Gene Report

ADD to My Gene Set

Basic Info

Approved Symbol	TRANK1
Symbol Alias	LBA1, KIAA0342
Approved Name	tetratricopeptide repeat and ankyrin repeat containing 1
Name Alias	lupus brain antigen 1, "KIAA0342"
Location	3p22.2
Position	chr3:36826820-36945057, -1
External Links	HGNC: 29011 Entrez Gene: 9881 Ensembl: ENSG00000168016 UCSC: uc003cgj.3
No. of Studies	5 (Positive: 2; Negative: 1; trend: 2)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 5)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Ruderfer, D. M., 2013	SNP: rs9834970	The SNP within or near this gene did not achieve genome-wide significance.	Negative	Comment on Study
Sklar, P.,2011	SNP: rs6550435	Suggestive association was found.	Trend	Comment on Study
Green, E. K.,2012	SNP: rs6550435	BD ImmunoChip:P-value = 0.819,OR = 0.988;ImmunoChip, PGC-BD combined data:P-balue = 0.0000454,OR = 1.077 Suggestive association was found.	Trend	Comment on Study
Chen, D. T.,2011	SNP: rs9834970	The results suggest novel association findings near the gene.	Positive	Comment on Study
Muhleisen, T. W., 2014	SNP: rs6550435, rs9834970	The fifth best-supported locus in 6 our study (top: rs6550435-G, PGC=2.05*10-8,OR=1.13).	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 3)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0008152	metabolic process	biological process	IEA	50
GO:0005524	ATP binding	molecular function	IEA	118
GO:0016787	hydrolase activity	molecular function	IEA	1

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 16)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs6550435	chr3:36822998 - 36822998(1)	downstream_gene_variant; upstream_gene_variant	3(1/0/2)
rs13072940	chr3:36801132 - 36801132(1)		1(1/0/0)
rs9834970	chr3:36814539 - 36814539(1)	downstream_gene_variant	6(3/1/2)

rs_ID	Location	Functional Annotation
rs12637912	chr3:36830403 - 36830403(1)	intron_variant
rs7652637	chr3:36830016 - 36830016(1)	intron_variant; upstream_gene_variant
rs9882911	chr3:36843901 - 36843901(1)	intron_variant; non_coding_transcript_variant
rs9821223	chr3:36841878 - 36841878(1)	downstream_gene_variant; intron_variant
rs17807744	chr3:36852557 - 36852557(1)	intron_variant; upstream_gene_variant
rs4678910	chr3:36846482 - 36846482(1)	intron_variant; non_coding_transcript_variant
rs9811916	chr3:36836595 - 36836595(1)	intron_variant
rs3732386	chr3:36830502 - 36830502(1)	intron_variant
rs4234258	chr3:36837479 - 36837479(1)	intron_variant
rs4678909	chr3:36837072 - 36837072(1)	intron_variant
rs11706780	chr3:36854744 - 36854744(1)	intron_variant; upstream_gene_variant
rs11129735	chr3:36828739 - 36828739(1)	intron_variant; upstream_gene_variant
rs4789	chr3:36827948 - 36827948(1)	3_prime_UTR_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 3	chr3:0-198295559	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
24280982	The SNP within or near this gene did not achieve genome-wide significance.	Negative

Gene relationship with MDD

View in gBrowse

Region: chr3:36826820..36945057 View in gBrowse