Gene Report

Basic Info
Approved Symbol ZNF804A
Previous Symbol C2orf10
Approved Name zinc finger protein 804A
Location 2q32.1
Position chr2:184598366-184939492, 1
External Links HGNC: 21711
Entrez Gene: 91752
Ensembl: ENSG00000170396
UCSC: uc002uph.3
No. of Studies 6 (Positive: 3; Negative: 3; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 6)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Schanze, D.,2011 SNP: rs1344706 In a German population, we found none of the GWA risk alleles associated with psychosis. Negative Comment on Study
Sun, Y., 2015 SNP: rs1344706 These findings suggest that ZNF804A might play an important role in common pathogenesis of psychiatric diseases, and its variants are likely involved in regulating the expression of psychosis-related genes, especially the dopamine pathway genes. Further research should focus on the molecular mechanisms by which ZNF804A variants act in psychiatric diseases and related phenotypes. Positive Comment on Study
Zhang, C., 2015 SNP: rs1344706, rs359895 Our findings provided supportive evidence for the involvement of ZNF804A rs1344706 in BD, especially in BD-I. Positive Comment on Study
Xu, W., 2014 SNP: rs17617913 The SNP within or near this gene did not achieve genome-wide significance. Negative Comment on Study
Guella, I., 2013 SNP: rs1344706, rs12476147 No significant association was reported in this study. Negative Comment on Study
Lett, T. A.,2011 SNP: rs1344706 Our fi ndings support previous reports that the ZNF804A gene is associated with BPD. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 1)

GO terms by PBA (count: 0)

GO terms by database search (count: 1)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors
Gene related SNPs (count: 39)

Literature-origin SNPs (count: 4)

LD-proxies (count: 35)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 3)

Overlap with SZ from candidate gene intersection analysis (count: 6)

Gene relationship with MDD

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Region: chr2:184598366..184939492 View in gBrowse
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