZ (C7CCA) showed aP-value of 0.0006 in the combined sample, and together with a variant of this haplotype (C6CCA) the haplotypes C-6/7-CCA were over-represented in cases with a frequency of 75% against only 22% in controls. Positive
SZ rs1573745 - rs710193 ST13 Empirical overall P-value = 0.4429 in BPD and SZ, Empirical overall P-value = 0.1394 in SZ Negative
SZ rs909669 - D22S279 - rs133068 - rs133069 - rs133070 C-7-C-C-A MCHR1 ADSL CLUMP P-value = 5E-06 in SZ, P-value = 0.0006 in BPD and SZ; risk haplotype The specific 5-marker haplotype straddling rs909660 to rs133070 as seen inSZ (C7CCA) showed aP-value of 0.0006 in the combined sample, and together with a variant of this haplotype (C6CCA) the haplotypes C-6/7-CCA were over-represented in cases with a frequency of 75% against only 22% in controls. Positive
SZ rs909669 - D22S279 - rs133068 - rs133069 - rs133070 C-6-C-C-A MCHR1 ADSL CLUMP P-value = 0.5569 in SZ, P-value = 0.3176 in BPD and SZ; risk haplotype The specific 5-marker haplotype straddling rs909660 to rs133070 as seen inSZ (C7CCA) showed aP-value of 0.0006 in the combined sample, and together with a variant of this haplotype (C6CCA) the haplotypes C-6/7-CCA were over-represented in cases with a frequency of 75% against only 22% in controls. Negative
SZ rs133069 - rs133068 - D22S279 - rs909669 MCHR1 ADSL CLUMP T1 P-value = 0.2672, CLUMP T4 P-value = 0.2064 in BPD and SZ, CLUMP T1 P-value = 0.1481, CLUMP T4 P-value = 0.0495 in SZ; Empirical overall P-value = 0.0591 in BPD and SZ, Empirical overall P-value = 0.0012 in SZ Similarly, comparing controls to the combined group of cases revealed significant associations with 2-, 3-, 4-, and 5-marker haplotypes spanning the SNPs in GPR24 as well as rs909669 in ADSL. Positive
SZ rs133070 - rs133069 - rs133068 - D22S279 - rs909669 MCHR1 ADSL CLUMP T1 P-value = 0.0059, CLUMP T4 P-value = 0.0031 in BPD and SZ, CLUMP T1 P-value = 0.0156, CLUMP T4 P-value = 0.0054 in SZ; Empirical overall P-value = 0.339 in BPD and SZ, Empirical overall P-value = 0.0497 in SZ When comparing controls to SZ unequal haplotype distribution was observed for 2-, 3-, 4-, and 5-marker haplotypes spanning all four SNPs in GPR24 in addition to rs909669 in ADSL with a 5- marker haplotype showing a T4 P-value of 0.0054. Positive
SZ rs133073 - rs133070 - rs133069 - rs133068 MCHR1 CLUMP T1 P-value = 0.0479, CLUMP T4 P-value = 0.1278 in BPD and SZ, CLUMP T1 P-value = 0.4486, CLUMP T4 P-value = 0.4486 in SZ; Empirical overall P-value = 0.0184 in BPD and SZ, Empirical overall P-value = 0.0135 in SZ Similarly, comparing controls to the combined group of cases revealed significant associations with 2-, 3-, 4-, and 5-marker haplotypes spanning the SNPs in GPR24 as well as rs909669 in ADSL. Positive
SZ rs133068 - D22S279 - rs909669 MCHR1 ADSL CLUMP T1 P-value = 0.4823, CLUMP T4 P-value = 0.3996 in BPD and SZ, CLUMP T1 P-value = 0.099, CLUMP T4 P-value = 0.0353 in SZ; Empirical overall P-value = 0.0319 in BPD and SZ, Empirical overall P-value = 0.0015 in SZ Similarly, comparing controls to the combined group of cases revealed significant associations with 2-, 3-, 4-, and 5-marker haplotypes spanning the SNPs in GPR24 as well as rs909669 in ADSL. Positive
SZ rs710193 - rs133073 - rs133070 - rs133069 - rs133068 ST13 MCHR1 CLUMP T1 P-value = 0.1722, CLUMP T4 P-value = 0.239 in BPD and SZ, CLUMP T1 P-value = 0.3932, CLUMP T4 P-value = 0.5852 in SZ; Empirical overall P-value = 0.1895 in BPD and SZ, Empirical overall P-value = 0.146 in SZ Negative
SZ rs710193 - rs133073 - rs133070 - rs133069 ST13 MCHR1 CLUMP T1 P-value = 0.1755, CLUMP T4 P-value = 0.2417 in BPD and SZ, CLUMP T1 P-value = 0.3957, CLUMP T4 P-value = 0.5862 in SZ; Empirical overall P-value = 0.079 in BPD and SZ, Empirical overall P-value = 0.1069 in SZ Negative
SZ rs710193 - rs133073 - rs133070 ST13 MCHR1 CLUMP T1 P-value = 0.1158, CLUMP T4 P-value = 0.1697 in BPD and SZ, CLUMP T1 P-value = 0.3917, CLUMP T4 P-value = 0.5842 in SZ; Empirical overall P-value = 0.0715 in BPD and SZ, Empirical overall P-value = 0.224 in SZ Negative
SZ rs710193 - rs133073 ST13 MCHR1 CLUMP T1 P-value = 0.4522, CLUMP T4 P-value = 0.4361 in BPD and SZ, CLUMP T1 P-value = 0.3844, CLUMP T4 P-value = 0.3368 in SZ; Empirical overall P-value = 0.1247 in BPD and SZ, Empirical overall P-value = 0.3269 in SZ Negative
SZ rs1573745 - rs710193 - rs133073 - rs133070 - rs133069 ST13 MCHR1 Empirical overall P-value = 0.2604 in BPD and SZ, Empirical overall P-value = 0.1871 in SZ Negative
SZ rs1573745 - rs710193 - rs133073 - rs133070 ST13 MCHR1 Empirical overall P-value = 0.1346 in BPD and SZ, Empirical overall P-value = 0.2465 in SZ Negative
SZ rs1573745 - rs710193 - rs133073 ST13 MCHR1 Empirical overall P-value = 0.0632 in BPD and SZ, Empirical overall P-value = 0.2105 in SZ Negative

