SNP Report

Basic Info

Name	rs2297488 dbSNP Ensembl
Location	chr10:62815485 - 62815485(1)
Variant Alleles	G/A
Ancestral Allele	G
Minor Allele	A
Minor Allele Frequence	0.0892572
Functional Annotation	intron_variant; non_coding_transcript_variant.
Consequence to Transcript	intron_variant(ENST00000242480, ENST00000411732, ENST00000439032, ENST00000493899, ENST00000637191, LRG_239t1); non_coding_transcript_variant(ENST00000493899)
No. of Studies	3 (Positive: 1; Negative: 2; Trend: 0)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	NO

SNP related studies (count: 3)

Reference	Allele Change	Statistical Values	Author Comments	Result Category
Balan S, 2013	A/G	Pearson's Ï‡2 test, genotypic P-value=0.62, Fisher's exact t...... Pearson's Ï‡2 test, genotypic P-value=0.62, Fisher's exact test, allelic P-value=0.58, OR=0.94, 95% CI=0.77-1.15; meta-analysis, overall effect: Z=1.19, P-value=0.23 for fixed model, Z=1.02, P-value=0.31 for random model More...	There were no significant difference in genotype and allele ...... There were no significant difference in genotype and allele frequencies of EGR2 SNPs between bipolar disorder patients and controls. Themeta-analysis of the two studies also showed no significant association in both random-effects and fixed-effects model, and a high heterogeneity among the studies was observed with I2 values ranging from 47% to 78%. More...	Negative
Gallitano, A. L.,2012		Association analysis: FBAT, P-value > 0.05 Association analysis: FBAT, P-value > 0.05	No significant association was observed in BD. No significant association was observed in BD.	Negative
Kim, S. H.,2011	G/A	For BD, chi-square tests: allele, OR=1.527, X²=6....... For BD, chi-square tests: allele, OR=1.527, X²=6.4911, P-value = 0.0103, P-value(permutation)=0.046; Fisher's exact test, genotype, X²=7.4584, P-value = 0.024 More...	Significant associations were found in both allele and genot...... Significant associations were found in both allele and genotype association. More...	Positive

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
EGR2	early growth response 2	10q21.1	3(1/2/0)

SNPs in LD with rs2297488 (count: 0) View in gBrowse (chr10:62815485..62815485 )

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Kim, S. H.,2011	For SZ, chi-square tests:allele, OR=1.114, X²=0.3127, P-value = 0.576, P-value(permutation)=0.5592;Fisher's exact test, genotype, X²=2.9107, P-value = 0.2333	No significant association was observed.	Negative

Overlap with MDD from cross-disorder studies (count: 0)