Meta-analysis Report

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Basic Info

Reference	Tan J., 2014 PMID: 24962835
Citation	Tan, J., et al. (2014). "Association of the T102C polymorphism in the HTR2A gene with major depressive disorder, bipolar disorder, and schizophrenia." Am J Med Genet B Neuropsychiatr Genet.
Disease Type	Bipolar Disorder & Schizophrenia & Major Depressive Disorder
Study Type	Candidate-gene association study

Detail Info

Samples	17,178 cases and 20,855 control subjects
Statistic Method	Pearson's chi-squared test (cut-off point: P<0.05) was used to evaluate the Hardy-Weinberg equilibrium (HWE) of the control groupprior to statistical analysis. ORs and 95% confidence intervals(CI) were used to measure the strength of separate associations between the HTR2A T102C polymorphism and the risk of MDD, BPD and SCZ. The heterogeneity across all eligible studies was evaluated using Cochranâ€™s chi-square-based Q-statistic and I². All statistical analyses were conducted using Stata 11.1.
Basic Result	No significant association was found in the overall analysis of MDD, BPD and SCZ with a sample size of 17,178 cases and 20,855 control subjects. In a further analysis by ethnicity, the OR and 95% CIs indicated the T102C polymorphism was not associated with MDD, BPD, or SCZ in Caucasian, Asian or Chinese populations.No publication bias was observed in the meta-analysis, and the cumulative analyses indicated the robust stability of the results.

Genetic factors reported by this study for BD

SNPs reported by this study for BD (count: 1)

SNP	Related Gene(s)	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
rs6313	HTR2A	T/C		Overall: T vs. C (Allele frequency): OR=0.987, 95%CI=0.908-1.073, P-value=0.761; TTâ€‰+â€‰TC vs. CC (Dominant): OR=0.972, 95%CI=0.838-1.128, P-value=0.708; TT vs. TCâ€‰+â€‰CC (Recessive): OR=1.064, 95%CI=0.913-1.240, P-value=0.428; TT vs. TC (Codominant1): OR=1.073, 95%CI=0.912-1.263, P-value=0.394; TC vs. CC (Codominant2): OR=0.957, 95%CI=0.818-1.120, P-value=0.581; TT vs. CC (Homozygote): OR=1.004, 95%CI=0.831-1.214, P-value=0.964. Caucasian: T vs. C (Allele frequency): OR=0.904, 95%CI=0.806-1.014, P-value=0.086; TTâ€‰+â€‰TC vs. CC (Dominant): OR=0.920, 95%CI=0.759-1.116, P-value=0.399; TT vs. TCâ€‰+â€‰CC (Recessive): OR=0.915, 95%CI=0.728-1.150, P-value=0.446; TT vs. TC (Codominant1): OR=0.936, 95%CI=0.736-1.192, P-value=0.592; TC vs. CC (Codominant2): OR=0.942, 95%CI=0.768-1.156, P-value=0.568; TT vs. CC (Homozygote): OR=0.869, 95%CI=0.668-1.130, P-value=0.294. Asian: T vs. C (Allele frequency): OR=1.089, 95%CI=0.964-1.230, P-value=0.169; TTâ€‰+â€‰TC vs. CC (Dominant): OR=1.052, 95%CI=0.834-1.326, P-value=0.669; TT vs. TCâ€‰+â€‰CC (Recessive): OR=1.205, 95%CI=0.979-1.482, P-value=0.078; TT vs. TC (Codominant1): OR=1.203, 95%CI=0.965-1.500, P-value=0.1; TC vs. CC (Codominant2): OR=0.978, 95%CI=0.764-1.252, P-value=0.861; TT vs. CC (Homozygote): OR=1.175, 95%CI=0.894-1.545, P-value=0.248. Chinese: T vs. C (Allele frequency): OR=1.037, 95%CI=0.799-1.346, P-value=0.784; TTâ€‰+â€‰TC vs. CC (Dominant): OR=0.933, 95%CI=0.570-1.526, P-value=0.782; TT vs. TCâ€‰+â€‰CC (Recessive): OR=1.128, 95%CI=0.771-1.651, P-value=0.535; TT vs. TC (Codominant1): OR=1.166, 95%CI=0.780-1.743, P-value=0.454; TC vs. CC (Codominant2): OR=0.867, 95%CI=0.515-1.460, P-value=0.592; TT vs. CC (Homozygote): OR=1.030, 95%CI=0.595-1.783, P-value=0.915	The results of our study indicate that theT102C polymorphism...... The results of our study indicate that theT102C polymorphism is not associates with increased susceptibility to BPD. More...	Negative

