BDgene

SNP Report

Basic Info
Name rs9804190 dbSNP Ensembl
Location chr10:60080073 - 60080073(1)
Variant Alleles C/T
Ancestral Allele T
Minor Allele T
Minor Allele Frequence 0.257788
Functional Annotation downstream_gene_variant; intron_variant; upstream_gene_variant.
Consequence to Transcript downstream_gene_variant(ENST00000508449, ENST00000622427); intron_variant(ENST00000280772, ENST00000355288, ENST00000373820, ENST00000373827, ENST00000503366, ENST00000511043, ENST00000610321, ENST00000616444); upstream_gene_variant(ENST00000365320)
No. of Studies 6 (Positive: 2; Negative: 4; Trend: 0)
Source Literature
Overlap with SZ? YES
Overlap with MDD? NO

SNP related studies (count: 6)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Lett, T. A.,2011 T/C T FBAT: P-value = 0.32 FBAT: P-value = 0.32 No significant association was observed in BD. No significant association was observed in BD. Negative
Green, E. K.,2012 C/T BD ImmunoChip:P-value = 0.682,OR = 0.977;ImmunoChip, PGC-BD ...... BD ImmunoChip:P-value = 0.682,OR = 0.977;ImmunoChip, PGC-BD combined data:P-balue = 0.000736,OR = 1.08 More... No significant association was observed. No significant association was observed. Negative
Schulze, T. G.,2009 C/T single marker case-control association: in German sample, P-...... single marker case-control association: in German sample, P-value(OR)=0.050 (1.24), in NIMH 1-4 sample, P-value(OR)=0.017 (1.38), in NIMH 5 sample, P-value(OR)=0.017 (1.38) More... Significant association was observed Significant association was observed Positive
Tesli, M.,2011 T/C SCOPE sample: MAF=0.21, Cochrane-Mantel-Haenszel test P-valu...... SCOPE sample: MAF=0.21, Cochrane-Mantel-Haenszel test P-value = 0.18, Bonferroni corrected P-value = 0.54, OR (95%CI)=0.9(0.78-1.05); Icelandic sample: MAF(affected)=0.19, MAF(unaffected)=0.22, allelic P-value = 0.05, Bonferroni corrected P-value = 0.15, OR (95%CI)=0.84(0.70-0.99) More... Significant association was found. Significant association was found. Positive
Sklar, P.,2011 C/T Primary GWAS P-value(GC)=0.0000306, OR=1.17; replication P-v...... Primary GWAS P-value(GC)=0.0000306, OR=1.17; replication P-value(1-sided)=0.0963, OR=1.04; Combined GWAS and replication P-value(GC)=0.00012, OR=1.1 More... No significant association was observed. No significant association was observed. Negative
Gella, A.,2011 C/T Genotype association: CC P-value = 0.237, CT P-value = 0.101...... Genotype association: CC P-value = 0.237, CT P-value = 0.101, TT P-value = 0.337 for BD. More... No significant association was observed. No significant association was observed. Negative

SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 10q21 17(13/3/1)

SNPs in LD with rs9804190 (count: 0) View in gBrowse (chr10:60080073..60080073 )

Overlap with SZ from cross-disorder studies (count: 2)
Reference Statistical Result Description Result Category
Gella, A.,2011 Genotype association:CC P-value = 0.949, CT P-value = 0.674, TT P-value = 0.284 for SZ. No significant association was observed. Negative
Tesli, M.,2011 SCOPE sample:MAF=0.21, Cochrane-Mantel-Haenszel test P-value = 0.88, Bonferroni corrected P-value = 1, OR (95%CI)=0.99(0.87-1.13);Icelandic sample:MAF(affected)=0.23, MAF(unaffected)=0.22, allelic P-value = 0.5, Bonferroni corrected P-value = 1, OR (95%CI)=1.05(0.92-1.20) No significant association was observed. Negative

Overlap with MDD from cross-disorder studies (count: 0)