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Gene Report
| Basic information | Related studies | Functional annotation | Related other genetic factors | Overlap with SZ and MDD | ADD to My Gene Set | Comment on Gene | View All Comments on Gene |
| Approved Symbol | GFI1B |
|---|---|
| Approved Name | growth factor independent 1B transcription repressor |
| Previous Name | growth factor independent 1B (potential regulator of CDKN1A, translocated in CML) |
| Location | 9q34.13 |
| Position | chr9:132944000-132991687, 1 |
| External Links |
HGNC: 4238 Entrez Gene: 8328 Ensembl: ENSG00000165702 UCSC: uc004ccg.3 |
| No. of Studies | 1 (Positive: 0; Negative: 1; trend: 0) |
| Overlap with SZ? | YES |
| Overlap with MDD? | NO |
Gene related studies (count: 1)
| Reference | Tested Markers | Statistical Values/Author Comments | Result Category | Comment on Study |
|---|---|---|---|---|
| Bergen, S. E.,2012 | SNP: rs3011267 | No significant association was observed in BD. | Negative | Comment on Study |
Gene functional annotation
Gene related GO terms (count: 13)
GO terms by PBA (count: 2)
| ID | Name | Type | Evidence[PMID] | No. of Genes in BDgene |
|---|---|---|---|---|
| GO:0003677 | DNA binding | molecular function | IEA | 83 |
| GO:0005634 | nucleus | cellular component | IDA[12874834] | 283 |
GO terms by database search (count: 11)
| ID | Name | Type | Evidence[PMID] | No. of Genes in BDgene |
|---|---|---|---|---|
| GO:0008283 | cell proliferation | biological process | TAS[9566867] | 37 |
| GO:0016363 | nuclear matrix | cellular component | IDA[12874834] | 7 |
| GO:0051569 | regulation of histone H3-K4 methylation | biological process | IEA | 1 |
| GO:0001085 | RNA polymerase II transcription factor binding | molecular function | IPI[15920471] | 6 |
| GO:0030097 | hemopoiesis | biological process | IEA | 7 |
| GO:0006366 | transcription from RNA polymerase II promoter | biological process | TAS[9566867] | 31 |
| GO:0046872 | metal ion binding | molecular function | IEA | 115 |
| GO:0005667 | transcription factor complex | cellular component | IDA[15920471] | 18 |
| GO:0016568 | chromatin modification | biological process | IEA | 5 |
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | biological process | TAS[9566867] | 62 |
| GO:0005515 | protein binding | molecular function | IPI[12874834] | 563 |
Gene related KEGG pathways (count: 0)
Gene related BioCarta pathways (count: 0)
Gene related interactors from protein-protein interactions data in HPRD (count: 68)
| Gene | Interactor | Interactor in BDgene? | Experiment Type | PMID |
|---|---|---|---|---|
| GFI1B | BRCA1 | NO | yeast 2-hybrid | 16713569 |
| GFI1B | HGS | NO | yeast 2-hybrid | 16713569 |
| GFI1B | AGPAT6 | NO | yeast 2-hybrid | 16713569 |
| GFI1B | ZNRF3 | NO | yeast 2-hybrid | 16713569 |
| GFI1B | RCHY1 | NO | yeast 2-hybrid | 16713569 |
| GFI1B | ZNRD1 | NO | yeast 2-hybrid | 16713569 |
| GFI1B | KIF17 | NO | yeast 2-hybrid | 16713569 |
| GFI1B | HSPG2 | NO | yeast 2-hybrid | 16713569 |
| GFI1B | MON1A | NO | yeast 2-hybrid | 16713569 |
| GFI1B | IFFO1 | NO | yeast 2-hybrid | 16713569 |
| GFI1B | CENPB | YES | yeast 2-hybrid | 16713569 |
| GFI1B | HNRNPK | NO | yeast 2-hybrid | 16713569 |
| GFI1B | COPS5 | NO | yeast 2-hybrid | 16713569 |
| GFI1B | PSMA3 | NO | yeast 2-hybrid | 16713569 |
| GFI1B | MEGF8 | NO | yeast 2-hybrid | 16713569 |
| GFI1B | VSNL1 | NO | yeast 2-hybrid | 16713569 |
| GFI1B | FBLN5 | NO | yeast 2-hybrid | 16713569 |
| GFI1B | LTBP4 | NO | yeast 2-hybrid | 16713569 |
| GFI1B | RNF31 | NO | yeast 2-hybrid | 16713569 |
| GFI1B | MATR3 | NO | yeast 2-hybrid | 16713569 |
| GFI1B | CCDC136 | NO | yeast 2-hybrid | 16713569 |
| GFI1B | BECN1 | NO | yeast 2-hybrid | 16713569 |
