Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	IFT88
Previous Symbol	TTC10
Symbol Alias	hTg737, Tg737, D13S1056E, MGC26259
Approved Name	intraflagellar transport 88
Previous Name	tetratricopeptide repeat domain 10, "intraflagellar transport 88 homolog (Chlamydomonas)"
Name Alias	polaris homolog
Location	13q12.1
Position	chr13:20567069-20691437, 1
External Links	HGNC: 20606 Entrez Gene: 8100 Ensembl: ENSG00000032742 UCSC: uc001uni.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Huang, J.,2010	SNP: rs7326068	No significant association of this gene was observed in BD.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 52)

GO terms by PBA (count: 0)

GO terms by database search (count: 52)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0031514	motile cilium	cellular component	ISS	4
GO:0031122	cytoplasmic microtubule organization	biological process	IEA	1
GO:0036064	ciliary basal body	cellular component	ISS	8
GO:0009952	anterior/posterior pattern specification	biological process	IEA	6
GO:0060271	cilium morphogenesis	biological process	ISS	2
GO:0001822	kidney development	biological process	IEA	13
GO:0060122	inner ear receptor stereocilium organization	biological process	IEA	2
GO:0007288	sperm axoneme assembly	biological process	IEA	1
GO:0034405	response to fluid shear stress	biological process	IEA	6
GO:0055007	cardiac muscle cell differentiation	biological process	IEA	2
GO:0042487	regulation of odontogenesis of dentin-containing tooth	biological process	IEA	1
GO:0060914	heart formation	biological process	IEA	1
GO:0030992	intraciliary transport particle B	cellular component	ISS	2
GO:2000785	regulation of autophagic vacuole assembly	biological process	ISS	1
GO:0031512	motile primary cilium	cellular component	IEA	2
GO:0060426	lung vasculature development	biological process	IEA	3
GO:0097541	axonemal basal plate	cellular component	IEA	1
GO:0045177	apical part of cell	cellular component	IEA	13
GO:0042733	embryonic digit morphogenesis	biological process	IEA	6
GO:0031016	pancreas development	biological process	IEA	2
GO:0090102	cochlea development	biological process	IEA	7
GO:0007219	Notch signaling pathway	biological process	IEA	14
GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway	biological process	IEA	2
GO:0008544	epidermis development	biological process	IEA	7
GO:0045598	regulation of fat cell differentiation	biological process	IEA	4
GO:0007290	spermatid nucleus elongation	biological process	IEA	1
GO:0060411	cardiac septum morphogenesis	biological process	IEA	1
GO:0019894	kinesin binding	molecular function	IEA	3
GO:0060091	kinocilium	cellular component	IEA	1
GO:0005814	centriole	cellular component	ISS	6
GO:0021537	telencephalon development	biological process	IEA	5
GO:0007368	determination of left/right symmetry	biological process	IEA	3
GO:0008104	protein localization	biological process	IEA	5
GO:0005929	cilium	cellular component	IDA[24421332]; ISS	10
GO:0036334	epidermal stem cell homeostasis	biological process	IEA	1
GO:0002080	acrosomal membrane	cellular component	IEA	1
GO:0001654	eye development	biological process	IEA	2
GO:0097546	ciliary base	cellular component	IEA	6
GO:0097542	ciliary tip	cellular component	TAS	5
GO:0032391	photoreceptor connecting cilium	cellular component	IEA	3
GO:0021513	spinal cord dorsal/ventral patterning	biological process	IEA	2
GO:1902017	regulation of cilium assembly	biological process	ISS	2
GO:0001889	liver development	biological process	IEA	14
GO:0008589	regulation of smoothened signaling pathway	biological process	IEA	7
GO:0070613	regulation of protein processing	biological process	IEA	3
GO:0006996	organelle organization	biological process	TAS	23
GO:0003382	epithelial cell morphogenesis	biological process	IEA	2
GO:0060021	palate development	biological process	IEA	6
GO:0072372	primary cilium	cellular component	TAS	5
GO:0050680	negative regulation of epithelial cell proliferation	biological process	IEA	4
GO:0048853	forebrain morphogenesis	biological process	IEA	2
GO:0007224	smoothened signaling pathway	biological process	IEA	5

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
IFT88	RPGR	NO	in vivo	16043481
IFT88	BAT2	NO	yeast 2-hybrid	14667819

Related other genetic factors

Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs7326068	chr13:20635373 - 20635373(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant	1(0/1/0)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
13p11.1-13q13	chr13:16500000-39500000	1 (0/0/1)
13q12-14	chr13:18900000-54700000	1 (0/1/0)
13q12	chr13:18900000-31600000	2 (0/1/1)
Chr 13	chr13:0-114364328	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Description	Result Category
20713499	No significant association of this gene was observed in SZ.	Negative

Overlap with SZ from candidate gene intersection analysis (count: 0)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Description	Category in MDD
20713499	Suggestive association was found with MDD.	Trend

Overlap with MDD from candidate gene intersection analysis (count: 0)

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Region: chr13:20567069..20691437 View in gBrowse