SNP Report

Basic Info

Name	rs2859387 dbSNP Ensembl
Location	chr1:7827188 - 7827188(1)
Variant Alleles	G/A/C
Ancestral Allele	G
Minor Allele	G
Minor Allele Frequence	0.483227
Functional Annotation	non_coding_transcript_exon_variant; non_coding_transcript_variant; synonymous_variant.
Consequence to Transcript	non_coding_transcript_exon_variant(ENST00000451646); non_coding_transcript_variant(ENST00000451646); synonymous_variant(ENST00000361923, ENST00000377532, ENST00000613533, ENST00000614998)
No. of Studies	1 (Positive: 1; Negative: 0; Trend: 0)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	NO

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Mansour, H. A., 2006	A/G		TDT P-value = 0.803 in the samples combined, Pittsburgh Tren...... TDT P-value = 0.803 in the samples combined, Pittsburgh Trends test=0.039 for BDI More...	For the contrasts of genotype distributions for individuals ...... For the contrasts of genotype distributions for individuals from the Pittsburgh sample diagnosed with BD1 vs. the population in general, significant differences were detected. More...	Positive

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
PER3	period circadian clock 3	1p36.23	7(3/4/0)

SNPs in LD with rs2859387 (count: 0) View in gBrowse (chr1:7827188..7827188 )

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Mansour, H. A., 2006	TDT P-value = 0.02, X²=5.36, df=1, Trends test=0.168 for Pittsburgh SZ/SZA	When we analyzed transmission bias in the SZ/SZA samples, we observed significant transmission distortion at this loci.	Positive

Overlap with MDD from cross-disorder studies (count: 0)