Gene Report

Basic Info
Approved Symbol GRN
Symbol Alias PCDGF, PGRN, CLN11
Approved Name granulin
Name Alias progranulin
Location 17q21.32
Position chr17:44345086-44353102, 1
External Links HGNC: 4601
Entrez Gene: 2896
Ensembl: ENSG00000030582
UCSC: uc002igp.1
No. of Studies 2 (Positive: 2; Negative: 0; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Galimberti, D.,2012 SNP: rs2879096, rs3785817, rs4792938, rs5848, rs9897526 In conclusion, we demonstrated that GRN variability contributes to schizophrenia and BPD development. Positive Comment on Study
Galimberti, D., 2014 SNP: rs5848, rs2879096, rs4792938
Other variant: GRN_C/T
One SNP in this gene is significant in BD-I, but not BD-II. Regarding the influence of GRN variability on BD susceptibility, the predisposing genetic background differs between BD-I and BD-II, possibly implying that pathogenic mechanisms differ between the two subtypes of BD. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 12)

GO terms by PBA (count: 1)

GO terms by database search (count: 11)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 1)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 1)

Gene related interactors from protein-protein interactions data in HPRD (count: 12)

Related other genetic factors
Gene related SNPs (count: 7)

Literature-origin SNPs (count: 5)

LD-proxies (count: 2)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Gene related regions (count: 5)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 0)

Gene relationship with MDD

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Region: chr17:44345086..44353102 View in gBrowse
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