SNP Report

Basic Info

Name	rs1051730 dbSNP Ensembl
Location	chr15:78601997 - 78601997(1)
Variant Alleles	G/A
Ancestral Allele	G
Minor Allele	A
Minor Allele Frequence	0.168131
Functional Annotation	NMD_transcript_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; synonymous_variant; upstream_gene_variant.
Consequence to Transcript	NMD_transcript_variant(ENST00000559658); non_coding_transcript_exon_variant(ENST00000558903); non_coding_transcript_variant(ENST00000558903); synonymous_variant(ENST00000326828, ENST00000348639, ENST00000559658); upstream_gene_variant(ENST00000624172)
No. of Studies	2 (Positive: 0; Negative: 2; Trend: 0)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	NO

SNP related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Jackson, K. J., 2013	G/A		P-value=0.24, OR=1.05, 95% CI=(0.97-1.13) in BD; P-value=0.0...... P-value=0.24, OR=1.05, 95% CI=(0.97-1.13) in BD; P-value=0.08, OR=1.05, 95% CI=(0.99-1.1) in SZD + BD More...	No significant association was found. No significant association was found.	Negative
Hartz, S. M.,2011			X² test: for nicotine dependence with and without...... X² test: for nicotine dependence with and without bipolar disorder, allele P-value = 0.99; logistic regression: for BD case-control, P-value = 0.27, OR=0.92, 95% CI=0.8-1.1, when smoking as a covariate, P-value = 0.37, OR=0.93, for non-smokers only, P-value = 0.21, OR=0.87 More...	No significant association was observed. No significant association was observed.	Negative

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
CHRNA3	cholinergic receptor, nicotinic, alpha 3 (neuronal)	15q24	3(1/2/0)

SNPs in LD with rs1051730 (count: 0) View in gBrowse (chr15:78601997..78601997 )

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Jackson, K. J., 2013	P-value=0.19, OR=1.05, 95% CI=(0.97-1.13) in SZD; P-value=0.08, OR=1.05, 95% CI=(0.99-1.1) in SZD + BD; P-value=0.019, OR=1.19, 95% CI=(1.03-1.37) in SZD with the presence of negative symptoms of schizophrenia	A meta-analysis of the results revealed a significant association with the variants rs951266, rs1051730, rs8040868, and rs1748722, and the presence of negative symptoms.	Positive

Overlap with MDD from cross-disorder studies (count: 0)