Gene Report

Basic Info
Approved Symbol ITIH3
Symbol Alias H3P
Approved Name inter-alpha-trypsin inhibitor heavy chain 3
Previous Name inter-alpha (globulin) inhibitor, H3 polypeptide, "inter-alpha (globulin) inhibitor H3"
Name Alias pre-alpha (globulin) inhibitor, H3 polypeptide, "inter-alpha-trypsin inhibitor heavy chain H3"
Location 3p21.1
Position chr3:52794768-52809009, 1
External Links HGNC: 6168
Entrez Gene: 3699
Ensembl: ENSG00000162267
UCSC: uc003dfv.2
No. of Studies 3 (Positive: 3; Negative: 0; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 3)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Cross-Disorder Group of the Psychiatric Genomics Consortium,2013 SNP: rs2535629 Significant association was observed in cross-disorder analysis. Positive Comment on Study
Moskvina, V.,2009 In BD:Smallest P-value per gene=0.0016, Product of P truncation <=0.01=0.0016, Product of P truncation <=0.001=NA. It showed evidence for association with BD. Positive Comment on Study
Kondo, K.,2013 SNP: rs736408 Significant association was observed. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 6)

GO terms by PBA (count: 2)

GO terms by database search (count: 4)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Related other genetic factors
Gene related SNPs (count: 18)

Literature-origin SNPs (count: 2)

LD-proxies (count: 16)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 3)

Overlap with SZ from candidate gene intersection analysis (count: 0)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Overlap with MDD from candidate gene intersection analysis (count: 0)

View in gBrowse

Region: chr3:52794768..52809009 View in gBrowse
View in gBrowse