Other variants reported by this study for SZ/MDD
Disease Variant Name Related Gene Type Statistical Values Description Result Category
SZ D22S279 microsatellite CLUMP T1 P-value = 0.0322, CLUMP T4 P-value = 0.0174 for SZ; CLUMP T1 P-value = 0.0705, CLUMP T4 P-value = 0.0268 for BPD and SZ in the Faeroese Sample; Empirical overall P-value = 0.0277 for SZ in the Case-Control Sample From Scotland; Empirical overall P-value = 0.4644 for BPD and SZ in the Case-Control Sample From Scotland In the Scottish sample only D22S279 showed significant single marker association with SZ Positive

Genes reported by this study for SZ/MDD
Disease Gene Description Result Category
SZ MCHR1 Evidence from both samples suggested GPR24 as a susceptibility gene for both BPD and SZ. Positive
SZ ADSL one SNP and haplotypes are associated with SZ in this sample Positive
SZ ST13 no significant association was found in this study Negative

Gene-gene interactions reported by this study for SZ/MDD
Disease Gene Group Markers Statistical Values Description Result Category
SZ rs133068 - D22S279 - rs909669; rs133069 - rs133068 - D22S279 - rs909669; rs133070 - rs133069 - rs133068 - D22S279 - rs909669; rs909669 - D22S279 - rs133068 - rs133069 - rs133070; rs909669 - D22S279 - rs133068 - rs133069 - rs133070; rs909669 - D22S279 - rs133068 - rs133069 - rs133070 For markers "rs133068 - D22S279 - rs909669", CLUMP T1 P-value = 0.4823, CLUMP T4 P-value = 0.3996 in BPD and SZ, CLUMP T1 P-value = 0.099, CLUMP T4 P-value = 0.0353 in SZ; Empirical overall P-value = 0.0319 in BPD and SZ, Empirical overall P-value = 0.0015 in SZ; For markers "rs133069 - rs133068 - D22S279 - rs909669", CLUMP T1 P-value = 0.2672, CLUMP T4 P-value = 0.2064 in BPD and SZ, CLUMP T1 P-value = 0.1481, CLUMP T4 P-value = 0.0495 in SZ; Empirical overall P-value = 0.0591 in BPD and SZ, Empirical overall P-value = 0.0012 in SZ; For markers "rs133070 - rs133069 - rs133068 - D22S279 - rs909669", CLUMP T1 P-value = 0.0059, CLUMP T4 P-value = 0.0031 in BPD and SZ, CLUMP T1 P-value = 0.0156, CLUMP T4 P-value = 0.0054 in SZ; Empirical overall P-value = 0.339 in BPD and SZ, Empirical overall P-value = 0.0497 in SZ; For risk haplotype "rs909669 - D22S279 - rs133068 - rs133069 - rs133070(C-7-C-C-A)", CLUMP P-value = 5E-06 in SZ, P-value = 0.0006 in BPD and SZ; For risk haplotype "rs909669 - D22S279 - rs133068 - rs133069 - rs133070(C-6-C-C-A)", CLUMP P-value = 0.5569 in SZ, P-value = 0.3176 in BPD and SZ; For risk haplotype "rs909669 - D22S279 - rs133068 - rs133069 - rs133070(C-6/7-C-C-A)", CLUMP P-value = 0.0002 in SZ, P-value = 7E-05 in BPD and SZ. Similarly, comparing controls to the combined group of cases revealed significant associations with 2-, 3-, 4-, and 5-marker haplotypes spanning the SNPs in GPR24 as well as rs909669 in ADSL. Positive
SZ rs710193 - rs133073; rs710193 - rs133073 - rs133070; rs710193 - rs133073 - rs133070 - rs133069; rs710193 - rs133073 - rs133070 - rs133069 - rs133068; rs1573745 - rs710193 - rs133073; rs1573745 - rs710193 - rs133073 - rs133070; rs1573745 - rs710193 - rs133073 - rs133070 - rs133069 For markers "rs710193 - rs133073 - rs133070 - rs133069", CLUMP T1 P-value = 0.1755, CLUMP T4 P-value = 0.2417 in BPD and SZ, CLUMP T1 P-value = 0.3957, CLUMP T4 P-value = 0.5862 in SZ; Empirical overall P-value = 0.079 in BPD and SZ, Empirical overall P-value = 0.1069 in SZ. For markers "rs710193 - rs133073 - rs133070 - rs133069 - rs133068", CLUMP T1 P-value = 0.1722, CLUMP T4 P-value = 0.239 in BPD and SZ, CLUMP T1 P-value = 0.3932, CLUMP T4 P-value = 0.5852 in SZ; Empirical overall P-value = 0.1895 in BPD and SZ, Empirical overall P-value = 0.146 in SZ. Negative