Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

ADD to My Gene Set

Comment on Gene

View All Comments on Gene

Basic Info

Approved Symbol	ZBED4
Symbol Alias	KIAA0637
Approved Name	zinc finger, BED-type containing 4
Location	22q13.33
Position	chr22:49853842-49890078, 1
External Links	HGNC: 20721 Entrez Gene: 9889 Ensembl: ENSG00000100426 UCSC: uc003bix.2
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Nyegaard, M., 2010	SNP: rs3788731, rs4624, rs5769750, rs5770755, rs6009917, rs910799	Due to highLD in the region harboring BRD1, we included SNPs located within the ZBED4 gene in this replication analysis. Analysis of genotyped SNPs as well as imputed genotypes showed the strongest association with markers in BRD1. However, due to the high LD we cannot completely rule out ZBED4 as a positional candidate gene for SZ and BPD.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 7)

GO terms by PBA (count: 2)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0003677	DNA binding	molecular function	IEA	83
GO:0005634	nucleus	cellular component	IDA[19369242]	283

GO terms by database search (count: 5)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0046872	metal ion binding	molecular function	IEA	115
GO:0005737	cytoplasm	cellular component	IDA[19369242]	322
GO:0005515	protein binding	molecular function	IPI[25416956]	563
GO:0005654	nucleoplasm	cellular component	IDA	163
GO:0046983	protein dimerization activity	molecular function	IEA	19

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 47)

Literature-origin SNPs (count: 6)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs3788731	chr22:49851129 - 49851129(1)	downstream_gene_variant; upstream_gene_variant	1(1/0/0)
rs6009917	chr22:49887696 - 49887696(1)	3_prime_UTR_variant	1(0/1/0)
rs5770755	chr22:49886488 - 49886488(1)	synonymous_variant	1(0/1/0)
rs910799	chr22:49884920 - 49884920(1)	missense_variant	1(0/1/0)
rs4624	chr22:49888269 - 49888269(1)	3_prime_UTR_variant	1(0/1/0)
rs5769750	chr22:49843947 - 49843947(1)	upstream_gene_variant	1(1/0/0)

LD-proxies (count: 41)

rs_ID	Location	Functional Annotation
rs761878	chr22:49856029 - 49856029(1)	downstream_gene_variant; intron_variant
rs5770720	chr22:49859453 - 49859453(1)	intron_variant
rs5770722	chr22:49859572 - 49859572(1)	intron_variant
rs4824111	chr22:49890657 - 49890657(1)	downstream_gene_variant
rs738711	chr22:49888955 - 49888955(1)	3_prime_UTR_variant
rs2236139	chr22:49883047 - 49883047(1)	intron_variant
rs4824110	chr22:49877983 - 49877983(1)	intron_variant
rs2092982	chr22:49888556 - 49888556(1)	3_prime_UTR_variant
rs5770725	chr22:49862661 - 49862661(1)	intron_variant
rs738710	chr22:49869354 - 49869354(1)	intron_variant
rs5770741	chr22:49876567 - 49876567(1)	intron_variant
rs910800	chr22:49884994 - 49884994(1)	synonymous_variant
rs4824107	chr22:49877766 - 49877766(1)	intron_variant
rs5770731	chr22:49868783 - 49868783(1)	intron_variant
rs8140403	chr22:49866875 - 49866875(1)	intron_variant
rs932536	chr22:49866824 - 49866824(1)	intron_variant
rs13056374	chr22:49865266 - 49865266(1)	intron_variant
rs11705677	chr22:49865219 - 49865219(1)	intron_variant
rs11091000	chr22:49865150 - 49865150(1)	intron_variant
rs2180403	chr22:49864018 - 49864018(1)	intron_variant
rs5770724	chr22:49862224 - 49862224(1)	intron_variant
rs5770721	chr22:49859489 - 49859489(1)	intron_variant
rs733382	chr22:49859206 - 49859206(1)	intron_variant
rs1977169	chr22:49850099 - 49850099(1)	downstream_gene_variant; upstream_gene_variant
rs1569954	chr22:49850423 - 49850423(1)	downstream_gene_variant; upstream_gene_variant
rs1033665	chr22:49858479 - 49858479(1)	intron_variant
rs4574208	chr22:49863090 - 49863090(1)	intron_variant
rs11703411	chr22:49865103 - 49865103(1)	intron_variant
rs5769760	chr22:49866048 - 49866048(1)	intron_variant
rs910798	chr22:49884790 - 49884790(1)	synonymous_variant
rs5770728	chr22:49866336 - 49866336(1)	intron_variant
rs738712	chr22:49889338 - 49889338(1)	3_prime_UTR_variant
rs8139758	chr22:49867475 - 49867475(1)	intron_variant
rs1980565	chr22:49881677 - 49881677(1)	intron_variant
rs5769762	chr22:49870394 - 49870394(1)	intron_variant
rs910796	chr22:49884187 - 49884187(1)	synonymous_variant
rs5770739	chr22:49874366 - 49874366(1)	intron_variant
rs2092981	chr22:49878580 - 49878580(1)	intron_variant
rs5770742	chr22:49876661 - 49876661(1)	intron_variant
rs8184990	chr22:49879526 - 49879526(1)	intron_variant
rs4597652	chr22:49876922 - 49876922(1)	intron_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 22	chr22:0-50818468	2 (0/1/1)
22q12.3-q13.33	chr22:31800000-50818468	1 (1/0/0)
22q13	chr22:37200000-50818468	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Description	Result Category
19693800	Due to highLD in the region harboring BRD1, we included SNPs located within the ZBED4 gene in this replication analysis. Analysis of genotyped SNPs as well as imputed genotypes showed the strongest association with markers in BRD1. However, due to the high LD we cannot completely rule out ZBED4 as a positional candidate gene for SZ and BPD.	Positive

Overlap with SZ from candidate gene intersection analysis (count: 1)

Reference	ID in SZGene	Result Category
19693800	855	Positive

Gene relationship with MDD

View in gBrowse

Region: chr22:49853842..49890078 View in gBrowse