| GFI1B | LZTS2 | NO | yeast 2-hybrid | 16713569 |
| GFI1B | GRN | YES | yeast 2-hybrid | 16713569 |
| GFI1B | KALRN | NO | yeast 2-hybrid | 16713569 |
| GFI1B | NELF | NO | yeast 2-hybrid | 16713569 |
| GFI1B | EFEMP2 | NO | yeast 2-hybrid | 16713569 |
| GFI1B | TRIM27 | NO | yeast 2-hybrid | 16713569 |
| GFI1B | PHC2 | NO | yeast 2-hybrid | 16713569 |
| GFI1B | JAG2 | NO | yeast 2-hybrid | 16713569 |
| GFI1B | RUNDC3A | YES | yeast 2-hybrid | 16713569 |
| GFI1B | ANKS3 | NO | yeast 2-hybrid | 16713569 |
| GFI1B | USHBP1 | NO | yeast 2-hybrid | 16713569 |
| GFI1B | LAMB1 | YES | yeast 2-hybrid | 16713569 |
| GFI1B | AES | NO | yeast 2-hybrid | 16713569 |
| GFI1B | TRIP6 | NO | yeast 2-hybrid | 16713569 |
| GFI1B | MYH14 | YES | yeast 2-hybrid | 16713569 |
| GFI1B | TENC1 | NO | yeast 2-hybrid | 16713569 |
| GFI1B | EFEMP1 | NO | yeast 2-hybrid | 16713569 |
| GFI1B | AGRN | NO | yeast 2-hybrid | 16713569 |
| GFI1B | RAB11FIP4 | NO | yeast 2-hybrid | 16713569 |
| GFI1B | PDE4DIP | NO | yeast 2-hybrid | 16713569 |
| GFI1B | TMF1 | NO | yeast 2-hybrid | 16713569 |
| GFI1B | HECW1 | NO | yeast 2-hybrid | 16713569 |
| GFI1B | NOTCH1 | NO | yeast 2-hybrid | 16713569 |
| GFI1B | BEGAIN | NO | yeast 2-hybrid | 16713569 |
| GFI1B | CCDC85B | NO | yeast 2-hybrid | 16713569 |
| GFI1B | NELL1 | NO | yeast 2-hybrid | 16713569 |
| GFI1B | TSPYL2 | NO | yeast 2-hybrid | 16713569 |
| GFI1B | MEGF6 | NO | yeast 2-hybrid | 16713569 |
| GFI1B | PICK1 | YES | yeast 2-hybrid | 16713569 |
| GFI1B | PDZD4 | NO | yeast 2-hybrid | 16713569 |
| GFI1B | FBLN1 | NO | yeast 2-hybrid | 16713569 |
| GFI1B | BEND5 | NO | yeast 2-hybrid | 16713569 |
| GFI1B | JUB | NO | yeast 2-hybrid | 16713569 |
| GFI1B | NELL2 | NO | yeast 2-hybrid | 16713569 |
| GFI1B | DNAJA3 | YES | yeast 2-hybrid | 16713569 |
| GFI1B | TXNDC11 | NO | yeast 2-hybrid | 16713569 |
| GFI1B | EGFL7 | NO | yeast 2-hybrid | 16713569 |
| GFI1B | MID2 | NO | yeast 2-hybrid | 16713569 |
| GFI1B | ACTN1 | NO | yeast 2-hybrid | 16713569 |
| GFI1B | ATXN2 | YES | yeast 2-hybrid | 16713569 |
| GFI1B | RINT1 | NO | yeast 2-hybrid | 16713569 |
| GFI1B | TRAF1 | NO | yeast 2-hybrid | 16713569 |
| GFI1B | C20orf12 | NO | yeast 2-hybrid | 16713569 |
| GFI1B | TAF1 | NO | yeast 2-hybrid | 16713569 |
| GFI1B | DTNA | NO | yeast 2-hybrid | 16713569 |
| GFI1B | CENPJ | NO | yeast 2-hybrid | 16713569 |
Related other genetic factors
Gene related SNPs (count: 3)
Literature-origin SNPs (count: 2)
| rs_ID | Location | Functional Annotation | No. of Studies (Positive/Negative/Trend)  |
|---|---|---|---|
| rs3011267 | chr9:133005806 - 133005806(1) | 1(0/1/0) | |
| rs2905072 | chr9:132969648 - 132969648(1) | intron_variant | 1(0/0/1) |
LD-proxies (count: 1)
| rs_ID | Literature-origin SNPs with LD | Location | Functional Annotation |
|---|---|---|---|
| rs3011259 | chr9:132970228 - 132970228(1) | intron_variant |
Gene related CNVs (count: 0)
Gene related other variants (count: 0)
Gene related regions (count: 3)
| Region Name | Position | No. of Studies (Positive/Negative/Trend) |
|---|---|---|
| Chr 9 | chr9:0-138394717 | 3 (0/3/0) |
| 9q33.3-34.3 | chr9:123100000-138394717 | 1 (0/1/0) |
| 9q34 | chr9:127500000-138394717 | 1 (0/0/1) |
Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ
Overlap with SZ from cross-disorder studies (count: 1)
| Reference | Description | Result Category |
|---|---|---|
| 22688191 | No significant association was observed in SZ. | Negative |
Overlap with SZ from candidate gene intersection analysis (count: 0)
Gene relationship with MDD
View in gBrowse
Region: chr9:132944000..132991687 View in gBrowse
Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
Acknowledgements
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Last update: March 31, 2016