Gene Report

Approved Symbol	ZNF804A
Previous Symbol	C2orf10
Approved Name	zinc finger protein 804A
Location	2q32.1
Position	chr2:184598366-184939492, 1
External Links	HGNC: 21711 Entrez Gene: 91752 Ensembl: ENSG00000170396 UCSC: uc002uph.3
No. of Studies	6 (Positive: 3; Negative: 3; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Schanze, D.,2011	SNP: rs1344706	In a German population, we found none of the GWA risk alleles associated with psychosis.	Negative	Comment on Study
Sun, Y., 2015	SNP: rs1344706	These findings suggest that ZNF804A might play an important role in common pathogenesis of psychiatric diseases, and its variants are likely involved in regulating the expression of psychosis-related genes, especially the dopamine pathway genes. Further research should focus on the molecular mechanisms by which ZNF804A variants act in psychiatric diseases and related phenotypes.	Positive	Comment on Study
Zhang, C., 2015	SNP: rs1344706, rs359895	Our findings provided supportive evidence for the involvement of ZNF804A rs1344706 in BD, especially in BD-I.	Positive	Comment on Study
Xu, W., 2014	SNP: rs17617913	The SNP within or near this gene did not achieve genome-wide significance.	Negative	Comment on Study
Guella, I., 2013	SNP: rs1344706, rs12476147	No significant association was reported in this study.	Negative	Comment on Study
Lett, T. A.,2011	SNP: rs1344706	Our fi ndings support previous reports that the ZNF804A gene is associated with BPD.	Positive	Comment on Study

Region: chr2:184598366..184939492 View in gBrowse