SNP Report

Basic Info

Name	rs3784735 dbSNP Ensembl
Location	chr15:92432099 - 92432099(1)
Variant Alleles	A/C
Ancestral Allele	A
Minor Allele	C
Minor Allele Frequence	0.466054
Functional Annotation	intron_variant; upstream_gene_variant.
Consequence to Transcript	intron_variant(ENST00000268164, ENST00000539113, ENST00000555434); upstream_gene_variant(ENST00000556382)
No. of Studies	1 (Positive: 1; Negative: 0; Trend: 0)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	NO

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
McAuley, E. Z., 2012	C/A		P-value = 0.032, Empirical P-value = 0.034, OR (95% CI)=0.73...... P-value = 0.032, Empirical P-value = 0.034, OR (95% CI)=0.73 (0.54-0.97) in the Australian bipolar disorder cohort More...	Nominally significant association (P < 0.05) was found with ...... Nominally significant association (P < 0.05) was found with 18 SNPs. Association with 14 of these SNPs held true when empirical P values were obtained through 10, 000 replicate permutations. More...	Positive

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
ST8SIA2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	15q26	2(2/0/0)

SNPs in LD with rs3784735 (count: 30) View in gBrowse (chr15:92411086..92439419 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 30)

rs_ID	Functional Annotation	r²[population]
rs3825986	intron_variant; upstream_gene_variant	0.885[CEU]; 0.801[TSI]
rs8026158	intron_variant; upstream_gene_variant	0.811[CEU]
rs12438164	intron_variant; non_coding_transcript_variant	0.847[CEU]; 0.802[TSI]
rs2892364	downstream_gene_variant; intron_variant	0.922[CEU]; 0.934[TSI]
rs3848155	intron_variant; upstream_gene_variant	0.924[CEU]
rs3784740	intron_variant; upstream_gene_variant	0.845[CEU]
rs4777979	downstream_gene_variant; intron_variant; non_coding_transcript_variant	0.887[CEU]; 0.89[TSI]
rs7177050	intron_variant; non_coding_transcript_variant	0.885[CEU]
rs4777712	intron_variant; non_coding_transcript_variant	0.844[CEU]
rs1869777	intron_variant; upstream_gene_variant	0.924[CEU]; 0.934[TSI]
rs4777977	intron_variant; upstream_gene_variant	0.885[CEU]; 0.8[TSI]
rs3887775	intron_variant	0.888[CEU]
rs3848153	downstream_gene_variant; intron_variant; upstream_gene_variant	0.887[CEU]
rs3848152	downstream_gene_variant; intron_variant; upstream_gene_variant	0.848[CEU]
rs3902203	intron_variant; upstream_gene_variant	0.924[CEU]; 0.934[TSI]
rs11074071	intron_variant; non_coding_transcript_variant	0.878[CEU]
rs9920408	intron_variant; non_coding_transcript_variant	0.844[CEU]
rs4777981	intron_variant; non_coding_transcript_variant	0.847[CEU]; 0.802[TSI]
rs10162611	intron_variant	0.849[CEU]
rs3784736	intron_variant; upstream_gene_variant	0.961[CEU]
rs17521726	intron_variant; non_coding_transcript_variant	0.847[CEU]; 0.802[TSI]
rs17521754	intron_variant; non_coding_transcript_variant	0.844[CEU]
rs3825985	intron_variant	0.961[CEU]; 0.955[TSI]
rs11635453	downstream_gene_variant; intron_variant	0.848[CEU]
rs4777711	intron_variant; non_coding_transcript_variant	0.847[CEU]
rs3931230	intron_variant; upstream_gene_variant	0.961[CEU]; 0.932[TSI]
rs3784738	downstream_gene_variant; intron_variant; upstream_gene_variant	0.844[TSI]
rs11632521	intron_variant; non_coding_transcript_variant	0.957[CEU]
rs17521740	intron_variant; non_coding_transcript_variant	0.844[CEU]
rs4777982	intron_variant; non_coding_transcript_variant	0.811[CEU]

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
McAuley, E. Z., 2012	P-value > 0.075	Single SNP analysis did not yield significant evidence for association.	Negative

Overlap with MDD from cross-disorder studies (count: 0)