BDgene

SNP Report

Basic Info
Name rs1573745 dbSNP Ensembl
Location chr22:40844831 - 40844831(1)
Variant Alleles G/A
Ancestral Allele G
Minor Allele A
Minor Allele Frequence 0.0838658
Functional Annotation intron_variant; NMD_transcript_variant; splice_region_variant.
Consequence to Transcript intron_variant(ENST00000216218, ENST00000411695, ENST00000413424, ENST00000455824, ENST00000620312); NMD_transcript_variant(ENST00000413424, ENST00000455824); splice_region_variant(ENST00000216218, ENST00000411695, ENST00000413424, ENST00000455824, ENST00000620312)
No. of Studies 1 (Positive: 0; Negative: 1; Trend: 0)
Source Literature
Overlap with SZ? YES
Overlap with MDD? NO

SNP related studies (count: 1)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Severinsen, J. E., 2006 (a) G/A Empirical overall P-value = 0.1588 for BPD in the Case-Contr...... Empirical overall P-value = 0.1588 for BPD in the Case-Control Sample From Scotland; Empirical overall P-value = 0.7989 for BPD and SZ in the Case-Control Sample From Scotland More... Negative

SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 22q13.2 1(1/0/0)

SNPs in LD with rs1573745 (count: 27) View in gBrowse (chr22:40819179..40985247 )
The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 27)


Overlap with SZ from cross-disorder studies (count: 1)
Reference Statistical Result Description Result Category
Severinsen, J. E., 2006 (a) Empirical overall P-value = 0.2879 for SZ in the Case-Control Sample From Scotland; Empirical overall P-value = 0.7989 for BPD and SZ in the Case-Control Sample From Scotland Negative

Overlap with MDD from cross-disorder studies (count: 0)