SNP Report

Basic Info

Name	rs6295 dbSNP Ensembl
Location	chr5:63962738 - 63962738(1)
Variant Alleles	C/G
Ancestral Allele	G
Minor Allele	C
Minor Allele Frequence	0.453275
Functional Annotation	intron_variant; non_coding_transcript_variant; upstream_gene_variant.
Consequence to Transcript	intron_variant(ENST00000502882); non_coding_transcript_variant(ENST00000502882); upstream_gene_variant(ENST00000323865, ENST00000506598)
No. of Studies	2 (Positive: 2; Negative: 0; Trend: 0)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	YES

SNP related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Kishi, T.,2012(a)			Meta analysis:BP: P (dominant model) = 0.003 Meta analysis:BP: P (dominant model) = 0.003	Significant association was found. Significant association was found.	Positive
Kishi, T.,2011(b)	C>G		For BD, chi-square tests: genotype, P-value = 0.0116, correc...... For BD, chi-square tests: genotype, P-value = 0.0116, corrected P-value = 0.139; allele, P-value = 0.00337, corrected P-value = 0.0404.Meta analysis: fixed model: pooled OR=0.794, 95% CI=0.641-0.983, P(Z)=0.0344).No publication bias was found (t=0.656, p=0.536). More...	Significant associations were found in both allele and genot...... Significant associations were found in both allele and genotype association. More...	Positive

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
HTR1A	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled	5q11.2-q13	3(2/1/0)

SNPs in LD with rs6295 (count: 0) View in gBrowse (chr5:63962738..63962738 )

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Kishi, T.,2011(b)	For SZ, chi-square tests:genotype, P-value = 0.12;allele, P-value = 0.146;meta analysis:random model:pooled OR=0.793, 95% CI=0.387-1.623, P(Z)=0.526	No significant association was observed.	Negative

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Kishi, T.,2012(a)	Meta analysis:MDD: P (allele model) = 0.006, P (recessive model) = 0.01	Significant association was found.	Positive