SNP Report

Basic Info

Name	rs3749034 dbSNP Ensembl
Location	chr2:170816965 - 170816965(1)
Variant Alleles	G/A
Ancestral Allele	G
Minor Allele	A
Minor Allele Frequence	0.175519
Functional Annotation	5_prime_UTR_variant; intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant.
Consequence to Transcript	5_prime_UTR_variant(ENST00000344257, ENST00000358196, ENST00000375272, ENST00000445006, ENST00000625689); intron_variant(ENST00000454603); non_coding_transcript_exon_variant(ENST00000418106, ENST00000451730, ENST00000455988); non_coding_transcript_variant(ENST00000418106, ENST00000451730, ENST00000455988); upstream_gene_variant(ENST00000414527, ENST00000429023, ENST00000455008, ENST00000456864, ENST00000485013, ENST00000493875)
No. of Studies	2 (Positive: 0; Negative: 2; Trend: 0)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	NO

SNP related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Yosifova, A.,2009	A/G		Allelic association: P-value = 0.37 Allelic association: P-value = 0.37	No significant association was observed No significant association was observed	Negative
Lundorf, M. D.,2005	G/A		Fisher's exact test: for BPAD, in Danish sample set, P-value...... Fisher's exact test: for BPAD, in Danish sample set, P-value(allele)=0.068, P-value(genotype)=0.096; in Scottish sample set, P-value(allele)=0.74, P-value(genotype)=0.91 More...	No significant association was observed. No significant association was observed.	Negative

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
GAD1	glutamate decarboxylase 1 (brain, 67kDa)	2q31	2(1/1/0)

SNPs in LD with rs3749034 (count: 3) View in gBrowse (chr2:170805829..170826597 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Functional Annotation	r²[population]
rs1477061	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant	0.82[CEU]
rs3762555	downstream_gene_variant; intron_variant; upstream_gene_variant	0.93[CEU]
rs6736129		0.946[TSI]

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Lundorf, M. D.,2005	Fisher's exact test:for SZ, in Scottish sample set, P-value(allele)=0.61, P-value(genotype)=0.071	No significant association was observed.	Negative

Overlap with MDD from cross-disorder studies (count: 0)