BDgene

SNP Report

Basic Info
Name rs133073 dbSNP Ensembl
Location chr22:40679691 - 40679691(1)
Variant Alleles C/T
Ancestral Allele C
Minor Allele C
Minor Allele Frequence 0.382388
Functional Annotation intron_variant; non_coding_transcript_variant; synonymous_variant; upstream_gene_variant.
Consequence to Transcript intron_variant(ENST00000498400); non_coding_transcript_variant(ENST00000498400); synonymous_variant(ENST00000249016, ENST00000381433); upstream_gene_variant(ENST00000465662)
No. of Studies 2 (Positive: 0; Negative: 2; Trend: 0)
Source Literature
Overlap with SZ? YES
Overlap with MDD? NO

SNP related studies (count: 2)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Severinsen, J. E., 2006 (a) T/C CLUMP T1 P-value = 0.4217, CLUMP T4 P-value = 0.4217 for BPD...... CLUMP T1 P-value = 0.4217, CLUMP T4 P-value = 0.4217 for BPD; CLUMP T1 P-value = 0.0546, CLUMP T4 P-value = 0.0546 for BPD and SZ in the Faeroese Sample; Empirical overall P-value = 0.347 for BPD in the Case-Control Sample From Scotland; Empirical overall P-value = 0.5632 for BPD and SZ in the Case-Control Sample From Scotland More... Negative
Yosifova, A.,2009 C/T Allelic association: P-value = 0.43 Allelic association: P-value = 0.43 No significant association was observed No significant association was observed Negative

SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
MCHR1 melanin-concentrating hormone receptor 1 22q13.3 2(1/1/0)

SNPs in LD with rs133073 (count: 4) View in gBrowse (chr22:40670883..40679691 )
The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 4)


Overlap with SZ from cross-disorder studies (count: 1)
Reference Statistical Result Description Result Category
Severinsen, J. E., 2006 (a) CLUMP T1 P-value = 0.0083, CLUMP T4 P-value = 0.0083 for SZ; CLUMP T1 P-value = 0.0546, CLUMP T4 P-value = 0.0546 for BPD and SZ in the Faeroese Sample; Empirical overall P-value = 0.8469 for SZ in the Case-Control Sample From Scotland; Empirical overall P-value = 0.5632 for BPD and SZ in the Case-Control Sample From Scotland The three GPR24 SNPs rs133068, rs133069, and rs133073 showed association with SZ yielding P-values of 0.008-0.02. Positive

Overlap with MDD from cross-disorder studies (count: 0)