SNP Report

Basic Info

Name	rs821633 dbSNP Ensembl
Location	chr1:232013187 - 232013187(1)
Variant Alleles	T/C
Ancestral Allele	C
Minor Allele	C
Minor Allele Frequence	0.413938
Functional Annotation	downstream_gene_variant; intron_variant.
Consequence to Transcript	downstream_gene_variant(ENST00000422590, ENST00000427560, ENST00000535983); intron_variant(ENST00000366637, ENST00000439617, ENST00000620189, ENST00000622252)
No. of Studies	1 (Positive: 1; Negative: 0; Trend: 0)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	NO

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Chakirova, G.,2011	C/T	C	(CC+CT)>TT: for BD, in the right inferior parietal lobule (P...... (CC+CT)>TT: for BD, in the right inferior parietal lobule (P-value corrected=0.027, z=4.29; kE=330, MNI: x=28, y=-60, z=34) and in the left cingulate gyrus (P-value corrected=0.045, z=4.01; kE=285, MNI: x=-14 y=10, z=36); for healthy controls, in the right cuneus compared with non-carriers (P-value corrected=0.034, z=4.80; kE=308, MNI coordinates: x=12, y=-96, z=8) More...	Significant associations were found . Significant associations were found .	Positive

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
DISC1	disrupted in schizophrenia 1	1q42.1	18(10/7/1)

SNPs in LD with rs821633 (count: 13) View in gBrowse (chr1:232013187..232017285 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Functional Annotation	r²[population]
rs821640	downstream_gene_variant; intron_variant	1.0[CEU]
rs821644	downstream_gene_variant; intron_variant	1.0[CEU]
rs821637	downstream_gene_variant; intron_variant	0.958[CEU]
rs821642	downstream_gene_variant; intron_variant	1.0[CEU]
rs821647	intron_variant	0.957[CEU]
rs821638	downstream_gene_variant; intron_variant	1.0[CEU]
rs821641	downstream_gene_variant; intron_variant	1.0[CEU]
rs821634	downstream_gene_variant; intron_variant	1.0[CEU]
rs821635	downstream_gene_variant; intron_variant	1.0[CEU]
rs821639	downstream_gene_variant; intron_variant	0.955[CEU]
rs821648	intron_variant	1.0[CEU]
rs821645	intron_variant	1.0[CEU]
rs821643	downstream_gene_variant; intron_variant	1.0[CEU]

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Chakirova, G.,2011	(CC+CT)>TT:for SZ, P-value > 0.05	No significant association was observed.	Negative

Overlap with MDD from cross-disorder studies (count: 0)