Study Report

Reference	Hodgkinson, C. A., 2007 PMID: 16936715
Citation	Hodgkinson, C. A., D. Goldman, et al. (2007). "The FEZ1 gene shows no association to schizophrenia in Caucasian or African American populations." Neuropsychopharmacology 32(1): 190-196.
Disease Type	Bipolar Disorder & Schizophrenia
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	The Caucasian sample of 521 individuals was comprised of 212 healthy controls, 178 schizophrenics, 79 bipolar disorder patients, and 58 patients with schizoaffective disorder. The African American sample, totaling 323 individuals, contained 133 healthy controls, 162 diagnosed schizophrenics, and 28 with schizoaffective disorder.
SNP/Region/Marker Size	9 SNPs
Predominant Ethnicity	Caucasian and African American
Population	American

Sample Diagnosis	DSM-IV
Technique	genotyping
Statistical Method	Nonparametric testing for significance values for allelic and genotypic association was performed using a standard X2tests. Haplotype association was evaluated using the more stringent Fisher Exact Test because observed haplotype frequencies sometimes equaled zero. Deviation from Hardy-Weinberg distribution of alleles was determined using the Haploview program. Logistic regression was used to test for interaction between genotypes for each FEZ1 SNP and DISC1 risk/protective haplotypes.
Result Summary	No association to schizophrenia, bipolar disorder or schizoaffective disorder was found for any of the nine markers typed in these populations at the allelic or the genotypic level. Additionally no association was found in either population between specific haplotypes and any of the psychiatric disorders. Variation at the FEZ1 locus does not play a significant role in the etiology of schizophrenia, bipolar disorder or schizoaffective disorder in North American Caucasian or African American populations.