BDgene

SNP Report

Basic Info
Name rs951266 dbSNP Ensembl
Location chr15:78586199 - 78586199(1)
Variant Alleles G/A
Ancestral Allele G
Minor Allele A
Minor Allele Frequence 0.163139
Functional Annotation downstream_gene_variant; intron_variant; upstream_gene_variant.
Consequence to Transcript downstream_gene_variant(ENST00000567141); intron_variant(ENST00000299565, ENST00000394802, ENST00000559554); upstream_gene_variant(ENST00000559576)
No. of Studies 2 (Positive: 1; Negative: 1; Trend: 0)
Source Literature
Overlap with SZ? YES
Overlap with MDD? NO

SNP related studies (count: 2)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Shi, J., 2007 A/G TDT P-value = 0.36 of Allelic Association With Bipolar Disor...... TDT P-value = 0.36 of Allelic Association With Bipolar Disorder in the Combined Sample More... Negative
Jackson, K. J., 2013 C/T P-value=0.02, OR=1.1, 95% CI=(1.02-1.18) in BD; P-value=0.00...... P-value=0.02, OR=1.1, 95% CI=(1.02-1.18) in BD; P-value=0.009, OR=1.07, 95% CI=(1.02-1.13) in SZD + BD More... Meta analysis of the bipolar studies showed association with...... Meta analysis of the bipolar studies showed association with rs951266 and risk for bipolar disorder. When the schizophrenia and bipolar disorder results were combined, four markers, rs951266, rs16969968, rs8040868, and rs17487223, were significantly associated with risk for schizophrenia and bipolar disorder. More... Positive

SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) 15q24 3(2/1/0)

SNPs in LD with rs951266 (count: 21) View in gBrowse (chr15:78437971..78606381 )
The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 21)


Overlap with SZ from cross-disorder studies (count: 1)
Reference Statistical Result Description Result Category
Jackson, K. J., 2013 P-value=0.15, OR=1.05, 95% CI=(1.02-1.18) in SZD; P-value=0.009, OR=1.07, 95% CI=(1.02-1.13) in SZD + BD; P-value=0.017, OR=1.19, 95% CI=(1.03-1.37) in SZD with the presence of negative symptoms of schizophrenia When the schizophrenia and bipolar disorder results were combined, four markers, rs951266, rs16969968, rs8040868, and rs17487223, were significantly associated with risk for schizophrenia and bipolar disorder. A meta-analysis of the results revealed a significant association with the variants rs951266, rs1051730, rs8040868, and rs1748722, and the presence of negative symptoms. Positive

Overlap with MDD from cross-disorder studies (count: 0)

Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback Acknowledgements
To view this website normally, please make sure to allow Flash to run from the local filesystem in the security settings panel.
Last update: March 31, 2016