Genes reported by this study for BD (count: 1)

Gene	Statistical Values/Author Comments	Result Category
HTR2A	The T102C polymorphism in HTR2A showed no association with BD. The T102C polymorphism in HTR2A showed no association with BD.	Negative

Genetic factors reported by this study for SZ and/or MDD

SNPs reported by this study for SZ/MDD

Disease	SNP	Related Gene(s)	Statistical Values	Description	Result Category
SZ	rs6313	HTR2A	Overall: T vs. C (Allele frequency): OR=0.970, 95%CI=0.914-1.030, P-value=0.316; TTâ€‰+â€‰TC vs. CC (Dominant): OR=0.970, 95%CI=0.888-1.059, P-value=0.495; TT vs. TCâ€‰+â€‰CC (Recessive): OR=0.965, 95%CI=0.885-1.053, P-value=0.428; TT vs. TC (Codominant1): OR=0.982, 95%CI=0.921-1.047, P-value=0.578; TC vs. CC (Codominant2): OR=1.010, 95%CI=0.949-1.074, P-value=0.761; TT vs. CC (Homozygote): OR=0.948, 95%CI=0.838-1.073, P-value=0.397. Caucasian: T vs. C (Allele frequency): OR=0.994, 95%CI=0.903-1.093, P-value=0.894; TTâ€‰+â€‰TC vs. CC (Dominant): OR=0.989, 95%CI=0.887-1.102, P-value=0.84; TT vs. TCâ€‰+â€‰CC (Recessive): OR=0.989, 95%CI=0.838-1.167, P-value=0.895; TT vs. TC (Codominant1): OR=1.011, 95%CI=0.919-1.112, P-value=0.824; TC vs. CC (Codominant2): OR=1.018, 95%CI=0.940-1.102, P-value=0.664; TT vs. CC (Homozygote): OR=0.968, 95%CI=0.796-1.178, P-value=0.747. Asian: T vs. C (Allele frequency): OR=0.952, 95%CI=0.879-1.032, P-value=0.232; TTâ€‰+â€‰TC vs. CC (Dominant): OR=0.956, 95%CI=0.822-1.113, P-value=0.564; TT vs. TCâ€‰+â€‰CC (Recessive): OR=0.949, 95%CI=0.867-1.040, P-value=0.265; TT vs. TC (Codominant1): OR=0.951, 95%CI=0.870-1.038, P-value=0.261; TC vs. CC (Codominant2): OR=1.016, 95%CI=0.917-1.126, P-value=0.761; TT vs. CC (Homozygote): OR=0.933, 95%CI=0.786-1.106, P-value=0.423. Other/Mixed: T vs. C (Allele frequency): OR=0.929, 95%CI=0.742-1.164, P-value=0.523; TTâ€‰+â€‰TC vs. CC (Dominant): OR=0.834, 95%CI=0.521-1.333, P-value=0.447; TT vs. TCâ€‰+â€‰CC (Recessive): OR=1.034, 95%CI=0.719-1.486, P-value=0.856; TT vs. TC (Codominant1): OR=1.142, 95%CI=0.772-1.69, P-value=0.505; TC vs. CC (Codominant2): OR=0.769, 95%CI=0.525-1.128, P-value=0.179; TT vs. CC (Homozygote): OR=0.882, 95%CI=0.572-1.360, P-value=0.57. Chinese: T vs. C (Allele frequency): OR=0.990, 95%CI=0.925-1.059, P-value=0.77; TTâ€‰+â€‰TC vs. CC (Dominant): OR=1.017, 95%CI=0.899-1.150, P-value=0.793; TT vs. TCâ€‰+â€‰CC (Recessive): OR=0.967, 95%CI=0.875-1.069, P-value=0.516; TT vs. TC (Codominant1): OR=0.957, 95%CI=0.861-1.064, P-value=0.419; TC vs. CC (Codominant2): OR=1.032, 95%CI=0.905-1.176, P-value=0.64; TT vs. CC (Homozygote): OR=1.004, 95%CI=0.872-1.154, P-value=0.961	The results of our study indicate that theT102C polymorphism is not associates with increased susceptibility to SCZ.	Negative
