Gene Report

Basic Info
Approved Symbol ADSL
Approved Name adenylosuccinate lyase
Location 22q13.1
Position chr22:40346500-40390463, 1
External Links HGNC: 291
Entrez Gene: 158
Ensembl: ENSG00000239900
UCSC: uc003ayp.4
No. of Studies 2 (Positive: 1; Negative: 1; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Yosifova, A.,2009 SNP: rs909669 No SNP of this gene had significant association with BD in our population. Negative Comment on Study
Severinsen, J. E., 2006 (a) SNP: rs909669
Haplotype: D22S279 - rs909669(), rs133068 - D22S279 - rs909669(), rs133069 - rs133068 - D22S279 - rs909669(), rs133070 - rs133069 - rs133068 - D22S279 - rs909669 (), rs909669 - D22S279 - rs133068 - rs133069 - rs133070(C-7-C-C-A), rs909669 - D22S279 - rs133068 - rs133069 - rs133070(C-6-C-C-A), rs909669 - D22S279 - rs133068 - rs133069 - rs133070(C-6/7-C-C-A)
one SNP and haplotypes are associated with BPD in this sample Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 13)

GO terms by PBA (count: 0)

GO terms by database search (count: 13)

Gene related KEGG pathways (count: 2)

KEGG pathways by PBA (count: 1)

KEGG pathways by database search (count: 1)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors
Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Gene relationship with MDD

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Region: chr22:40346500..40390463 View in gBrowse
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