Gene Report

Basic Info
Approved Symbol MAD1L1
Symbol Alias HsMAD1, TXBP181, MAD1, PIG9, TP53I9
Approved Name MAD1 mitotic arrest deficient-like 1 (yeast)
Previous Name MAD1 (mitotic arrest deficient, yeast, homolog)-like 1
Location 7p22
Position chr7:1815793-2233243, -1
External Links HGNC: 6762
Entrez Gene: 8379
Ensembl: ENSG00000002822
UCSC: uc003slg.1
No. of Studies 5 (Positive: 1; Negative: 2; trend: 2)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 5)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Cichon, S.,2011 SNP: rs10278591, rs11764590 In summary, the present study has identified a potential BD susceptibility factor, MAD1L1. Trend Comment on Study
Green, E. K.,2012 SNP: rs4332037 BD ImmunoChip:P-value = 0.739,OR = 1.022;ImmunoChip, PGC-BD combined data:P-balue = 0.0000429,OR = 0.914 No significant association was observed. Negative Comment on Study
Sklar, P.,2011 SNP: rs4332037 Suggestive association was found. Trend Comment on Study
Ruderfer, D. M., 2013 SNP: rs10275045 The SNP within or near this gene did not achieve genome-wide significance. Negative Comment on Study
Kondo, K.,2013 Significant association was observed. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 17)

GO terms by PBA (count: 1)

GO terms by database search (count: 16)

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 1)

KEGG pathways by database search (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 18)

Related other genetic factors
Gene related SNPs (count: 29)

Literature-origin SNPs (count: 9)

LD-proxies (count: 20)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 2)

Overlap with SZ from candidate gene intersection analysis (count: 0)

Gene relationship with MDD

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Region: chr7:1815793..2233243 View in gBrowse
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