SNP Report

Basic Info

Name	rs6903874 dbSNP Ensembl
Location	chr6:132575771 - 132575771(1)
Variant Alleles	T/C
Ancestral Allele	T
Minor Allele	C
Minor Allele Frequence	0.225839
Functional Annotation	downstream_gene_variant.
Consequence to Transcript	downstream_gene_variant(ENST00000275198)
No. of Studies	3 (Positive: 1; Negative: 2; Trend: 0)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	YES

SNP related studies (count: 3)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Liu, C., 2007	A/G		TDT P-value = 0.33 in CNG+NIMH waves I+2, TDT P-value = 0.27...... TDT P-value = 0.33 in CNG+NIMH waves I+2, TDT P-value = 0.27 in NIMH waves 3+4 + CHIP, TDT P-value = 0.15 in Entire sample More...		Negative
Venken, T., 2006			P-value > 0.05 P-value > 0.05	The analysis revealed no significant associations between bi...... The analysis revealed no significant associations between bipolar disorder patients and control individuals. More...	Negative
Pae, C. U., 2008	T/C	C	Allele frequency (BID vs.control) 0.15 vs. 0.09; X^{2 Allele frequency (BID vs.control) 0.15 vs. 0.09; X²(df=1)= 8.08, P-value = 0.005 More...}	The minor allele (C) of SNP rs6903874 was significantly over...... The minor allele (C) of SNP rs6903874 was significantly over-represented among the patients with BID compared to controls. The significant association of rs6903874 with BID was not observed in the bipolar patients who manifested psychotic features, when analyzed alone vs. controls. More...	Positive

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
TAAR6	trace amine associated receptor 6	6q23.1	5(4/1/0)

SNPs in LD with rs6903874 (count: 5) View in gBrowse (chr6:132575771..132579552 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Functional Annotation	r²[population]
rs6924201	downstream_gene_variant	1.0[CEU]; 1.0[CHB]; 1.0[JPT]
rs6935920		1.0[CEU]; 1.0[CHB]; 1.0[JPT]
rs6569812		0.882[CEU]; 1.0[CHB]; 1.0[JPT]
rs6921461		1.0[CEU]; 1.0[CHB]; 1.0[JPT]
rs6941913		1.0[CEU]; 1.0[CHB]; 1.0[JPT]

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Pae, C. U., 2008	Allele frequency (SZ vs.control) 0.14 vs. 0.09; X²(df=1)= 6.28, P-value = 0.012	The minor allele (C) of SNP rs6903874 was significantly over-represented among the patients with schizophrenia compared to controls.	Positive

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Pae, C. U., 2008		The significant association of rs6903874 with BID was not observed in the overall groups of patients with MDD nor in the patients with psychotic MDD vs. controls.	Negative