BDgene

SNP Report

Basic Info
Name rs133069 dbSNP Ensembl
Location chr22:40678458 - 40678458(1)
Variant Alleles A/C
Ancestral Allele T
Minor Allele A
Minor Allele Frequence 0.339058
Functional Annotation upstream_gene_variant.
Consequence to Transcript upstream_gene_variant(ENST00000249016, ENST00000381433, ENST00000442317, ENST00000465662, ENST00000498400)
No. of Studies 2 (Positive: 0; Negative: 2; Trend: 0)
Source Literature
Overlap with SZ? YES
Overlap with MDD? NO

SNP related studies (count: 2)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Severinsen, J. E., 2006 (a) C/A CLUMP T1 P-value = 0.6815, CLUMP T4 P-value = 0.6815 for BPD...... CLUMP T1 P-value = 0.6815, CLUMP T4 P-value = 0.6815 for BPD; CLUMP T1 P-value = 0.074, CLUMP T4 P-value = 0.074 for BPD and SZ in the Faeroese Sample; Empirical overall P-value = 0.6748 for BPD in the Case-Control Sample From Scotland; Empirical overall P-value = 0.7126 for BPD and SZ in the Case-Control Sample From Scotland More... Negative
Yosifova, A.,2009 A/C Allelic association: P-value = 0.4 Allelic association: P-value = 0.4 No significant association was observed No significant association was observed Negative

SNP related genes (count: 2)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
MCHR1 melanin-concentrating hormone receptor 1 22q13.3 2(1/1/0)
GAPDHP37 glyceraldehyde 3 phosphate dehydrogenase pseudogene 37 22q13.2 Mapped by Literature SNP

SNPs in LD with rs133069 (count: 0) View in gBrowse (chr22:40678458..40678458 )

Overlap with SZ from cross-disorder studies (count: 1)
Reference Statistical Result Description Result Category
Severinsen, J. E., 2006 (a) CLUMP T1 P-value = 0.01, CLUMP T4 P-value = 0.01 for SZ; CLUMP T1 P-value = 0.074, CLUMP T4 P-value = 0.074 for BPD and SZ in the Faeroese Sample; Empirical overall P-value = 0.8734 for SZ in the Case-Control Sample From Scotland; Empirical overall P-value = 0.7126 for BPD and SZ in the Case-Control Sample From Scotland The three GPR24 SNPs rs133068, rs133069, and rs133073 showed association with SZ yielding P-values of 0.008-0.02. Positive

Overlap with MDD from cross-disorder studies (count: 0)