SNP Report

Basic Info

Name	rs2076137 dbSNP Ensembl
Location	chr22:50077337 - 50077337(1)
Variant Alleles	C/T
Ancestral Allele	C
Minor Allele	T
Minor Allele Frequence	0.152556
Functional Annotation	intron_variant; upstream_gene_variant.
Consequence to Transcript	intron_variant(ENST00000311597, ENST00000395876, ENST00000442311); upstream_gene_variant(ENST00000470008, ENST00000483836)
No. of Studies	2 (Positive: 0; Negative: 2; Trend: 0)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	NO

SNP related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Verma, R.,2005(b)	G/A		Case-control association: for BPAD, Fisher exact test, allel...... Case-control association: for BPAD, Fisher exact test, allele P-value > 0.05; chi-square test, genotype P-value(additive)>0.05, P-value(dominant)>0.05, P-value(recessive)>0.05 ; Family-Based Association: for BPAD, TDT, P-value > 0.05 More...	No significant association was observed. No significant association was observed.	Negative
Selch, S., 2007	C/T		chi-square tests, P-value > 0.05 chi-square tests, P-value > 0.05	No association with the combined patient sample or BPD was f...... No association with the combined patient sample or BPD was found. More...	Negative

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
MLC1	megalencephalic leukoencephalopathy with subcortical cysts 1	22q13.33	5(1/4/0)

SNPs in LD with rs2076137 (count: 0) View in gBrowse (chr22:50077337..50077337 )

Overlap with SZ from cross-disorder studies (count: 2)

Reference	Statistical Result	Description	Result Category
Selch, S., 2007	chi-square tests, P-value > 0.05	No association with the combined patient sample, SCZ or type A or type B schizophrenia was found.	Negative
Verma, R.,2005(b)	Case-control association:for SCZ, Fisher exact test, allele P-value = 0.03; chi-square test, genotype P-value(additive)=0.02, P-value(dominant)=0.01, P-value(recessive)>0.05 ;Family-Based Association:for SCZ, TDT, P-value > 0.05	Significant association was observed in case-control association analysis.	Positive

Overlap with MDD from cross-disorder studies (count: 0)