Gene Report

Basic Info
Approved Symbol TRANK1
Symbol Alias LBA1, KIAA0342
Approved Name tetratricopeptide repeat and ankyrin repeat containing 1
Name Alias lupus brain antigen 1, "KIAA0342"
Location 3p22.2
Position chr3:36826820-36945057, -1
External Links HGNC: 29011
Entrez Gene: 9881
Ensembl: ENSG00000168016
UCSC: uc003cgj.3
No. of Studies 5 (Positive: 2; Negative: 1; trend: 2)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 5)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Ruderfer, D. M., 2013 SNP: rs9834970 The SNP within or near this gene did not achieve genome-wide significance. Negative Comment on Study
Sklar, P.,2011 SNP: rs6550435 Suggestive association was found. Trend Comment on Study
Green, E. K.,2012 SNP: rs6550435 BD ImmunoChip:P-value = 0.819,OR = 0.988;ImmunoChip, PGC-BD combined data:P-balue = 0.0000454,OR = 1.077 Suggestive association was found. Trend Comment on Study
Chen, D. T.,2011 SNP: rs9834970 The results suggest novel association findings near the gene. Positive Comment on Study
Muhleisen, T. W., 2014 SNP: rs6550435, rs9834970 The fifth best-supported locus in 6 our study (top: rs6550435-G, PGC=2.05*10-8,OR=1.13). Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 3)

GO terms by PBA (count: 0)

GO terms by database search (count: 3)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors
Gene related SNPs (count: 16)

Literature-origin SNPs (count: 3)

LD-proxies (count: 13)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 0)

Gene relationship with MDD

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Region: chr3:36826820..36945057 View in gBrowse
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