Gene Report

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Basic Info

Approved Symbol	IRF2BP2
Symbol Alias	IRF-2BP2
Approved Name	interferon regulatory factor 2 binding protein 2
Location	1q42.3
Position	chr1:234604269-234609525, -1
External Links	HGNC: 21729 Entrez Gene: 359948 Ensembl: ENSG00000168264 UCSC: uc001hwf.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Bergen, S. E.,2012	SNP: rs271738	No significant association was observed in BD.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 6)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IDA	283

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005737	cytoplasm	cellular component	IEA	322
GO:0006355	regulation of transcription, DNA-templated	biological process	IEA	62
GO:0005654	nucleoplasm	cellular component	IDA	163
GO:0006351	transcription, DNA-templated	biological process	IEA	103
GO:0046872	metal ion binding	molecular function	IEA	115

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs271738	chr1:234527144 - 234527144(1)	downstream_gene_variant	1(0/1/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
1q42	chr1:223900000-236400000	1 (0/1/0)
Chr 1	chr1:0-248956422	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
22688191	No significant association was observed in SZ.	Negative

Gene relationship with MDD

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Region: chr1:234604269..234609525 View in gBrowse