BDgene

SNP Report

Basic Info
Name rs6311 dbSNP Ensembl
Location chr13:46897343 - 46897343(1)
Variant Alleles C/T
Ancestral Allele C
Minor Allele T
Minor Allele Frequence 0.44349
Functional Annotation upstream_gene_variant.
Consequence to Transcript upstream_gene_variant(ENST00000378688, ENST00000542664, ENST00000543956, ENST00000612998)
No. of Studies 1 (Positive: 0; Negative: 1; Trend: 0)
Source Literature
Overlap with SZ? YES
Overlap with MDD? YES

SNP related studies (count: 1)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Gu, L.,2013 A/G Meta analysis: Allele model:Asian,OR = 0.93,95%CI = 0.73–1...... Meta analysis: Allele model:Asian,OR = 0.93,95%CI = 0.73–1.18; Caucasian,OR = 1.21,95%CI = 0.86–1.71; Total,OR = 1.01,95%CI = 0.83–1.22.Dominant model:Asian,OR = 0.98,95%CI = 0.80–1.21; Caucasian,OR = 1.11,95%CI = 0.82–1.49; Total,OR = 1.02,95%CI = 0.86–1.21.Recessive model:Asian,OR = 0.84,95%CI = 0.54–1.31; Caucasian,OR = 1.46,95%CI = 0.90–2.35; Total,OR = 0.99,95%CI = 0.69–1.42.Codominant model1:Asian,OR = 0.83,95%CI = 0.54–1.29; Caucasian,OR = 1.4,95%CI = 0.96–2.04; Total,OR = 0.98,95%CI = 0.69–1.39.Codominant model2:Asian,OR = 1.04,95%CI = 0.83–1.29; Caucasian,OR = 0.99,95%CI = 0.72–1.37; Total,OR = 1.02,95%CI = 0.86–1.23 More... We failed to observe a significant association between HTR2A...... We failed to observe a significant association between HTR2A 21438A/G polymorphism and BD with any genetic model, and there were no statistically significant differences between Caucasians and Asians. More... Negative

SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 13q14-q21 22(7/15/0)

SNPs in LD with rs6311 (count: 0) View in gBrowse (chr13:46897343..46897343 )

Overlap with SZ from cross-disorder studies (count: 1)
Reference Statistical Result Description Result Category
Gu, L.,2013 Meta analysis: Allele model:Asian,OR = 0.9,95%CI = 0.80–1.01; Caucasian,OR = 1.12,95%CI = 1.05–1.20; Total,OR = 1.06,95%CI = 1.00–1.12.Dominant model:Asian,OR = 0.91,95%CI = 0.76–1.08; Caucasian,OR = 1.14,95%CI = 1.03–1.27; Total,OR = 1.07,95%CI = 0.98–1.18.Recessive model:Asian,OR = 0.83,95%CI = 0.68–1.01; Caucasian,OR = 1.2,95%CI = 1.06–1.37; Total,OR = 1.08,95%CI = 0.97–1.20.Codominant model1:Asian,OR = 0.84,95%CI = 0.68–1.04; Caucasian,OR = 1.16,95%CI = 1.01–1.32; Total,OR = 1.06,95%CI = 0.94–1.19.Codominant model2:Asian,OR = 0.96,95%CI = 0.79–1.15; Caucasian,OR = 1.1,95%CI = 0.99–1.23; Total,OR = 1.06,95%CI = 0.97–1.17. Our results showed that the -1438A/G polymorphism was a risk factor for SZ, especially in Caucasians. Positive

Overlap with MDD from cross-disorder studies (count: 1)
Reference Statistical Result Description Result Category
Gu, L.,2013 Meta analysis: Allele model:Asian,OR = 0.86,95%CI = 0.67–1.09; Caucasian,OR = 1.13,95%CI = 0.80–1.59; Total,OR = 0.91,95%CI = 0.74–1.12.Dominant model:Asian,OR = 0.88,95%CI = 0.61–1.27; Caucasian,OR = 1.18,95%CI = 0.73–1.90; Total,OR = 0.96,95%CI = 0.73–1.25.Recessive model:Asian,OR = 0.84,95%CI = 0.62–1.14; Caucasian,OR = 1.14,95%CI = 0.56–2.31; Total,OR = 0.87,95%CI = 0.69–1.11.Codominant model:Asian,OR = 0.74,95%CI = 0.49–1.12; Caucasian,OR = 1.06,95%CI = 0.51–2.23; Total,OR = 0.79,95%CI = 0.56–1.11.Codominant model:Asian,OR = 0.97,95%CI = 0.75–1.25; Caucasian,OR = 1.17,95%CI = 0.71–1.92; Total,OR = 1.01,95%CI = 0.80–1.26 The results indicated that the HTR2A 21438A/G polymorphism was not associated with MDD in Caucasians in all genetic models. Negative

Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback Acknowledgements
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Last update: March 31, 2016