SNP Report

Basic Info

Name	rs4332037 dbSNP Ensembl
Location	chr7:1911173 - 1911173(1)
Variant Alleles	C/T
Ancestral Allele	C
Minor Allele	T
Minor Allele Frequence	0.180112
Functional Annotation	intron_variant.
Consequence to Transcript	intron_variant(ENST00000265854, ENST00000399654, ENST00000402746, ENST00000406869, ENST00000437877, ENST00000450235)
No. of Studies	3 (Positive: 1; Negative: 1; Trend: 1)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	NO

SNP related studies (count: 3)

Reference	Allele Change	Statistical Values	Author Comments	Result Category
Andreassen OA, 2013		Conditional FDR; BD loci given SCZ: P-value=0.0000397, FDR=0...... Conditional FDR; BD loci given SCZ: P-value=0.0000397, FDR=0.22281, FDR=0.02918 for BD and SCZ More...	This SNP is with conditional FDR<0.05 in schizophrenia given...... This SNP is with conditional FDR<0.05 in schizophrenia given association with bipolar disorder after 'pruning'. More...	Positive
Green, E. K.,2012	C/T	BD ImmunoChip:P-value = 0.739,OR = 1.022;ImmunoChip, PGC-BD ...... BD ImmunoChip:P-value = 0.739,OR = 1.022;ImmunoChip, PGC-BD combined data:P-balue = 0.0000429,OR = 0.914 More...	No significant association was observed. No significant association was observed.	Negative
Sklar, P.,2011	C/T	Primary GWAS P-value(GC)=0.0000178, OR=0.87; replication P-v...... Primary GWAS P-value(GC)=0.0000178, OR=0.87; replication P-value(1-sided)=0.03, OR=0.93; Combined GWAS and replication P-value(GC)=0.00000725, OR=0.9 More...	Suggestive association was found. Suggestive association was found.	Trend

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
MAD1L1	MAD1 mitotic arrest deficient-like 1 (yeast)	7p22	5(1/2/2)

SNPs in LD with rs4332037 (count: 5) View in gBrowse (chr7:1894495..1922527 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Functional Annotation	r²[population]
rs10267593	downstream_gene_variant; intron_variant	1.0[CEU]; 0.865[TSI]
rs6461009	intron_variant	1.0[CEU]
rs6951956	downstream_gene_variant; intron_variant	0.817[TSI]
rs10268609	intron_variant	0.93[TSI]
rs6947019	intron_variant	1.0[CEU]

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Andreassen OA, 2013	Conditional FDR; BD loci given SCZ: FDR=0.02918 for BD and SCZ	This SNP is with conditional FDR<0.05 in schizophrenia given association with bipolar disorder after 'pruning'.	Positive

Overlap with MDD from cross-disorder studies (count: 0)