BDgene

Gene Report

Basic Info
Approved Symbol BRD1
Symbol Alias BRL, BRPF2
Approved Name bromodomain containing 1
Previous Name bromodomain-containing 1
Name Alias BR140-like
Location 22q13.33
Position chr22:49773283-49827512, -1
External Links HGNC: 1102
Entrez Gene: 23774
Ensembl: ENSG00000100425
UCSC: uc003biv.3
No. of Studies 2 (Positive: 2; Negative: 0; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Severinsen, J. E., 2006 (b) SNP: rs138855, rs138880, rs138881, rs2239848, rs4468
Haplotype: D22S922 - D22S1169 - rs4468(2-3-C), rs138855 - rs138880(G-C), rs138855 - rs138880 - rs138881(G-C-A), rs138855 - rs138880 - rs138881(G-C-G), rs138855 - rs2239848 - rs138880(G-G-C), rs138855 - rs2239848 - rs138880 - rs138881(G-G-C-A), rs138855 - rs4468(), rs138855 - rs4468 - D22S1169(), rs138855 - rs4468 - D22S1169 - D22S922(), rs138880 - rs2239848(), rs138880 - rs2239848 - rs138855(), rs138880 - rs2239848 - rs138855 - rs4468(), rs138881 - rs138880(), rs138881 - rs138880 - rs2239848(), rs138881 - rs138880 - rs2239848 - rs138855(), rs2239848 - rs138855(), rs2239848 - rs138855 - rs4468(), rs2239848 - rs138855 - rs4468 - D22S1169(), rs4468 - D22S1169(), rs4468 - D22S1169 - D22S922(), rs4468 - D22S1169 - D22S922 - rs132234(), rs137931 - rs6010260 - rs138881(), rs137931 - rs6010260 - rs138881 - rs138880(), rs137932 - rs137931 - rs6010260 - rs138881(), rs6010260 - rs138881(), rs6010260 - rs138881 - rs138880(), rs6010260 - rs138881 - rs138880 - rs2239848()
The results implicate BRD1 with SZ and BPD susceptibility and provide evidence that suggests a role for BRD1 in neurodevelopment. Positive Comment on Study
Nyegaard, M., 2010 SNP: rs138820, rs138830, rs138841, rs138851, rs138855, rs138863, rs138864, rs138880, rs138887, rs139811, rs2239848, rs3788731, rs4468, rs5769750
Haplotype: rs138820 - rs4468(CC), rs138820 - rs4468(TT), rs138820 - rs4468 - rs138841(CCA), rs138820 - rs4468 - rs138841(TTC), rs138841 - rs138855(CG), rs138841 - rs138855 - rs138864(CGG), rs138864 - rs2239848(GG), rs4468 rs138841(CA), rs4468 rs138841(TC), rs4468 - rs138841 - rs138855(TCG)
The associations reported add further support for the implication of BRD1 with SZ and BPD susceptibility. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 6)

GO terms by PBA (count: 1)

GO terms by database search (count: 5)


Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Related other genetic factors
Gene related SNPs (count: 34)

Literature-origin SNPs (count: 15)

LD-proxies (count: 19)


Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 2)

Overlap with SZ from candidate gene intersection analysis (count: 3)


Gene relationship with MDD

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Region: chr22:49773283..49827512 View in gBrowse
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