BDgene

SNP Report

Basic Info
Name rs334558 dbSNP Ensembl
Location chr3:120094435 - 120094435(1)
Variant Alleles A/G
Ancestral Allele G
Minor Allele A
Minor Allele Frequence 0.401358
Functional Annotation upstream_gene_variant.
Consequence to Transcript upstream_gene_variant(ENST00000264235, ENST00000316626, ENST00000469070, ENST00000484076, ENST00000485898)
No. of Studies 3 (Positive: 0; Negative: 3; Trend: 0)
Source Literature
Overlap with SZ? YES
Overlap with MDD? NO

SNP related studies (count: 3)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Lin YF, 2013 C/T Chi square test:genotype,P-value = 0.459,chi square = 1.588;...... Chi square test:genotype,P-value = 0.459,chi square = 1.588;allele,P-value = 0.461,chi square = 0.543 More... No significant association was observed. No significant association was observed. Negative
Tang, H., 2013 Pheterogeneity=0.350, I2=9.9 %; OR=1.0...... Pheterogeneity=0.350, I2=9.9 %; OR=1.06, 95 % CI: 0.93, 1.19 More... On the whole, it exhibited no association in the allelic mod...... On the whole, it exhibited no association in the allelic model between -50C/T (rs334558) and bipolar disorder. No evidence to imply the publication bias was observed by Begg’s funnel plot. And Egger's test further provided statistical support. More... Negative
Chen G., 2014 C/T C vs. T: Asians: OR=1.15, 95%CI=0.95-1.39, Pheterogenei...... C vs. T: Asians: OR=1.15, 95%CI=0.95-1.39, Pheterogeneity-value=0.959, I2=0.0; Caucasians: OR=0.98, 95%CI=0.86-1.11, Pheterogeneity-value=0.208, I2=36.2%; Overall: OR=1.03, 95%CI=0.92-1.15, Pheterogeneity-value=0.393, I2=3.7%. CC vs. TT+TC: OR=1.09, 95%CI=0.82-1.44, Pheterogeneity-value=0.925, I2=0.0; Caucasians: OR=0.97, 95%CI=0.71-1.33, Pheterogeneity-value=0.444, I2=0.0; Overall: OR=1.04, 95%CI=0.84-1.28, Pheterogeneity-value=0.905, I2=0.0. TC+CC vs. TT: Asians: OR=1.48, 95%CI=1.01-2.17, Pheterogeneity-value=0.987, I2=0.0; Caucasians: OR=1.06, 95%CI=0.70-1.59, Pheterogeneity-value=0.052, I2=73.6%; Overall: OR=1.16, 95%CI=0.97-1.39, Pheterogeneity-value=0.202, I2=32.9%. CC vs. TC vs. TT: Asians: OR=1.17, 95%CI=0.96-1.42, Pheterogeneity-value=0.934, I2=0.0; Caucasians: OR=1.03, 95%CI=0.88-1.21, Pheterogeneity-value=0.286, I2=12.0%; Overall: OR= 1.08, 95%CI=0.96-1.22, Pheterogeneity-value=0.705, I2=0.0. More... We identified a total of 6 publications including 1,251 case...... We identified a total of 6 publications including 1,251 cases and 1,804 controls to investigate the effect of GSK3B-50C/T on BD risk, and found no significant association in any genetic models. More... Negative

SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
GSK3B glycogen synthase kinase 3 beta 3q13.3 8(0/8/0)

SNPs in LD with rs334558 (count: 0) View in gBrowse (chr3:120094435..120094435 )

Overlap with SZ from cross-disorder studies (count: 1)
Reference Statistical Result Description Result Category
Tang, H., 2013 Pheterogeneity=0.266, I2=23.2 %; OR=1.12, 95 % CI: 1.01, 1.25 C allele demonstrated more risk than T allele in schizophrenia. No evidence to imply the publication bias was observed by Begg’s funnel plot. And Egger's test further provided statistical support. Positive

Overlap with MDD from cross-disorder studies (count: 0)

Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback Acknowledgements
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Last update: March 31, 2016