MDD	rs6313	HTR2A	Overall: T vs. C (Allele frequency): OR=1.006, 95%CI=0.914-1.107, P-value=0.908; TTâ€‰+â€‰TC vs. CC (Dominant): OR=0.999, 95%CI=0.845-1.181, P-value=0.994; TT vs. TCâ€‰+â€‰CC (Recessive): OR=1.033, 95%CI=0.919-1.161, P-value=0.592; TT vs. TC (Codominant1): OR=1.022, 95%CI=0.903-1.158, P-value=0.73; TC vs. CC (Codominant2): OR=1.012, 95%CI=0.891-1.148, P-value=0.856; TT vs. CC (Homozygote): OR=0.993, 95%CI=0.807-1.222, P-value=0.949. Caucasian: T vs. C (Allele frequency): OR=1.055, 95%CI=0.894-1.246, P-value=0.528; TTâ€‰+â€‰TC vs. CC (Dominant): OR=1.085, 95%CI=0.806-1.461, P-value=0.689; TT vs. TCâ€‰+â€‰CC (Recessive): OR=1.068, 95%CI=0.852-1.339, P-value=0.568; TT vs. TC (Codominant1): OR=1.028, 95%CI=0.809-1.306, P-value=0.824; TC vs. CC (Codominant2): OR=1.085, 95%CI=0.878-1.342, P-value=0.449; TT vs. CC (Homozygote): OR=1.092, 95%CI=0.781-1.527, P-value=0.607. Asian: T vs. C (Allele frequency): OR=0.980, 95%CI=0.868-1.106, P-value=0.743; TTâ€‰+â€‰TC vs. CC (Dominant): OR=0.950, 95%CI=0.772-1.169, P-value=0.629; TT vs. TCâ€‰+â€‰CC (Recessive): OR=1.020, 95%CI=0.890-1.169, P-value=0.778; TT vs. TC (Codominant1): OR=1.020, 95%CI=0.882-1.180, P-value=0.788; TC vs. CC (Codominant2): OR=0.973, 95%CI=0.831-1.139, P-value=0.737; TT vs. CC (Homozygote): OR=0.936, 95%CI=0.713-1.229, P-value=0.635. Chinese: T vs. C (Allele frequency): OR=1.008, 95%CI=0.864-1.177, P-value=0.917; TTâ€‰+â€‰TC vs. CC (Dominant): OR=1.034, 95%CI=0.850-1.259, P-value=0.736; TT vs. TCâ€‰+â€‰CC (Recessive): OR=1.042, 95%CI=0.877-1.238, P-value=0.637; TT vs. TC (Codominant1): OR=1.021, 95%CI=0.851-1.225, P-value=0.823; TC vs. CC (Codominant2): OR=1.026, 95%CI=0.833-1.264, P-value=0.81; TT vs. CC (Homozygote): OR=0.977, 95%CI=0.664-1.436, P-value=0.905	The results of our study indicate that theT102C polymorphism is not associates with increased susceptibility to MDD.	Negative

Genes reported by this study for SZ/MDD

Disease	Gene	Description	Result Category
SZ	HTR2A	The T102C polymorphism in HTR2A showed no association with SZ.	Negative
MDD	HTR2A	The T102C polymorphism in HTR2A showed no association with MDD.	Negative